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Specialty: Molecular Biology
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Total 1564 results found since Jan 2013.
Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials
J Cell Mol Med. 2022 Jan 17. doi: 10.1111/jcmm.17189. Online ahead of print.ABSTRACTMitochondrial damage is a critical contributor to stroke-induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal survival via various adaptive responses for preserving mitochondria structure, morphology, quantity and function. The processes of mitochondrial fission and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of m...
Source: J Cell Mol Med - January 18, 2022 Category: Molecular Biology Authors: Heyan Tian Xiangyu Chen Jun Liao Tong Yang Shaowu Cheng Zhigang Mei Jinwen Ge Source Type: research
An In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke
Methods Mol Biol. 2022;2492:289-305. doi: 10.1007/978-1-0716-2289-6_17.ABSTRACTCerebral ischemic injury evokes a complex cascade of pathophysiological events at the blood-vascular-parenchymal interface. These evolve over time and space and result in progressive neurological damage. Emerging evidence suggests that blood-brain barrier (BBB) recovery and reestablishment of BBB impermeability are incomplete and that these could influence stroke injury recovery, increase the risk of new stroke occurrence, and be a solid substrate for developing vascular dementia. Recent work from the author's laboratory has established the exis...
Source: Molecular Medicine - June 22, 2022 Category: Molecular Biology Authors: Svetlana M Stamatovic Chelsea M Phillips Richard F Keep Anuska V Andjelkovic Source Type: research
The study of serum C-reactive protein, Serum cystatin C, and carbohydrate antigen 125 in patients with acute ischemic stroke
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):89-95. doi: 10.14715/cmb/2022.68.5.12.ABSTRACTStroke is the most common, deadly, and complicating neurological disease. Many studies have shown that the levels of some acute inflammatory reactants in people with ischemic stroke are higher than average. Therefore, in this study, three acute inflammatory reactants, i.e., C-reactive protein, Serum cystatin C, and carbohydrate antigen 125, were evaluated in patients with acute ischemic stroke to consider the association between these serums with intra and extra-cerebral vessels stenosis. In this cross-sectional study, 90 patien...
Source: Mol Biol Cell - August 27, 2022 Category: Molecular Biology Authors: Xiaoqian Lin Chunyu Yu Hongmei Ding Xiuping Ma Fengning Guo Dan Chen Youmin Fan Source Type: research
Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
Curr Mol Med. 2023 Apr 10. doi: 10.2174/1566524023666230410101724. Online ahead of print.ABSTRACTIschemic stroke is one of the major causes of global mortality, which puts great demands on health systems and social welfare. Ischemic stroke is a complex pathological process involving a series of mechanisms such as ROS accumulation, Ca2 + overload, inflammation, and apoptosis. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients has led scientists to find new treatments. The use of herbal medicine, as an alternative or complementary therapy, is increasing worldwide. For centurie...
Source: Current Molecular Medicine - April 11, 2023 Category: Molecular Biology Authors: Shakiba Azami Fatemeh Forouzanfar Source Type: research
Lipid profiles and atrial fibrillation in ischemic stroke patients treated with thrombectomy: experience from a tertiary Italian stroke hospital
CONCLUSION: Total cholesterol and all cholesterol-related measures were significantly lower in patients undergoing thrombectomy than in other stroke patients. Conversely, we found that AF was significantly high in patients with EVT, suggesting that hypercholesterolemia could be mainly linked to small-vessel occlusion stroke while large vessel occlusion (LVO) stroke could show different causes. AIS patients may have different pathogenesis and their understanding may improve enhance the discovery of specific and tailored preventive treatments.PMID:37221691 | DOI:10.2174/1871525721666230522124351
Source: Molecular Medicine - May 24, 2023 Category: Molecular Biology Authors: Maria Cristina Bravi Fabio Pilato Domenica Crupi Marilena Mangiardi Francesca Romana Pezzella Antonio Siniscalchi Enrico Cotroneo Luca Bertaccini Michele Alessiani Sabrina Anticoli Source Type: research
