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Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Efficacy and safety of a fourth dose of the COVID-19 vaccine in kidney transplant recipients: A systematic review and meta-analysis
CONCLUSIONS: The fourth dose of the COVID-19 vaccine was well tolerated in KTRs with no serious adverse effects. Some KTRs showed a reduced response even after receiving the fourth vaccine dose. Overall, the fourth vaccine dose effectively improved seropositivity in KTRs, as recommended by the World Health Organization for the general population.PMID:37230397 | PMC:PMC10205136 | DOI:10.1016/j.trim.2023.101864
Source: Transplant Immunology - May 25, 2023 Category: Transplant Surgery Authors: Yasen Kuniduzi Bo Chen Jingjing Zeng Xiaosong Sun Tao Chen Xiaoyuan Qian Jiange Wang Fuchao Liang Rukeya Abuduxukuer Maierhaba Yusufu Shaoyong Xu Xuejun Zhang Source Type: research

A subtractive proteomics and immunoinformatics approach towards designing a potential multi-epitope vaccine against pathogenic Listeriamonocytogenes
Microb Pathog. 2022 Sep 20:105782. doi: 10.1016/j.micpath.2022.105782. Online ahead of print.ABSTRACTListeria monocytogenes is the causative agent of listeriosis, which is dangerous for pregnant women, the elderly or individuals with a weakened immune system. Individuals with leukaemia, cancer, HIV/AIDS, kidney transplant and steroid therapy suffer from immunological damage are menaced. World Health Organization (WHO) reports that human listeriosis has a high mortality rate of 20-30% every year. To date, no vaccine is available to treat listeriosis. Thereby, it is high time to design novel vaccines against L. monocytogenes...
Source: Cancer Control - September 23, 2022 Category: Cancer & Oncology Authors: Shakilur Rahman Amit Kumar Das Source Type: research

National Epidemiological Study about Hepatitis C Virus Infection among Dialysis Patients
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1715-1721. doi: 10.4103/1319-2442.352433.ABSTRACTThe World Health Organization estimates that 3% of the general population is infected with this virus. Hepatitis C remains the main viral infection in dialysis patients, and the severity of this infection is the risk of developing cirrhosis or hepatocarcinoma. We aim to determine the prevalence of hepatitis C in dialysis patients, to calculate the rate of hepatitis C virus (HCV) seroconversion, and to identify the risk factors for seroconversion. This is a nationwide multicenter observational study including all dialysis patient...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Meriam Hajji Samia Barbouch Rihab Manaa Khaoula Ajimi Fethi Ben Ben Hamida Rym Goucha Imen Gorsane Taieb Ben Abdallah Source Type: research

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