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Therapy: Antibiotic Therapy
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Total 1281 results found since Jan 2013.
Bacteriological profile and frequency of antibiotic resistance in the infected diabetic foot
This study aimed to establish the bacteriological profile of diabetic foot infection and to evaluate the resistance of isolated bacteria to antibiotics. Retrospective study of 150 patients in the internal medicine departments of the University Hospital of Batna, the University Hospital of Constantine and the EPH of Oum El Bouaghi, over 24 months from September 2019 to August 2021. The population had an average age of 46±13 years and a sex ratio of 1.88 in favour of men. The majority of patients were type 2 diabetics with a mean duration of the evolution of 20 years. The starting point of the foot lesions was inter-toe int...
Source: Mol Biol Cell - August 12, 2023 Category: Molecular Biology Authors: Samira Fetni Ammar Ouahab Fatma Hamlaoui Source Type: research
Hidden consequences: Uncovering belimumab's role in the development of < em > Pneumocystis jirovecii < /em > pneumonia in a lupus patient
DISCUSSION: Our report demonstrates the first confirmed case of pneumocystis jirovecii pneumonia in a patient with B cell depletion due to chronic maintenance therapy with belimumab. Our patient's diagnosis of PJP was unexpected, given her normal CD4+ count and the use of such a low dose of prednisone. We attribute her susceptibility to PJP infection to her profound B cell depletion in response to her belimumab therapy, supporting previous research indicating the importance of CD4+ T cells and B cells in the protective immune response against PJP. This case may help shape future clinical guidelines concerning PJP prophylax...
Source: Lupus - July 27, 2023 Category: Rheumatology Authors: Maria Ng Meggan Mackay Pranisha Gautam-Goyal Sameer Goyal Praveen Kumar Vikraman Source Type: research
Phage Therapy for Diabetic Foot Infection: A Case Series
This article reports the provision of topical adjunctive anti-staphylococcal phage therapy to 10 patients with DFI at high risk of amputation at two UK hospitals as part of clinical care; tolerability and efficacy were clinically assessed.FINDINGS: The opinion of the experienced clinical teams caring for these patients was that 9 of the 10 patients appeared to benefit from adjunctive phage therapy. No adverse effects were reported by clinicians or patients. In 6 of 10 patients the clinical impression was that phage therapy facilitated clinical resolution of infection and limb salvage. Resolution of soft tissue infection wa...
Source: Clinical Therapeutics - July 13, 2023 Category: Drugs & Pharmacology Authors: Matthew J Young Lesley M L Hall Maya Merabishvilli Jean-Paul Pirnay Jason R Clark Joshua D Jones Source Type: research
Association between Antibiotic Exposure and the Risk of Rash in Children with Infectious Mononucleosis: a Multicenter, Retrospective Cohort Study
Antimicrob Agents Chemother. 2023 May 23:e0024923. doi: 10.1128/aac.00249-23. Online ahead of print.ABSTRACTPresent evidence suggests that the administration of antibiotics, particularly aminopenicillins, may increase the risk of rash in children with infectious mononucleosis (IM). This retrospective, multicenter cohort study of children with IM was conducted to explore the association between antibiotic exposure in IM children and the risk of rash. A robust error generalized linear regression was performed to address the potential cluster effect, as well as confounding factors such as age and sex. A total of 767 children ...
Source: Antimicrobial Agents and Chemotherapy - May 23, 2023 Category: Microbiology Authors: Rui Zhang Zhen Mao Chang Xu Wen Wang Joey Sum-Wing Kwong Minjie Xu Yi Song Tianyi Lv Zhiyuan Teng Ruifeng Zhong Hui Liu Yang Liu Qin Wang Ying Wang Yuan Zhang Shuya Chen Xiuli Chai Rui He Wenyi Zheng Jiaxing Zhang Source Type: research
Comparison of Oral and Intravenous Definitive Antibiotic Therapy for Beta-Hemolytic Streptococcus Species Bloodstream Infections from Soft Tissue Sources: a Propensity Score-Matched Analysis
Antimicrob Agents Chemother. 2023 May 16:e0012023. doi: 10.1128/aac.00120-23. Online ahead of print.ABSTRACTBeta-hemolytic streptococci are common causes of bloodstream infection (BSI). There is emerging data regarding oral antibiotics for BSI but limited for beta-hemolytic streptococcal BSI. We conducted a retrospective study of adults with beta-hemolytic streptococcal BSI from a primary skin/soft tissue source from 2015 to 2020. Patients transitioned to oral antibiotics within 7 days of treatment initiation were compared to those who continued intravenous therapy, after propensity score matching. The primary outcome was ...
Source: Antimicrobial Agents and Chemotherapy - May 16, 2023 Category: Microbiology Authors: Zachary A Yetmar Supavit Chesdachai Brian D Lahr Douglas W Challener Kellie N Arensman Hannan Kevin Epps Ryan W Stevens Maria Teresa Seville Aaron J Tande Abinash Virk Source Type: research
Case Series of Granulicatella Bacteremia: A Single-centered, Five-year Retrospective Study
Acta Med Okayama. 2023 Apr;77(2):203-207. doi: 10.18926/AMO/65151.ABSTRACTGranulicatella species are rare, nutritionally variant streptococci that cause infective endocarditis. Their clinical and microbiological characteristics remain unknown. We reviewed five years of Granulicatella cases in our hospital database (Jan 2017-Jun 2022), finding 6 Granulicatella adiacens cases and 1 Granulicatella elegans case. Clinical backgrounds and bacteremia sources were diverse; 3 cases developed polymicrobial bacteremia. Antimicrobial testing showed non-susceptibility to penicillin G in 4 of 7 cases (57.1%), and high susceptibility to ...
Source: Acta Med Okayama - April 24, 2023 Category: Universities & Medical Training Authors: Shinnosuke Fukushima Hideharu Hagiya Koji Iio Hiroyuki Honda Tomoharu Ishida Hirokazu Nagaoka Kou Hasegawa Fumio Otsuka Source Type: research
