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Total 53221 results found since Jan 2013.
Correlation of microsatellite status and EBV infection with clinical characteristics of patients with gastric cancer
This study was designed to investigate the correlation of microsatellite status (MS) and Epstein-Barr virus (EBV) infection with the clinical characteristics of gastric cancer (GC) patients. MS was detected by immunohistochemistry. EBV was detected by in situ hybridization. There were 31.3% cases showed mismatch repair-deficient (dMMR)/ microsatellite instability (MSI) and 68.7% cases showed mismatch repair-proficient (pMMR)/ microsatellite stability (MSS). The dMMR/MSI was more common in the elderly, in patients with cardia GC, smaller tumor diameter or non-poorly differentiated carcinoma. The survival in dMMR/MSI patient...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Pengfei Lu Kadeliya Yushan Gulimilai Yusufu Hiu Wang Rui Mao Source Type: research
ROS/RNS as molecular signatures of chronic liver diseases
Trends Mol Med. 2023 Sep 11:S1471-4914(23)00186-7. doi: 10.1016/j.molmed.2023.08.001. Online ahead of print.ABSTRACTThe liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological conditions is detrimental to all liver constituents. Chronic oxidative stress coupled to unresolved inflammation sets in motion the activation of profibrogenic hepatic stellate cells (HSCs) and later pathogenesis of liver fibrosis, cirrhosis, and liver cancer. The liver antioxid...
Source: Trends in Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Zhaodi Che Ziyuan Zhou Si-Qi Li Lei Gao Jia Xiao Nai-Kei Wong Source Type: research
Approach to nail trauma for primary care physicians
CONCLUSION: Fingertips are essential to normal hand function. Nail trauma is common and can be managed by primary care physicians. Shared decision making concerning management is based on the mechanism and extent of the injury and aims to prevent secondary deformities.PMID:37704235 | PMC:PMC10498896 | DOI:10.46747/cfp.6909609
Source: Canadian Family Physician Medecin de Famille Canadien - September 13, 2023 Category: Primary Care Authors: Ann-Sophie Lafreniere Griffins Misati Aaron Knox Source Type: research
Correlation of microsatellite status and EBV infection with clinical characteristics of patients with gastric cancer
This study was designed to investigate the correlation of microsatellite status (MS) and Epstein-Barr virus (EBV) infection with the clinical characteristics of gastric cancer (GC) patients. MS was detected by immunohistochemistry. EBV was detected by in situ hybridization. There were 31.3% cases showed mismatch repair-deficient (dMMR)/ microsatellite instability (MSI) and 68.7% cases showed mismatch repair-proficient (pMMR)/ microsatellite stability (MSS). The dMMR/MSI was more common in the elderly, in patients with cardia GC, smaller tumor diameter or non-poorly differentiated carcinoma. The survival in dMMR/MSI patient...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Pengfei Lu Kadeliya Yushan Gulimilai Yusufu Hiu Wang Rui Mao Source Type: research
Approach to nail trauma for primary care physicians
CONCLUSION: Fingertips are essential to normal hand function. Nail trauma is common and can be managed by primary care physicians. Shared decision making concerning management is based on the mechanism and extent of the injury and aims to prevent secondary deformities.PMID:37704235 | PMC:PMC10498896 | DOI:10.46747/cfp.6909609
Source: Canadian Family Physician Medecin de Famille Canadien - September 13, 2023 Category: Primary Care Authors: Ann-Sophie Lafreniere Griffins Misati Aaron Knox Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
Approach to nail trauma for primary care physicians
CONCLUSION: Fingertips are essential to normal hand function. Nail trauma is common and can be managed by primary care physicians. Shared decision making concerning management is based on the mechanism and extent of the injury and aims to prevent secondary deformities.PMID:37704235 | PMC:PMC10498896 | DOI:10.46747/cfp.6909609
Source: Canadian Family Physician Medecin de Famille Canadien - September 13, 2023 Category: Primary Care Authors: Ann-Sophie Lafreniere Griffins Misati Aaron Knox Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
Correlation of microsatellite status and EBV infection with clinical characteristics of patients with gastric cancer
This study was designed to investigate the correlation of microsatellite status (MS) and Epstein-Barr virus (EBV) infection with the clinical characteristics of gastric cancer (GC) patients. MS was detected by immunohistochemistry. EBV was detected by in situ hybridization. There were 31.3% cases showed mismatch repair-deficient (dMMR)/ microsatellite instability (MSI) and 68.7% cases showed mismatch repair-proficient (pMMR)/ microsatellite stability (MSS). The dMMR/MSI was more common in the elderly, in patients with cardia GC, smaller tumor diameter or non-poorly differentiated carcinoma. The survival in dMMR/MSI patient...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Pengfei Lu Kadeliya Yushan Gulimilai Yusufu Hiu Wang Rui Mao Source Type: research
Immune Dysfunction from Radiation Exposure
Radiat Res. 2023 Sep 13. doi: 10.1667/RADE-22-00197.1. Online ahead of print.ABSTRACTExposure to ionizing radiation causes acute damage and loss of bone marrow and peripheral immune cells that can result in high mortality due to reduced resistance to infections and hemorrhage. Besides these acute effects, tissue damage from radiation can trigger inflammatory responses, leading to progressive and chronic tissue damage by radiation-induced loss of immune cell types that are required for resolving tissue injuries. Understanding the mechanisms involved in radiation-induced immune system injury and repair will provide new insig...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: David R Cassatt Thomas A Winters Mercy PrabhuDas Source Type: research
Viruses, Vol. 15, Pages 1919: Characterization and Comparative Genomic Analysis of a Deep-Sea Bacillus Phage Reveal a Novel Genus
In this study, vB_BteM-A9Y, a novel bacteriophage infecting Bacillus tequilensis, was isolated from deep-sea sediments in the South China Sea. vB_BteM-A9Y has a hexametric head and a long, complex contractile tail, which are typical features of myophages. vB_BteM-A9Y initiated host lysis at 60 min post infection with a burst size of 75 PFU/cell. The phage genome comprises 38,634 base pairs and encodes 54 predicted open reading frames (ORFs), of which 27 ORFs can be functionally annotated by homology analysis. Interestingly, abundant ORFs involved in DNA damage repair were identified in the phage genome, sugges...
Source: Viruses - September 13, 2023 Category: Virology Authors: Yuan Chen Tianyou Zhang Qiliang Lai Menghui Zhang Meishun Yu Runying Zeng Min Jin Tags: Article Source Type: research
From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering
Phys Chem Chem Phys. 2023 Sep 12. doi: 10.1039/d3cp00921a. Online ahead of print.ABSTRACTOsteoarthritis caused by articular cartilage defects is a particularly common orthopedic disease that can involve the entire joint, causing great pain to its sufferers. A global patient population of approximately 250 million people has an increasing demand for new therapies with excellent results, and tissue engineering scaffolds have been proposed as a potential strategy for the repair and reconstruction of cartilage defects. The precise control and high flexibility of 3D printing provide a platform for subversive innovation. In this...
Source: Health Physics - September 12, 2023 Category: Physics Authors: Hewen Zhang Meng Wang Rui Wu Jianjun Guo Aihua Sun Zhixiang Li Ruqing Ye Gaojie Xu Yuchuan Cheng Source Type: research
