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Specialty: Neurosurgery
Therapy: Stem Cell Therapy

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Total 83 results found since Jan 2013.

Clinical outcome and safety of stem cell therapy for ischemic stroke: A systematic review and meta-analysis
CONCLUSION: The results of this study show promising and satisfying efficacy and a relatively low rate of serious adverse events.PMID:35673677 | PMC:PMC9168316 | DOI:10.25259/SNI_1174_2021
Source: Surgical Neurology International - June 8, 2022 Category: Neurosurgery Authors: Andhika Tomy Permana Abdul Hafid Bajamal Muhammad Arifin Parenrengi Nur Setiawan Suroto Pudji Lestari Asra Al Fauzi Source Type: research

Stem cell therapy: A clinical trial of stroke
This study evaluates safety, feasibility and efficacy of autologous mononuclear and mesenchymal cell transplantation in stroke patients evaluated on clinical scores and functional imaging (fMRI and DTI).Methods: Forty (n=40) stroke patients were recruited with the inclusion criteria as: 3 months to 2 years of index event, power of hand muscles of at least 2; Brunnstrom stage: 2–5; conscious and comprehendible. Fugl Meyer (FM), modified Barthel Index (mBI), Medical Research Council (MRC) grade for strength, Ashworth tone scale and functional imaging was used for assessments at baseline, 8 weeks and 24 weeks. 50–60 milli...
Source: Clinical Neurology and Neurosurgery - November 26, 2012 Category: Neurosurgery Authors: Ashu Bhasin, M.V. Padma Srivastava, Sujata Mohanty, Rohit Bhatia, Senthil S. Kumaran, Sushmita Bose Tags: Original articles Source Type: research

Stem cell transplantation enhances endogenous brain repair after experimental stroke.
Authors: Horie N, Hiu T, Nagata I Abstract Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogene...
Source: Neurologia Medico-Chirurgica - June 3, 2015 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Stem Cell Transplantation Enhances Endogenous Brain Repair after Experimental Stroke.
Authors: Horie N, Hiu T, Nagata I Abstract Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogene...
Source: Neurologia Medico-Chirurgica - August 5, 2015 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model.
CONCLUSIONSThe transplantation approach described here is expected to provide not only a paracrine effect but also a direct cell effect resulting in cell replacement that protects the damaged neurovascular unit. The behavioral improvement seen with this transplantation approach provides the basis for further research on cell sheet-based regenerative treatment as a translational treatment for patients with stroke. PMID: 30797215 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 22, 2019 Category: Neurosurgery Authors: Ryu B, Sekine H, Homma J, Kobayashi T, Kobayashi E, Kawamata T, Shimizu T Tags: J Neurosurg Source Type: research

Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia
CONCLUSIONS: These results indicate that repeated systemic administration of MSCs over 3 weeks resulted in greater functional improvement as compared to single administration and/or vehicle infusion. In addition, administration of MSCs is associated with promotion of interhemispheric connectivity through the CC in the chronic phase of cerebral infarction.PMID:34861644 | DOI:10.3171/2021.8.JNS21687
Source: Journal of Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Mitsuhiro Takemura Masanori Sasaki Yuko Kataoka-Sasaki Ryo Kiyose Hiroshi Nagahama Shinichi Oka Ryo Ukai Takahiro Yokoyama Jeffery D Kocsis Tetsuya Ueba Osamu Honmou Source Type: research

Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats.
CONCLUSIONS Infused MSCs may inhibit endothelial dysfunction to suppress hemorrhagic events and facilitate functional outcome. Combined therapy of infused MSCs after rtPA therapy facilitated early behavioral recovery. PMID: 28059661 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2017 Category: Neurosurgery Authors: Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Namioka T, Namioka A, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O Tags: J Neurosurg Source Type: research