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Etiology of first‐ever ischaemic stroke in European young adults: the 15 cities young stroke study
ConclusionsThe etiology of IS in young adults has clear gender‐specific patterns that change with age. A notable portion of these patients remains without an evident stroke mechanism according to TOAST criteria.
Source: European Journal of Neurology - July 10, 2013 Category: Neurology Authors: N. Yesilot Barlas, J. Putaala, U. Waje‐Andreassen, S. Vassilopoulou, K. Nardi, C. Odier, G. Hofgart, S. Engelter, A. Burow, L. Mihalka, M. Kloss, J. Ferrari, R. Lemmens, O. Coban, E. Haapaniemi, N. Maaijwee, L. Rutten‐Jacobs, A. Bersano, C. Cereda, P. Tags: Original Article Source Type: research

Ischemic Stroke in Pregnancy and Postpartum: A Descriptive Case Series (P1.079)
CONCLUSIONS: In our series of 19 pregnancy-associated ischemic strokes, mechanisms appeared unrelated to traditional vascular risk factors, and there was a substantial proportion of poor outcomes. Strokes were commonest in the 12 weeks postpartum, almost one third of which occurred following a miscarriage. Further exploration with a larger cohort is planned.Disclosure: Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Willey has nothing to disclose. Dr. Elkind has received personal compensation for activities with BMS-Pfizer Partnership, Janssen Pharmaceuticals, ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Miller, E., Yaghi, S., Boehme, A., Willey, J., Elkind, M., Marshall, R. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

Unusual Intersection: Elucidating the Role of Erdheim Chester Disease in Stroke (P4.366)
Conclusion:A unifying diagnosis of ECD was identified for this gentleman presenting with a stroke in the setting of critical ICA stenosis. Pathology from his CEA suggests that while ECD involves multisystem inflammation, it did not appear to play a direct role in his stroke.Disclosure: Dr. Sheikhi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sheikhi, L. Tags: Cerebrovascular Case Reports Source Type: research

Serum-Based Proteomics Reveals Lipid Metabolic and Immunoregulatory Dysregulation in Cervical Artery Dissection With Stroke
In conclusion, proteomic analysis reveals that early perturbation of immunoregulation and lipid metabolism may be involved in the pathophysiology of CAD. Specifically, the panel of six proteins identified is promising as serum-based biomarkers for the detection of increased CAD risk in stroke subjects.
Source: Frontiers in Neurology - May 18, 2020 Category: Neurology Source Type: research

Cervical artery dissection: Trauma and other potential mechanical trigger events
Conclusion: PCT seems to be an important environmental determinant of CeAD, but was not an independent outcome predictor. Because of the characteristics of most PCTs, the term mechanical trigger event rather than trauma may be more appropriate.
Source: Neurology - May 20, 2013 Category: Neurology Authors: Engelter, S. T., Grond-Ginsbach, C., Metso, T. M., Metso, A. J., Kloss, M., Debette, S., Leys, D., Grau, A., Dallongeville, J., Bodenant, M., Samson, Y., Caso, V., Pezzini, A., Bonati, L. H., Thijs, V., Gensicke, H., Martin, J. J., Bersano, A., Touze, E., Tags: Stroke in young adults, Other trauma, Carotid artery dissection ARTICLE Source Type: research

Cervical Artery Dissection in Young Adults in the Stroke in Young Fabry Patients (sifap1) Study
Background: Patients with carotid artery dissection (CAD) have been reported to have different vascular risk factor profiles and clinical outcomes to those with vertebral artery dissection (VAD). However, there are limited data from recent, large international studies comparing risk factors and clinical features in patients with cervical artery dissection (CeAD) with other TIA or ischemic stroke (IS) patients of similar age and sex. Methods: We analysed demographic, clinical and risk factor profiles in TIA and IS patients ≤55 years of age with and without CeAD in the large European, multi-centre, Stroke In young FAbry Pa...
Source: Cerebrovascular Diseases - January 23, 2015 Category: Neurology Source Type: research

Stroke Due To Extracranial Internal Carotid Artery Dissection After Roller Coaster Rides In A 4-Year-Old Boy (P7.343)
CONCLUSIONS: To our knowledge this is the youngest patient with stroke secondary to ICA dissection following roller-coaster rides. Although the exact mechanism of injury leading to ICA dissection in the setting of sudden linear acceleration, deceleration and rotational forces such as those experienced while riding a roller coaster is not fully understood, these injuries have been attributed to brief sustained excessive gravitational forces likely augmented among predisposed individuals. Children may be at higher risk due to the immature anatomy of their cervical spine. Alterations to roller coaster ride dynamics and use of...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nouh, A., Vela-Duarte, D., Grobelny, T., Hoganson, G., Pasquale, D., Biller, J. Tags: Child Neurology and Developmental Neurology VI Source Type: research

Clinical import of Horner syndrome in internal carotid and vertebral artery dissection
Conclusion: In patients with ICAD, HS is an easily assessable marker that might indicate a more benign clinical course. HS had no prognostic meaning in patients with VAD.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Lyrer, P. A., Brandt, T., Metso, T. M., Metso, A. J., Kloss, M., Debette, S., Leys, D., Caso, V., Pezzini, A., Bonati, L. H., Thijs, V., Bersano, A., Touze, E., Gensicke, H., Martin, J. J., Lichy, C., Tatlisumak, T., Engelter, S. T., Grond-Ginsbach, C., F Tags: Stroke in young adults, Carotid artery dissection ARTICLE Source Type: research

