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Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patients...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Microbial Diversity and Antimicrobial Resistance Profile in Microbiota From Soils of Conventional and Organic Farming Systems
According to this study it may be outlined that soil microbiota is a stable component as it were detected similar composition of microorganisms in soil both in organic as well as in conventional farming systems with similar soil structure and pH. The different amount of phosphorus in soils had no influence on bacterial variety at a genera level although more investigations would be useful to investigate changes among separate species. During evolution microorganisms adapted to survive in ecosystems independently of certain changes and probably serve as a buffer for ecological niches. It is unclear, however, what level of i...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli
This study of the RSHMex enzyme activity is the first direct biochemical demonstration that an RSH enzyme is capable of synthesizing a nucleotide derivative other than (p)ppGpp, i.e., pppApp. This is shown in vitro with the RSHMex1-352 protein (Figures 3, 4), as well as in vivo with E. coli cells induced to express full-length RSHMex and with wild type M. extorquens AM1 cells (Figure 6). Moreover, we demonstrate pppApp accumulation in wild type E. coli cells, which points to a possible new player in bacterial stringent response. In this work, it became evident to us that there may be a need to re-evaluate RSH nomenclature...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

New Genetic Loci Associated With Chronic Kidney Disease in an Indigenous Australian Population
This study also displayed evidence of association of variants in ACE and TP53 with ACR. Here we describe a classical genome-wide association study (GWAS) of Tiwi Islanders in which we identified several loci associated with markers of renal disease. Two of these loci, single nucleotide polymorphisms (SNPs) rs443816 located in the gene encoding UGT2B11 and rs4016189 located in the gene encoding CRIM1, were also significantly associated with the renal disease phenotype in an independently sampled cohort. Materials and Methods Sample Collection In the 1990s, in close consultation with the Tiwi Land Council, the protocol w...
Source: Frontiers in Genetics - April 15, 2019 Category: Genetics & Stem Cells Source Type: research

A Visual Introduction to SENS Rejuvenation Research
The SENS Research Foundation has assembled a set of narrated cellular biochemistry animations that serve as an introduction to the various distinct projects that make up the field of rejuvenation biotechnology. The videos outline the forms of cell and tissue damage that are the root cause of aging and age-related disease, as well as the classes of therapy that could, once constructed, either repair that damage or bypass it entirely. Since aging is exactly an accumulation of damage and the consequences of that damage, repair of the damage is the basis for rejuvenation, the reversal and prevention of degenerative aging and a...
Source: Fight Aging! - September 15, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Assessing the extent to which current clinical research is consistent with patient priorities: a scoping review using a case study in patients on or nearing dialysis
Abstract Purpose of review There is growing acknowledgement that engaging patients to identify their research priorities is important. Using a case study of patients on or nearing dialysis, we sought to assess the extent to which recently completed and ongoing clinical research was consistent with priorities identified by patients, caregivers, and clinicians. Sources of information Over a 4-year sampling frame (January 2010 to December 2013), we systematically searched the medical literature (top 5 nephrology and top 10 general medicine journals ...
Source: Canadian Journal of Kidney Health and Disease - October 1, 2015 Category: Urology & Nephrology Source Type: research