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Therapy: Chemotherapy
Nutrition: Carbohydrates
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Total 234 results found since Jan 2013.
Serum basic fibroblast growth factor and interleukin-1 β predict the effect of first-line chemotherapy in patients with advanced gastric cancer
CONCLUSION: The FLOT regimen was effective in reducing the serum CEA, CA199, and TPS levels as well as in improving the 1-year survival rate of patients with good tolerability, making it worthy of clinical promotion and application.PMID:37731570 | PMC:PMC10507556 | DOI:10.12998/wjcc.v11.i26.6083
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Li Zheng Li-Hong Gan Ling Yao Bin Li Ya-Qin Huang Fu-Bao Zhang Meng-Qi Kuang Nian Fang Source Type: research
Improving prognosis and assessing adjuvant chemotherapy benefit in locally advanced rectal cancer with deep learning for MRI: a retrospective, multi-cohort study
CONCLUSION: The MuST model accurately and non-invasively predicted OS, DM, and LR. A specific and direct tool linking chemotherapy decisions and benefit quantification has also been provided.PMID:37660753 | DOI:10.1016/j.radonc.2023.109899
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 3, 2023 Category: Radiology Authors: Song Zhang Guoxiang Cai Peiyi Xie Caixia Sun Bao Li Weixing Dai Xiangyu Liu Qi Qiu Yang Du Zhenhui Li Zhenyu Liu Jie Tian Source Type: research
Biological function, regulatory mechanism, and clinical application of mannose in cancer
Biochim Biophys Acta Rev Cancer. 2023 Aug 30:188970. doi: 10.1016/j.bbcan.2023.188970. Online ahead of print.ABSTRACTStudies examining the regulatory roles and clinical applications of monosaccharides other than glucose in cancer have been neglected. Mannose, a common type of monosaccharide found in human body fluids and tissues, primarily functions in protein glycosylation rather than carbohydrate metabolism. Recent research has demonstrated direct anticancer effects of mannose in vitro and in vivo. Simply supplementing cell culture medium or drinking water with mannose achieved these effects. Moreover, mannose enhances t...
Source: Biochimica et Biophysica Acta - September 1, 2023 Category: Biochemistry Authors: Haoyi Jin Xi Liu Hong-Xu Liu Source Type: research
Hepatocellular carcinoma: Preclinical and clinical applications of nanotechnology with the potential role of carbohydrate receptors
Biochim Biophys Acta Gen Subj. 2023 Aug 11:130443. doi: 10.1016/j.bbagen.2023.130443. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common types of liver cancer; accounts for 75-85% of cases. The treatment and management of HCC involve different sanative options like surgery, chemotherapy, immunotherapy, etc. Recently, various advancements have been introduced for the diagnosis and targeting of hepatic tumor cells. Among these, biomarkers are considered the primary source for the diagnosis and differentiation of tumor cells. With the advancement in the field of nanotechnology, different ty...
Source: Biochimica et Biophysica Acta - August 13, 2023 Category: Biochemistry Authors: Sanya Batheja Rakesh Kumar Sahoo Sofiya Tarannum Klaudi K Vaiphei Shikha Jha Amit Alexander Amit Kumar Goyal Umesh Gupta Source Type: research
Tumor selective self-assembled nanomicelles of carbohydrate-epothilone B conjugate for targeted chemotherapy
Eur J Med Chem. 2023 Jul 29;259:115693. doi: 10.1016/j.ejmech.2023.115693. Online ahead of print.ABSTRACTEpothilone B (Epo B) is a potent antitumor natural product with sub-nanomolar anti-proliferation action against several human cancer cells. However, poor selectivity to tumor cells and unacceptable therapeutic windows of Epo B and its analogs are the major obstacles to their development into clinical drugs. Herein, we present self-assembled nanomicelles based on an amphiphilic carbohydrate-Epo B conjugate that is inactive until converted to active Epo B within the tumor. Four Epo B-Rhamnose conjugates linked via two lin...
Source: European Journal of Medicinal Chemistry - August 2, 2023 Category: Chemistry Authors: Yuliang Xu Lilin Qian Min Fang Yue Liu Ze-Jun Xu Xiaoyan Ge Zhiyue Zhang Zhao-Peng Liu Hongxiang Lou Source Type: research
Efficacy and safety of SOXIRI < em > versus < /em > mFOLFIRINOX in advanced pancreatic cancer
CONCLUSIONS: For locally advanced or metastatic pancreatic cancer patients, the SOXIRI regimen had similar efficacy and controllable safety compared with the mFOLFIRINOX regimen.PMID:37435561 | PMC:PMC10331348 | DOI:10.1177/17588359231186029
Source: Cancer Control - July 12, 2023 Category: Cancer & Oncology Authors: Xujia Li Jinsheng Huang Fenghua Wang Qi Jiang Lingli Huang Shengping Li Guifang Guo Source Type: research
Recovery from FOLFOX Chemotherapy-induced Systemic and Skeletal Muscle Metabolic Dysfunction in Mice
Am J Physiol Endocrinol Metab. 2023 Jun 28. doi: 10.1152/ajpendo.00096.2023. Online ahead of print.ABSTRACTFOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is used to treat colorectal cancer and can acutely induce metabolic dysfunction. However, the lasting effects on systemic and skeletal muscle metabolism after treatment cessation are poorly understood. Therefore, we investigated the acute and lasting effects of FOLFOX chemotherapy on systemic and skeletal muscle metabolism in mice. Direct effects of FOLFOX in cultured myotubes were also investigated. Male C57BL/6J mice completed four cycles (acute) of FOLFO...
Source: Am J Physiol Endocri... - June 28, 2023 Category: Endocrinology Authors: Jessica L Halle Brittany R Counts Hector G Paez Dryden R Baumfalk Quan Zhang Junaith S Mohamed Evan S Glazer Melissa J Puppa Ashley J Smuder Stephen E Alway James A Carson Source Type: research
