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Specialty: Molecular Biology
Nutrition: Calcium
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Total 1461 results found since Jan 2013.
Oxalate ‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling < em > in vitro < /em > and < em > in vivo < /em >
Mol Med Rep. 2023 Nov;28(5):209. doi: 10.3892/mmr.2023.13096. Epub 2023 Sep 21.ABSTRACTCalcium oxalate kidney stone has become an urgent issue due to its high incidence and recurrence rate. Thus, it is necessary to explore for mechanisms of calcium oxalate stones formation. Previous studies demonstrated that oxalate crystals could induce the activation of nucleotide‑binding domain and leucine‑rich repeat‑containing family pyrin domain‑containing 3 (NLRP3) inflammasome and change the renal tubular epithelium adhesion. However, the type and molecular mechanism of NLRP3 inflammasome‑mediated calcium oxalate stones f...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Yue Chen Shushuai Yang Hailong Kong Qi Wang Shiqun Chen Xingyu Wang Liqun Chen Shiyong Qi Source Type: research
Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
In conclusion, C5aR1 inhibition is proposed as a therapeutic option with the potential to exert long-term protective effect on PIPN-associated neuropathic pain and inflammation.PMID:37722320 | DOI:10.1016/j.cyto.2023.156370
Source: Cytokine - September 18, 2023 Category: Molecular Biology Authors: C Cristiano C Giorgio P Cocchiaro S Boccella M C Cesta V Castelli F M Liguori M R Cuozzo L Brandolini R Russo M Allegretti Source Type: research
High glucose-induced imbalance of mitochondria-associated ER membranes function promotes RSC96 cell damage
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):138-142. doi: 10.14715/cmb/2023.69.7.22.ABSTRACTTo investigate the effect of high glucose on mitochondrial-related ER membranes (MAMs) in rat Schwann cells (SCs) and the mechanism of cell injury. SCs (RSC96) cells were used as the control group, and RSC96 cells cultured in a high glucose environment for 48 h were set as the experimental group. The level of intracellular calcium was observed by flow cytometry, and ROS levels were detected by DCFH-DA fluorescent probe. The subcellular structure was observed by transmission electron microscopy, focusing on the morphology of mi...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Housheng Fu Jianbing Xu Fei Wang Weifu Wang Zhongyao Wang Source Type: research
Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long-chain acylcarnitines and calcium handling
J Cell Mol Med. 2023 Sep 8. doi: 10.1111/jcmm.17949. Online ahead of print.NO ABSTRACTPMID:37688368 | DOI:10.1111/jcmm.17949
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Hamish M Aitken-Buck Ei Phyo Khaing Regis R Lamberts Peter P Jones Source Type: research
The involvement of transient receptor potential channels in mast cell activation by microbubbles
This study was to explore the activation of mast cells by microbubbles, with the focus on transient receptor potential (TRP) channels mediated degranulation and calcium influx. Bone marrow-derived mast cells (BMMCs) were primarily obtained from femurs in mice and induced differentiation for 4 weeks. After the purity identification, BMMCs were contacted by homogeneous microbubbles with the diameter of 1 mm for 1 h. β-hexosaminidase and histamine levels in supernatants were assessed by enzyme-linked immunosorbent assay (ELISA) and the CD63 expression was tested by flow cytometry. The intracellular calcium binding with Fluo-...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jia Liu Long Qing Yufei He Qihui Zhu Weigang Xu Jianhua Wu Source Type: research
