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Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia
Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women.
Source: Atherosclerosis - September 2, 2021 Category: Cardiology Authors: Marianne Klevmoen, Martin P. Bogsrud, Kjetil Retterst øl, Tone Svilaas, Elisabeth K. Vesterbekkmo, Anders Hovland, Christ Berge, Jeanine Roeters van Lennep, Kirsten B. Holven Source Type: research

Statins and breastfeeding in familial hypercholesterolaemia.
PMID: 28551957 [PubMed - in process]
Source: Tidsskrift for den Norske Laegeforening - May 1, 2017 Category: General Medicine Authors: Holmsen ST, Bakkebø T, Seferowicz M, Retterstøl K Tags: Tidsskr Nor Laegeforen Source Type: research

CME/Answers: Familial Hypercholesterolemia - Statin  Treatment during Pregnancy and Breastfeeding.
[CME/Answers: Familial Hypercholesterolemia - Statin Treatment during Pregnancy and Breastfeeding]. Praxis (Bern 1994). 2020;109(7):546-547 Authors: Shala-Haskaj P, Krähenmann F, Schmidt D PMID: 32456586 [PubMed - in process]
Source: Praxis - May 29, 2020 Category: General Medicine Authors: Shala-Haskaj P, Krähenmann F, Schmidt D Tags: Praxis (Bern 1994) Source Type: research

Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database
ConclusionIn this retrospective cohort of men undergoing RP, postoperative statin use was significantly associated with reduced risk of BCR.Whether the association between postoperative statin use and BCR differs by race requires further study.Given these findings, coupled with other studies suggesting that statins may reduce risk of advanced PC, randomized controlled trials are warranted to formally test the hypothesis that statins slow PC progression.
Source: BJU International - March 3, 2014 Category: Urology & Nephrology Authors: Emma H. Allott, Lauren E. Howard, Matthew R. Cooperberg, Christopher J. Kane, William J. Aronson, Martha K. Terris, Christopher L. Amling, Stephen J. Freedland Tags: Urological Oncology Source Type: research

In search of the optimal setting for statin trials in prostate cancer: the power of population-based studies
Prostate Cancer and Prostatic Diseases, Published online: 29 March 2021; doi:10.1038/s41391-021-00355-yIn search of the optimal setting for statin trials in prostate cancer: the power of population-based studies
Source: Prostate Cancer and Prostatic Diseases - March 29, 2021 Category: Urology & Nephrology Authors: Emma H. Allott Emma L. Craig Konrad H. Stopsack Source Type: research

Maternal Medication Transmission through Human Milk
As breastfeeding rates have risen in the United States during the past decade, pediatric practitioners are frequently faced with questions from expecting and lactating parents regarding the safety of maternal medication use while breastfeeding. For the purpose of this article, we reference mothers and women because most available research has focused on individuals who identify as female, although the concepts apply to any lactating parent. The practitioner must balance the harm of the mother's untreated condition with any potential medication risk to the infant as well as consider the benefits of breastfeeding itself on m...
Source: Pediatrics in Review - January 28, 2022 Category: Pediatrics Source Type: research

The Potential Impact of Statins in the Treatment of Patients with COVID-19 Infection
CONCLUSION: Patients with SARS-CoV-2 infection have a high risk of cardiovascular and thrombotic complications and pleiotropic effects of statins may help manage the COVID-19. There is growing evidence that supports the need for trials of statin treatment in COVID-19 infection.PMID:35132599 | DOI:10.1007/978-3-030-85109-5_9
Source: Atherosclerosis - February 8, 2022 Category: Cardiology Authors: Reza Jafarzadeh Esfehani Mohammad Vojdanparast Saman Soleimanpour Gordon A Ferns Amir Avan Source Type: research

SLCO1B1 Polymorphisms and Statin-Induced Myopathy
Clinical scenario Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors which reduce the risk of coronary events and death by lowering blood concentrations of low density lipoprotein cholesterol (LDL-c).1,2,3,4 They are generally regarded as safe and well tolerated. However, some patients experience adverse muscle symptoms; these are mostly relatively mild but, in rare cases, severe muscle damage with renal failure (rhabdomyolysis) may occur (reviewed in 5,6). Recently, an autoimmune form of necrotising myositis has also been identified as a rare statin-associated myopathy (reviewed in 7). There ...
Source: PLOS Currents Evidence on Genomic Tests - December 4, 2013 Category: Genetics & Stem Cells Authors: Alison Stewart Source Type: research

IJERPH, Vol. 19, Pages 16736: Burden of Neurological Diseases in the Philippines as Revealed by Web Searches: An Infodemiological Study
This study evaluated the population’s interest in neurological disorders by using search volumes related to neurology, either disease diagnosis or medications. Bid values generated in API were used as a proxy for the interests of the healthcare industry. Spearman’s rank-order correlation was performed between search volumes and bid prices to determine significance. Among the neurologic diseases listed, the most searched were attention deficit hyperactivity disorder, migraine, and Alzheimer’s disease. The most commonly searched drugs were oral antihypertensives (amlodipine, losartan...
Source: International Journal of Environmental Research and Public Health - December 13, 2022 Category: Environmental Health Authors: Anisah Hayaminnah D. Alonto Almira Doreen Abigail O. Apor Roland Dominic G. Jamora Tags: Article Source Type: research

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
CONCLUSIONS: Based on the findings of this review, which included two trials with high risk of bias and a small numbers of participants, it seems possible that statins may improve serum aminotransferase levels as well as ultrasound findings. Neither of the trials reported on possible histological changes, liver-related morbidity or mortality. Trials with larger sample sizes and low risk of bias are necessary before we may suggest statins as an effective treatment for patients with NASH. However, as statins can improve the adverse outcomes of other conditions commonly associated with NASH (for example, hyperlipidaemia, diab...
Source: Cochrane Database of Systematic Reviews - December 27, 2013 Category: Journals (General) Authors: Eslami L, Merat S, Malekzadeh R, Nasseri-Moghaddam S, Aramin H Tags: Cochrane Database Syst Rev Source Type: research

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association
Circulation. 2021 Mar 29:CIR0000000000000961. doi: 10.1161/CIR.0000000000000961. Online ahead of print.ABSTRACTThis statement summarizes evidence that adverse pregnancy outcomes (APOs) such as hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-for-gestational-age delivery, placental abruption, and pregnancy loss increase a woman's risk of developing cardiovascular disease (CVD) risk factors and of developing subsequent CVD (including fatal and nonfatal coronary heart disease, stroke, peripheral vascular disease, and heart failure). This statement highlights the importance of recognizing APOs...
Source: Circulation - March 29, 2021 Category: Cardiology Authors: Nisha I Parikh Juan M Gonzalez Cheryl A M Anderson Suzanne E Judd Kathryn M Rexrode Mark A Hlatky Erica P Gunderson Jennifer J Stuart Dhananjay Vaidya American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombos Source Type: research