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Total 34 results found since Jan 2013.
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Statin use and risk of colorectal cancer in patients with inflammatory bowel disease
EClinicalMedicine. 2023 Aug 24;63:102182. doi: 10.1016/j.eclinm.2023.102182. eCollection 2023 Sep.ABSTRACTBACKGROUND: Statin use has been linked to a reduced risk of advanced colorectal adenomas, but its association with colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) - a high risk population for CRC - remains inconclusive.METHODS: From a nationwide IBD cohort in Sweden, we identified 5273 statin users and 5273 non-statin users (1:1 propensity score matching) from July 2006 to December 2018. Statin use was defined as the first filled prescription for ≥30 cumulative defined daily doses and follow...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Jiangwei Sun Jonas Halfvarson David Bergman Fahim Ebrahimi Bjorn Roelstraete Paul Lochhead Mingyang Song Ola Ol én Jonas F Ludvigsson Source Type: research
Optimal implementation of the 2019 ESC/EAS dyslipidaemia guidelines in patients with and without atherosclerotic cardiovascular disease across Europe: a simulation based on the DA VINCI study
Lancet Reg Health Eur. 2023 Jun 8;31:100665. doi: 10.1016/j.lanepe.2023.100665. eCollection 2023 Aug.ABSTRACTBACKGROUND: The impact of the stepwise implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) treatment algorithm on low-density lipoprotein cholesterol (LDL-C) goal attainment was simulated in patients from the DA VINCI study.METHODS: Monte Carlo simulation was used to evaluate treatment optimisation scenarios, based on a patient's risk category: statin intensification (step 1), addition of ezetimibe (step 2), and addition of a proprotein convertase subtilisin/kexin t...
Source: Atherosclerosis - August 7, 2023 Category: Cardiology Authors: Julia Brandts Sarah Bray Guillermo Villa Alberico L Catapano Neil R Poulter Antonio J Vallejo-Vaz Kausik K Ray DA VINCI study group Source Type: research
Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach
Lancet Reg Health Am. 2023 Jun 22;23:100534. doi: 10.1016/j.lana.2023.100534. eCollection 2023 Jul.ABSTRACTBACKGROUND: The digitization of the primary care system provides an opportunity to evaluate the current use of statins in secondary prevention populations (myocardial infarction or stroke).METHODS: We conducted a cross-sectional study (ClinicalTrials.gov, NCT05285085), analysing anonymised data routinely collected by community health workers (CHW) in Brazil between May 2016 and September 2021 to assess the proportion of self-reported statins use and associated factors.FINDINGS: From the 2,133,900 individuals on the da...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: M Julia Machline-Carrion Alysson Nathan Girotto Josu é Nieri Pedro Marton Pereira Frederico Monfardini Francisco Forestiero Priscila Raupp Fabiana Roveda Karla Santo Ot ávio Berwanger Raul D Santos Source Type: research
Lipoprotein(a) and carotid intima-media thickness in children with familial hypercholesterolaemia in the Netherlands: a 20-year follow-up study
Lancet Diabetes Endocrinol. 2023 Jul 21:S2213-8587(23)00156-0. doi: 10.1016/S2213-8587(23)00156-0. Online ahead of print.ABSTRACTBACKGROUND: Elevated lipoprotein(a) and familial hypercholesterolaemia are both independent risk conditions for cardiovascular disease. Although signs of atherosclerosis can be observed in children with familial hypercholesterolaemia, it is unknown whether elevated lipoprotein(a) is an additional risk factor for atherosclerosis in these young patients. Therefore, we aimed to assess the contribution of lipoprotein(a) concentrations to arterial wall thickening (as measured by carotid intima-media t...
