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Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop
Am J Prev Cardiol. 2022 Nov 13;12:100430. doi: 10.1016/j.ajpc.2022.100430. eCollection 2022 Dec.ABSTRACTMore than half of U.S. young adults have low ten-year but high lifetime risk of cardiovascular disease (CVD). Improving primary prevention in young adulthood may help reduce persistent CVD disparities and overall CVD morbidity and mortality. The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop in 2021 to identify potential trial opportunities in CVD prevention in young adults. The workshop identified promising interventions that could be tested, including interventions that focus on a single cardiova...
Source: Atherosclerosis - November 28, 2022 Category: Cardiology Authors: Ann Marie Navar Lawrence J Fine Walter T Ambrosius Arleen Brown Pamela S Douglas Karen Johnson Amit V Khera Donald Lloyd-Jones Erin D Michos Mahasin Mujahid Daniel Mu ñoz Khurram Nasir Nicole Redmond Paul M Ridker Jennifer Robinson David Schopfer Deborah Source Type: research

Gene Therapy for Niemann-Pick Disease Type C
Investigators at the National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH) are seeking collaborators to further develop viral gene therapy to treat Niemann-Pick Disease Type C (NPC). NPC is a rare and fatal, autosomal recessive, neurodegenerative disease that can present in infants, children, or adults. Most patients with NPC have mutations in NPC1, a gene implicated in intracellular cholesterol trafficking, which results in intracellular accumulation of unesterified cholesterol in late edosomal/lysosomal structures and of glycosphingolipids, especially in neuronal tissue. Thus, NPC pa...
Source: NIH OTT Licensing Opportunities - May 29, 2020 Category: Research Authors: ajoyprabhu3 Source Type: research

Kcnab1 Is Expressed in Subplate Neurons With Unilateral Long-Range Inter-Areal Projections
In this study, we analyzed the corticocortical projections of L6b/SP neurons in the mouse cortex and searched for a marker gene expressed in L6b/SP neurons that have ipsilateral inter-areal projections. Retrograde tracing experiments demonstrated that L6b/SP neurons in the primary somatosensory cortex (S1) projected to the primary motor cortex (M1) within the same cortical hemisphere at postnatal day (PD) 2 but did not show any callosal projection. This unilateral projection pattern persisted into adulthood. Our microarray analysis identified the gene encoding a β subunit of voltage-gated potassium channel (Kcnab1)...
Source: Frontiers in Neuroanatomy - May 2, 2019 Category: Neurology Source Type: research

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

Techniques for Studying Decoding of Single Cell Dynamics
Stevan Jeknić1,2†, Takamasa Kudo2,3† and Markus W. Covert1,2,3* 1Department of Bioengineering, Stanford University, Stanford, CA, United States 2Allen Discovery Center for Systems Modeling of Infection, Stanford, CA, United States 3Department of Chemical and Systems Biology, Stanford University, Stanford, CA, United States Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The ...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research