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Specialty: Transplant Surgery
Procedure: Heart Transplant

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Total 339 results found since Jan 2013.

Left ventricular assist systems and strokes: Statins to the rescue?
The development of durable left ventricular assist systems (LVASs) has been critical in providing an option for management of end-stage heart disease and addressing the increasing gap between demand and supply of donor cardiac allografts for management of end-stage heart disease. The technology also provides an alternative to heart transplantation in many patients. Unfortunately, the long-term use of LVASs has been associated with significant morbidities, the most devastating of which may relate to the thrombogenicity of the artificial devices, leading to ischemic stroke or pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - March 16, 2020 Category: Transplant Surgery Authors: Jignesh K. Patel Tags: EDITORIAL COMMENTARY Source Type: research

The Impact of Statin Therapy on Neurological Events Following Left Ventricular Assist System Implantation in Advanced Heart Failure
Stroke is a leading cause of disability and death in advanced heart failure patients supported with continuous-flow left ventricular assist systems (CF-LVAS). Statins (HMG-CoA Reductase Inhibitors) reduce the risk of major cardiovascular and neurological events, such as stroke, but their impact has not been evaluated in patients implanted with CF-LVAS. We sought to explore the association between use of statin therapy and subsequent occurrence of neurological events, particularly stroke, following CF-LVAS implantation.
Source: The Journal of Heart and Lung Transplantation - March 3, 2020 Category: Transplant Surgery Authors: Jefferson L. Vieira, Michael Pfeffer, Brian L. Claggett, Garrick C. Stewart, Michael M. Givertz, Lara Coakley, Hari R. Mallidi, Mandeep R. Mehra Tags: Original Clinical Science Source Type: research

Understanding Risk Factors and Predictors for Stroke Subtypes in the ENDURANCE Trials
We report a comprehensive analysis of stroke subtypes in the ENDURANCE (DT) and ENDURANCE Supplemental (DT2) trials.
Source: The Journal of Heart and Lung Transplantation - January 27, 2020 Category: Transplant Surgery Authors: Sung-Min Cho, Randall C. Starling, Jeffrey Teuteberg, Joseph Rogers, Francis Pagani, Palak Shah, Ken Uchino, Nicholas Hiivala Tags: Original Clinical Science Source Type: research

This is Your Brain on LVAD
The utilization and duration of left ventricular assist device (LVAD) support has increased steadily over the last decade and recent changes in the UNOS heart allocation system, implemented in October 2018, portend a further increase in the duration of mechanical circulatory support for many patients (1). Though four-year survival rates have improved to 60% following LVAD implantation, the leading cause of death in these patients is neurological injury, specifically ischemic and hemorrhagic stroke (spontaneous subarachnoid hemorrhage or intraparenchymal hemorrhage [IPH]) (2).
Source: The Journal of Heart and Lung Transplantation - January 24, 2020 Category: Transplant Surgery Authors: Jennifer A. Frontera Tags: Editorial Source Type: research

Haemodynamic evaluation of the new pulsatile-flow generation method in vitro.
Abstract Continuous-flow ventricular-assist devices are widely used to support patients with advanced heart failure, because continuous-flow ventricular-assist devices are more durable, have smaller sizes and have better survival rates for patients compared to the pulsatile-flow ventricular-assist devices. Nevertheless, continuous-flow ventricular-assist devices often cause complications such as gastrointestinal bleeding, haemorrhagic stroke, and aortic insufficiency and have a negative impact on the microcirculation for both long-time implantable and short-time extracorporeal systems. The aim of this study is the...
Source: The International Journal of Artificial Organs - October 10, 2019 Category: Transplant Surgery Authors: Itkin GP, Bychnev AS, Kuleshov AP, Drobyshev AA Tags: Int J Artif Organs Source Type: research

First Human Implantation of A Miniaturized Axial Flow Ventricular Assist Device in a Child with End-Stage Heart Failure
Small children with end-stage heart failure who require left ventricular assist device (LVAD) support to heart transplant have limited device options leading to high morbidity and mortality and chronic hospitalization until transplant.1,2 The only FDA-approved durable LVAD for children is a paracorporeal pulsatile device that carries a high stroke risk and lacks portability precluding hospital discharge.1 Temporary paracorporeal continuous flow (CF) devices have also been used off-label for bridge-to-transplant but carry higher mortality, require lengthy paracorporeal cannulas prone to circuit thrombus, and typically requi...
Source: The Journal of Heart and Lung Transplantation - September 10, 2019 Category: Transplant Surgery Authors: Antonio Amodeo, Sergio Filippelli, Gianluigi Perri, Roberta Iacobelli, Rachele Adorisio, Francesca Iodice, Alessandra Rizza, M. Patricia Massicotte, J. Timothy Baldwin, Christopher S.D. Almond Tags: Case Anecdotes, Comments and Opinions Source Type: research

Usefulness of right ventricular contraction pressure index to predict short-term mortality and right heart failure in patients who underwent continuous-flow left ventricular assist device implantation.
CONCLUSION: Right ventricular contraction pressure index was found as a useful parameter for determining short-term postoperative mortality in patients undergoing continuous-flow left ventricular assist device implantation. PMID: 31387423 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - August 6, 2019 Category: Transplant Surgery Authors: Kalenderoğlu K, Güvenç TS, Mete MT, Kuplay H, Ağustos S, Güzelburç ÖÇ, Yıldırımtürk Ö, Kozan Ö, Aka SA Tags: Int J Artif Organs Source Type: research