Source: Atherosclerosis - July 24, 2023 Category: Cardiology Authors: Lotte M de Boer Albert Wiegman Jeffrey Kroon Sotirios Tsimikas Calvin Yeang Merel C Peletier Alma Revers John J P Kastelein Aeilko H Zwinderman Barbara A Hutten Source Type: research
Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study
This study is funded by Daiichi Sankyo Europe GmbH, Munich, Germany.PMID:37090089 | PMC:PMC10119631 | DOI:10.1016/j.lanepe.2023.100624
Source: Atherosclerosis - April 24, 2023 Category: Cardiology Authors: Kausik K Ray Inaam Haq Aikaterini Bilitou Marius C Manu Annie Burden Carlos Aguiar Marcello Arca Derek L Connolly Mats Eriksson Jean Ferri ères Ulrich Laufs Jose M Mostaza David Nanchen Ernst Rietzschel Timo Strandberg Hermann Toplak Frank L J Visseren A Source Type: research
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Use of statins for the prevention of cardiovascular disease in 41 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data
The objectives of this study were to benchmark statin use in LMICs and to investigate country-level and individual-level characteristics associated with statin use.METHODS: We did a cross-sectional analysis of pooled, individual-level data from nationally representative health surveys done in 41 LMICs between 2013 and 2019. Our sample consisted of non-pregnant adults aged 40-69 years. We prioritised WHO Stepwise Approach to Surveillance (STEPS) surveys because these are WHO's recommended method for population monitoring of non-communicable disease targets. For countries in which no STEPS survey was available, a systematic ...
Source: Cancer Control - February 18, 2022 Category: Cancer & Oncology Authors: Maja E Marcus Jennifer Manne-Goehler Michaela Theilmann Farshad Farzadfar Sahar Saeedi Moghaddam Mohammad Keykhaei Amirali Hajebi Scott Tschida Julia M Lemp Krishna K Aryal Matthew Dunn Corine Houehanou Silver Bahendeka Peter Rohloff Rifat Atun Till W B Ã Source Type: research
Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study
The objective of this study was to assess the clinical and genetic characteristics, as well as the impact, of current practice on health outcomes of HoFH patients globally.METHODS: The HoFH International Clinical Collaborators registry collected data on patients with a clinical, or genetic, or both, diagnosis of HoFH using a retrospective cohort study design. This trial is registered with ClinicalTrials.gov, NCT04815005.FINDINGS: Overall, 751 patients from 38 countries were included, with 565 (75%) reporting biallelic pathogenic variants. The median age of diagnosis was 12·0 years (IQR 5·5-27·0) years. Of the 751 patien...
Source: Atherosclerosis - February 1, 2022 Category: Cardiology Authors: Tycho R Tromp Merel L Hartgers G Kees Hovingh Antonio J Vallejo-Vaz Kausik K Ray Handrean Soran Tomas Freiberger Stefano Bertolini Mariko Harada-Shiba Dirk J Blom Frederick J Raal Marina Cuchel Homozygous Familial Hypercholesterolaemia International Clini Source Type: research
Reducing Nontraumatic Lower-Extremity Amputations by 20% by 2030: Time to Get to Our Feet: A Policy Statement From the American Heart Association
Circulation. 2021 Mar 25:CIR0000000000000967. doi: 10.1161/CIR.0000000000000967. Online ahead of print.ABSTRACTNontraumatic lower-extremity amputation is a devastating complication of peripheral artery disease (PAD) with a high mortality and medical expenditure. There are ≈150 000 nontraumatic leg amputations every year in the United States, and most cases occur in patients with diabetes. Among patients with diabetes, after an ≈40% decline between 2000 and 2009, the amputation rate increased by 50% from 2009 to 2015. A number of evidence-based diagnostic and therapeutic approaches for PAD can reduce amputation risk. Ho...
Source: Circulation - March 25, 2021 Category: Cardiology Authors: Mark A Creager Kunihiro Matsushita Shipra Arya Joshua A Beckman Sue Duval Philip P Goodney J Antonio T Gutierrez John A Kaufman Karen E Joynt Maddox Amy W Pollak Aruna D Pradhan Laurie P Whitsel American Heart Association Advocacy Coordinating Committee Source Type: research
