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Management: National Institutes of Health (NIH)
Procedure: Liver Transplant
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Total 15 results found since Jan 2013.
The improving Medication Adherence in Adolescents and young adults following Liver Transplantation (iMALT) multisite trial: Design and trial implementation considerations
DISCUSSION: Improving Medication Adherence in adolescent Liver Transplant includes several innovative design elements. The use of a validated, objective adherence index to survey a large cohort of transplant recipients allows the teams to avoid bias inherent in both convenience sampling and referral-based recruitment and enroll only patients whose computed index indicates substantially increased risk of rejection. The remote intervention paradigm helps to engage patients who are by definition hard to engage. The use of an objective, masked medical (rather than behavioral) outcome measure reduces the likelihood of biases re...
Source: Clinical Trials - June 3, 2023 Category: Research Authors: Eyal Shemesh Sarah Duncan-Park George Mazariegos Rachel Annunziato Ravinder Anand Miguel Reyes-Mugica Jeff Mitchell Benjamin L Shneider for iMALT Source Type: research
Gastrointestinal and Hepatic Manifestations of Chronic Granulomatous Disease
J Allergy Clin Immunol Pract. 2023 Jan 13:S2213-2198(23)00050-8. doi: 10.1016/j.jaip.2022.12.039. Online ahead of print.ABSTRACTChronic granulomatous disease (CGD) is a rare inborn error of immunity, resulting from a defect in nicotinamide adenine dinucleotide phosphate (NADPH) oxidation and decreased production of phagocyte reactive oxygen species. The main clinical manifestations are recurrent infections and chronic inflammatory disorders. Current approaches to management include antimicrobial prophylaxis and control of inflammatory complications. Hematopoietic stem cell transplantation (HSCT) or gene therapy can provide...
Source: Cancer Control - January 16, 2023 Category: Cancer & Oncology Authors: Alexander H Yang Brigit Sullivan Christa S Zerbe Suk See De Ravin Andrew M Blakely Martha M Quezado Beatriz E Marciano Jamie Marko Alexander Ling David E Kleiner John I Gallin Harry L Malech Steven M Holland Theo Heller Source Type: research
Results of Multicenter Phase II Study With Imatinib Mesylate in Allogeneic Recipients With Steroid-Refractory Chronic GVHD
Cell Transplant. 2022 Jan-Dec;31:9636897221113789. doi: 10.1177/09636897221113789.ABSTRACTIn this multicenter phase II study, we evaluated the safety and efficacy of imatinib in patients with steroid-resistant chronic graft-versus-host disease (cGVHD) and evaluated the quality of life (QOL) of the enrolled patients using the Short Form 36 (SF-36) health survey questionnaire. Thirty-six patients who were diagnosed with steroid-refractory cGVHD and treated with imatinib between March 2013 and February 2019 received 100 mg/day of imatinib for 2 weeks. Depending on the patient's condition and investigator's decision, the imati...
Source: Cell Transplantation - July 21, 2022 Category: Cytology Authors: Dong Won Baek Hee Jeong Cho Ju-Hyung Kim Jae Sook Ahn Hyeoung-Joon Kim Sung Nam Lim Jun Won Cheong Sung-Yong Kim Ho Sup Lee Jong Ho Won Ho-Young Yhim Sang Kyun Sohn Joon Ho Moon Source Type: research
Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Renaissance Radiologists: Meet AJ Gunn, MD
AJ Gunn, M.D. graduated magna cum laude from Brigham Young University in Provo, UT, earning a BS in exercise physiology with a minor in sociology. He then returned home to South Dakota to attend medical school at the University of South Dakota. During medical school, he participated in the competitive Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program and was awarded the Donald L. Alcott, M.D. Award for Clinical Promise. He graduated summa cum laude in 2009. He completed his diagnostic radiology residency at the Massachusetts General Hospital of Harvard Medical School in Boston, MA ...
Source: radRounds - February 21, 2020 Category: Radiology Authors: Robin Pine Miles Source Type: blogs
Renaissance Rad Feature: Meet AJ Gunn, MD
AJ Gunn, M.D. graduated magna cum laude from Brigham Young University in Provo, UT, earning a BS in exercise physiology with a minor in sociology. He then returned home to South Dakota to attend medical school at the University of South Dakota. During medical school, he participated in the competitive Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program and was awarded the Donald L. Alcott, M.D. Award for Clinical Promise. He graduated summa cum laude in 2009. He completed his diagnostic radiology residency at the Massachusetts General Hospital of Harvard Medical School in Boston, MA ...
Source: radRounds - February 21, 2020 Category: Radiology Authors: Robin Pine Miles Source Type: blogs
He ’s the First African American to Receive a Face Transplant. His Story Could Change Health Care
Robert Chelsea turned down the first face he was offered. It was a fine face, one that could have taken him off the transplant waiting list after just a couple months. But Chelsea—severely disfigured after a catastrophic car accident five years earlier—was in no hurry. He’d gotten used to tilting his head back so food and water wouldn’t fall out of his nearly lipless mouth. He knew how to respond compassionately to children who stared in shock and fear. The face, offered in May 2018, had belonged to a man with skin that was much fairer than what remained of Chelsea’s—so light that Chelse...
Source: TIME: Health - October 24, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Healthcare Source Type: news
Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics!
The amazing journey of genome sequencing
Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs
Government Appropriation Of Breakthrough Drug Patent Rights Would Deter Biopharmaceutical R&D And Innovation
In the May 2016 issue of Health Affairs, Amy Kapezynski and Aaron Kesselheim propose that the federal government invoke its patent use authority under Section 1498 to lower drug prices and increase access for breakthrough medicines in government-funded health care programs. Section 1498 allows the government eminent domain-type powers to circumvent an inventor’s patent exclusivity rights in exchange for “reasonable and entire compensation” — in effect a royalty on sales which would be determined through negotiation or by the courts.
To date, application of Section 1498 has been limited to selective military and...
Source: Health Affairs Blog - June 20, 2016 Category: Health Management Authors: Henry Grabowski Tags: Costs and Spending Drugs and Medical Technology Big Pharma Cooperative Research and Development Agreements eminent domain hepatitis C Section 1498 Sovaldi Source Type: blogs