Peripheral Component Malfunction of a Fully Magnetically Levitated Centrifugal Pump Masquerading as Pump Thrombosis
We present the case of a HM-3 controller malfunction, resembling pump thrombosis based on acute changes to pump parameters and abnormal LVAD log file analysis.
Source: The Journal of Heart and Lung Transplantation - June 18, 2019 Category: Transplant Surgery Authors: Ioannis Mastoris, Mohamed El Khashab, Travis Abicht Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Ventricular Assist Device Deactivation in Children: Preparedness Planning and Procedural Checklist
Key difference exist between adult and pediatric Ventricular Assist Device (VAD) care. For many adult patients, VADs are commonly implanted as destination therapy in contrast to pediatric patients who more often receive VAD therapy as a bridge to transplant. Adult patients/families may be better prepared for the anticipated and enivadable complications that occur at the end of destination therapy, but receive benefit from VAD therapy for both prolonged quantity and quality of life. Despite the success of VAD as a bridge to heart transplantation in children, adverse and debilitating events, including stroke, thrombosis, inf...
Source: The Journal of Heart and Lung Transplantation - June 18, 2019 Category: Transplant Surgery Authors: Desiree S. Machado, Seth A. Hollander, Jenna Murray, Joseph Philip, Mark Bleiweis, Sheri Kittelson Tags: Letter to the Editor Source Type: research

Quantification of interventricular dyssynchrony during continuous-flow left ventricular assist device support
In this study, we evaluated seven goats (body weight 44.5  ± 6.5 kg) with normal hearts. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheters into the left ventricle (LV) and right ventricle (RV) to assess the volume signal simultaneously. We defined the interventricular dyssynchrony as a signal (increase o r decrease) of LV volume (LVV) change opposite to that of RV volume (RVV) (i.e., (dLVV/dt)  × (dRVV/dt)  <  0). The duration of interventricular dyssynchrony (DYS) was reported as the percentage of time that a heart was in a dyssynchronous state within a card...
Source: Journal of Artificial Organs - June 14, 2019 Category: Transplant Surgery Source Type: research

VCA Deceased Donors in the United States
Conclusions. donors are a demographically and clinically diverse group. Understanding this diversity and future trends in VCA donor characteristics is critical in supporting this life-changing field of transplantation.
Source: Transplantation - May 1, 2019 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Cessation of Anticoagulation for Bleeding and Thrombosis Events with a Fully Magnetically Levitated Centrifugal Left Ventricular Assist Device
Anticoagulation therapy for patients supported by a left ventricular assist device (LVAD) has not been adequately evaluated in relevance to newer pumps, such as the fully magnetically levitated HeartMate 3 pump. Current anticoagulation guidelines target a goal INR of 2.0 –3.0 with vitamin K antagonists to mitigate the risk of pump thrombosis and ischemic stroke, but are based on historical trials with older devices. Long-term outcomes associated with newer devices, such as the centrifugal-flow HeartMate 3 (HM3), have demonstrated a marked decrease in the incidence of pump thrombosis compared to mechanical bearing axial-f...
Source: The Journal of Heart and Lung Transplantation - April 28, 2019 Category: Transplant Surgery Authors: Igor Gosev, Brian Ayers, Katherine Wood, Bryan Barrus, Sunil Prasad Tags: Case Anecdotes, Comments and Opinions Source Type: research

Cessation of anti-coagulation for bleeding and subsequent thrombosis events with a fully magnetically levitated centrifugal left ventricular assist device
Anti-coagulation therapy for patients supported by a left ventricular assist device (LVAD) has not been adequately evaluated in relevance to newer pumps, such as the fully magnetically levitated HeartMate 3 (HM3) pump. Current anti-coagulation guidelines target a goal international normalized ratio (INR) of 2.0 to 3.0, with vitamin K antagonists to mitigate the risk of pump thrombosis and ischemic stroke, but are based on historical trials with older devices. Long-term outcomes associated with newer devices, such as the centrifugal-flow HM3, have demonstrated a marked decrease in the incidence of pump thrombosis compared w...
Source: The Journal of Heart and Lung Transplantation - April 28, 2019 Category: Transplant Surgery Authors: Igor Gosev, Brian Ayers, Katherine Wood, Bryan Barrus, Sunil Prasad Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Usefulness of antiplatelet therapy testing in children supported with a ventricular assist device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR ® Pediatric ventricular assist device (VAD).1-3 Thromboelastography with Platelet Mapping® (TEG/PM) has become the most commonly used platelet function test in US children supported with the EXCOR®4 after it was incorporated into the Edmonton Antithrombotic Guideline for the FDA Trial of the EXCO R® (Supplementary File).1 Despite its use, stroke occurred in one-third of children in the EXCOR® trial.1-3 Thus, some clinicians have questioned its validity as a primary means to guide antiplatelet therapy dosing in EXCOR® recipients.
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Lindsay J. May, Xiaoxi Liu, Tiffany Tesoro, Jaden Yang, Clara Lo, Sharon Chen, Jenna Murray, David N. Rosenthal, Alan D. Michelson, Christopher S. Almond Tags: Research Correspondence Source Type: research

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis
Ventricular assist device (VAD) patients often experience infections, which increase the risk of stroke and mortality. Using the definitions of the International Society for Heart and Lung Transplantation (ISHLT), we have characterized differences in clinical outcomes for categories of infection: VAD-specific (e.g., pump component related); VAD-related (e.g., bloodstream infection, BSI); and non-VAD infections (e.g., pneumonia).
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Palak Shah, Sarah E. Birk, Lauren B. Cooper, Mitchell A. Psotka, James K. Kirklin, Scott D. Barnett, Shalika B. Katugaha, Sheila Phillips, Mary M. Looby, Francis D. Pagani, Jennifer A. Cowger Tags: ORIGINAL CLINICAL SCIENCE Source Type: research