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Total 78693 results found since Jan 2013.
Lactation prescription plus acupoint stimulation improves breastfeeding quality and alleviates breast tenderness in parturients undergoing cesarean section
CONCLUSION: Lactation prescription plus acupoint stimulation has a positive effect on improving the breastfeeding quality of parturients after CS and relieving breast tenderness, which is worth promoting clinically.PMID:36777860 | PMC:PMC9908465
Source: Cell Research - February 13, 2023 Category: Cytology Authors: Jinlai Zhan Nan Huang Ning Meng Yafen Qiu Yin Zhu Yiran Xu Xiangjun Chen Source Type: research
Breastfeeding promotes oligodendrocyte precursor cells in a demyelinated region of the corpus callosum
Brain Res. 2023 Sep 15:148584. doi: 10.1016/j.brainres.2023.148584. Online ahead of print.ABSTRACTDemyelination alters the conduction of neuronal signals and hampers sensory-motor functions. Experimental and clinical evidence suggest that breastfeeding exerts a promyelinating impact on the maternal brain. The mechanism underlying this neuroprotective effect is not well-understood. In the present paper, we assessed the impact of rat lactation on lysolecithin-induced demyelination injury within the corpus callosum of lactating and non-lactating postpartum rats. We show that lactation enhanced the cell density of oligodendroc...
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Abdeslam Mouihate Samah Kalakh Source Type: research
MS Ana: Improving Sensitivity in Peptide Identification with Spectral Library Search
We describe MS Ana, a new spectral library search engine that enables high sensitivity peptide identification using either curated or predicted spectral libraries as well as robust false discovery control through its own decoy library generation algorithm. MS Ana identifies on average 36% more spectrum matches and 4% more proteins than database search in a benchmark test on single-shot human cell-line data. Further, we demonstrate the quality of the result validation with tests on synthetic peptide pools and show the importance of library selection through a comparison of library search performance with different configura...
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Sebastian Dorl Stephan Winkler Karl Mechtler Viktoria Dorfer Source Type: research
Large scale similarity search across digital reconstructions of neural morphology
Neurosci Res. 2022 May 14:S0168-0102(22)00139-0. doi: 10.1016/j.neures.2022.05.004. Online ahead of print.ABSTRACTMost functions of the nervous system depend on neuronal and glial morphology. Continuous advances in microscopic imaging and tracing software have provided an increasingly abundant availability of 3D reconstructions of arborizing dendrites, axons, and processes, allowing their detailed study. However, efficient, large-scale methods to rank neural morphologies by similarity to an archetype are still lacking. Using the NeuroMorpho.Org database, we present a similarity search software enabling fast morphological c...
Source: Cell Research - May 17, 2022 Category: Cytology Authors: Bengt Ljungquist Masood A Akram Giorgio A Ascoli Source Type: research
Target search by an imported conjugative DNA element for a unique integration site along a bacterial chromosome during horizontal gene transfer
Nucleic Acids Res. 2023 Feb 10:gkad068. doi: 10.1093/nar/gkad068. Online ahead of print.ABSTRACTIntegrative and conjugative elements (ICEs) are mobile genetic elements that can transfer by conjugation to recipient cells. Some ICEs integrate into a unique site in the genome of their hosts. We studied quantitatively the process by which an ICE searches for its unique integration site in the Bacillus subtilis chromosome. We followed the motion of both ICEBs1 and the chromosomal integration site in real time within individual cells. ICEBs1 exhibited a wide spectrum of dynamical behaviors, ranging from rapid sub-diffusive displ...
Source: Cell Research - February 10, 2023 Category: Cytology Authors: Rinat Arbel-Goren Saria A McKeithen-Mead Dominik Voglmaier Idana Afremov Gianluca Teza Alan D Grossman Joel Stavans Source Type: research
Why Argonaute is needed to make microRNA target search fast and reliable.
Publication date: Available online 26 May 2016 Source:Seminars in Cell & Developmental Biology Author(s): Misha Klein, Stanley D. Chandradoss, Martin Depken, Chirlmin Joo MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated ...
Source: Seminars in Cell and Developmental Biology - May 25, 2016 Category: Cytology Source Type: research
Why Argonaute is needed to make microRNA target search fast and reliable
Publication date: Available online 26 May 2016 Source:Seminars in Cell & Developmental Biology Author(s): Misha Klein, Stanley D. Chandradoss, Martin Depken, Chirlmin Joo MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated ...
Source: Seminars in Cell and Developmental Biology - June 6, 2016 Category: Cytology Source Type: research
HRGRN: A Graph Search-Empowered Integrative Database of Arabidopsis Signaling Transduction, Metabolism and Gene Regulation Networks
The biological networks controlling plant signal transduction, metabolism and gene regulation are composed of not only tens of thousands of genes, compounds, proteins and RNAs but also the complicated interactions and co-ordination among them. These networks play critical roles in many fundamental mechanisms, such as plant growth, development and environmental response. Although much is known about these complex interactions, the knowledge and data are currently scattered throughout the published literature, publicly available high-throughput data sets and third-party databases. Many ‘unknown’ yet important int...
