Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia

CONCLUSIONS: These results indicate that repeated systemic administration of MSCs over 3 weeks resulted in greater functional improvement as compared to single administration and/or vehicle infusion. In addition, administration of MSCs is associated with promotion of interhemispheric connectivity through the CC in the chronic phase of cerebral infarction.PMID:34861644 | DOI:10.3171/2021.8.JNS21687

Source: Journal of Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Mitsuhiro Takemura Masanori Sasaki Yuko Kataoka-Sasaki Ryo Kiyose Hiroshi Nagahama Shinichi Oka Ryo Ukai Takahiro Yokoyama Jeffery D Kocsis Tetsuya Ueba Osamu Honmou Source Type: research