Source: Plant and Cell Physiology - January 21, 2016 Category: Cytology Authors: Dai, X., Li, J., Liu, T., Zhao, P. X. Tags: Special Online Collection - Database Papers Source Type: research
In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.
Abstract
Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure, functional implications of that feature and its structural prerequisites remain unclear. In a search for unstable PAs, we probed conformational stability of parvalbumin β-1 from coho salmon (csPA), a cold water fish species, using circular dichroism, scanning calorimetry, hydrophobic probe fluorescence, limited proteolysis, chemical crosslinking and dynamic light scattering techniques. Apo-csPA is shown to be mainly monomeric ...
Source: Cell Calcium - October 17, 2017 Category: Cytology Authors: Vologzhannikova AA, Khorn PA, Kazakov AS, Ismailov RG, Sokolov AS, Uversky VN, Permyakov EA, Permyakov SE Tags: Cell Calcium Source Type: research
Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade
Publication date: 26 December 2017 Source:Cell Reports, Volume 21, Issue 13 Author(s): Chaoyou Xue, Yicheng Zhu, Xiangmei Zhang, Yeon-Kyun Shin, Dipali G. Sashital CRISPR-Cas systems defend bacteria and archaea against infection by bacteriophage and other threats. The central component of these systems are surveillance complexes that use guide RNAs to bind specific regions of foreign nucleic acids, marking them for destruction. Surveillance complexes must locate targets rapidly to ensure timely immune response, but the mechanism of this search process remains unclear. Here, we used single-molecule FRET to visualize how th...
Source: Cell Reports - December 27, 2017 Category: Cytology Source Type: research
Anti-sine-cosine atom search optimization (ASCASO): a novel approach for parameter estimation of PV models
Environ Sci Pollut Res Int. 2023 Aug 24. doi: 10.1007/s11356-023-28777-2. Online ahead of print.ABSTRACTNowadays, solar power generation has gradually become a part of electric energy sharing. How to effectively enhance the energy conversion efficiency of solar cells and components has gradually emerged as a focal point of research. This paper presents a boosted atomic search optimization (ASO) with a new anti-sine-cosine mechanism (ASCASO) to realize the parameter estimation of photovoltaic (PV) models. The anti-sine-cosine mechanism is inspired by the update principle of sine cosine algorithm (SCA) and the mutation strat...
Source: Cell Research - August 24, 2023 Category: Cytology Authors: Wei Zhou Pengjun Wang Xuehua Zhao Huiling Chen Source Type: research
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
Cell division is enacted by a microtubule-based, self-assembling macromolecular machine known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing dynamic cycles of growth and disassembly, microtubules search for chromosomes. Capture of microtubules by the kinetochores progressively connects chromosomes to the bipolar spindle. 30 years later, "search and capture" remains the cornerstone of spindle assembly. However, a variety of facilitating mechanisms such as regulation of microtubule dynamics by diffusible gradients, spatially selective motor activities, and adaptive changes in chromosome ...
Source: Journal of Cell Biology - December 22, 2015 Category: Cytology Authors: Heald, R., Khodjakov, A. Tags: Review Source Type: research
Grading lung neuroendocrine tumors: Controversies in search of a solution.
CONCLUSION: This new formulation of lung NET grading could have clinical relevance for the individual handling of patients.
PMID: 27628949 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - September 19, 2016 Category: Cytology Tags: Histol Histopathol Source Type: research
Profiling of Androgen-Dependent Enhancer RNAs Expression in Human Prostate Tumors: Search for Malignancy Transition Markers
CONCLUSION: Presented data suggest that prostate tumor development may associate with epigenetic reorganization in the KLK3 genomic regulatory elements reflected by changes of the KLK3eRNA expression. Our findings support a potential of eRNAs profiling to be used as diagnostic marker.PMID:34549035 | PMC:PMC8449685 | DOI:10.2147/RRU.S328661
Source: Cell Research - September 22, 2021 Category: Cytology Authors: Koichi Nishimura Jinichi Mori Takahiro Sawada Shuhei Nomura Alexander Kouzmenko Kaori Yamashita Yoshiaki Kanemoto Tomohiro Kurokawa Akira Hayakawa Suguru Tokiwa Michihisa Ochi Hiroaki Shimmura Shigeaki Kato Source Type: research
Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library
In conclusion, fulvestrant and dexmedetomidine hydrochloride increased MafA, PDX-1, or insulin expression levels in MIN6 cells and islets from nondiabetic mice and obese type 2 diabetic db/db mice. To the best of our knowledge, this is the first report showing some molecule which can enhance MafA and/or PDX-1 expression levels. Therefore, although further extensive study is necessary, we think that the information in this study could be, at least in part, useful at some point such as in the development of new antidiabetes medicine based on the molecular mechanism of β-cell glucose toxicity in the future.PMID:37720599 | PM...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hideaki Kaneto Atsushi Obata Masashi Shimoda Tomohiko Kimura Yoshiyuki Obata Tomoko Ikeda Saeko Moriuchi Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Source Type: research