Case Misclassification in Studies of Spinal Manipulation and Arterial Dissection
Background: Spinal manipulation has been associated with cervical arterial dissection and stroke but a causal relationship has been questioned by population-based studies. Earlier studies identified cases using International Classification of Diseases Ninth Revision (ICD-9) codes specific to anatomic stroke location rather than stroke etiology. We hypothesize that case misclassification occurred in these previous studies and an underestimation of the strength of the association. We also predicted that case misclassification would differ by patient age.Methods: We identified cases in the Veterans Health Administration datab...
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Xuemei Cai, Ali Razmara, Jessica K. Paulus, Karen Switkowski, Pari J. Fariborz, Sergey D. Goryachev, Leonard D'Avolio, Edward Feldmann, David E. Thaler Tags: Original Articles Source Type: research

Endovascular management and outcome of acute middle cerebral artery stroke in the setting of spontaneous carotid dissection (P1.012)
Conclusion: This study provides additional evidence that endovascular management of carotid artery dissection in acute middle cerebral artery is effective and safe to maintain distal revascularization. Revascularization can be achieved with a combination of stenting, large catheter mediated angioplasty and thrombectomy. Further studies are warranted to investigate the role of endovascular recanalization for this stroke subtypeDisclosure: Dr. Gulati has nothing to disclose. Dr. Aghaebrahim has nothing to disclose. Dr. Ducruet has nothing to disclose. Dr. Jankowitz has nothing to disclose. Dr. Jovin has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gulati, D., Aghaebrahim, A., Ducruet, A., Jankowitz, B., Jovin, T., Jadhav, A. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study
Conclusions: This case-control study supports the hypothesis that a history of migraine, particularly with aura, is associated with a no-mismatch pattern during acute ischemic stroke, consistent with data obtained in migraine mutant mice.
Source: Neurology - November 30, 2015 Category: Neurology Authors: Mawet, J., Eikermann-Haerter, K., Park, K.-Y., Helenius, J., Daneshmand, A., Pearlman, L., Avery, R., Negro, A., Velioglu, M., Arsava, E. M., Ay, H., Ayata, C. Tags: Migraine, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Intraarterial Treatment for Acute Ischemic Stroke: Analysis of Outcomes of Dissection vs. Non-Dissection Mechanism in 445 patients (P4.380)
Conclusions: Intraarterial treatment appears to be as safe and effective when used in patients with ischemic stroke due to CAD as in AIS patients with other causes. Following the major advances in IAT for AIS in the general population, IAT should be considered in patients with AIS due to a CAD.Disclosure: Dr. Jensen has nothing to disclose. Dr. Salottolo has nothing to disclose. Dr. McCarthy has nothing to disclose. Dr. Loy has nothing to disclose. Dr. Frei has received personal compensation for activities with Microvention, Covidien, Stryker, Siemens, and Penumbra as a consultant. Dr. Wagner has received personal compensa...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jensen, J., Salottolo, K., McCarthy, K., Loy, D., Frei, D., Wagner, J., Whaley, M., Bar-Or, D. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Vertebral Artery Dissection in Rheumatoid Arthritis with Cervical Spine Disease
A 59-year-old woman with long-standing active rheumatoid arthritis presented with posterior circulation ischemic stroke after vertebral dissection. She had severe multilevel degenerative changes of her cervical spine. She did not have classic stroke risk factors nor evidence of atherosclerotic disease or other systemic diseases. The most likely mechanism appears to be injury of the artery wall by an osteophyte, causing dissection that resulted in thrombosis and subsequent embolic strokes.
Source: Journal of Stroke and Cerebrovascular Diseases - January 25, 2013 Category: Neurology Authors: Ritika Mahajan, Branko N. Huisa Tags: Case Reports Source Type: research

Spontaneous cervical internal carotid artery vasospasm: Case report and literature review
We report a case of recurrent TIA caused by alternating cervical ICA spasms. We also performed a MEDLINE search of previous publications in English from 1950 to August 2013. The search was performed with both text word searching and the appropriate MeSH headings of "carotid vasospasm" and "stroke," "cerebrovascular accident," "TIA," or "brain attack." The bibliographies of each of the retrieved articles with similar cases were all reviewed and relevant citations in these listings were evaluated for inclusion in the review.
Source: Nature Clinical Practice - October 13, 2014 Category: Neurology Authors: Huisa, B. N., Roy, G. Tags: Magnetic Source Imaging (MSI), Other cerebrovascular disease/ Stroke, Carotid artery dissection Cases Source Type: research

Familial occurrence and heritable connective tissue disorders in cervical artery dissection
Conclusions: In this largest series of patients with CeAD to date, family history of symptomatic CeAD was rare and inherited connective tissue disorders seemed exceptional. This finding supports the notion that CeAD is a multifactorial disease in the vast majority of cases.
Source: Neurology - November 24, 2014 Category: Neurology Authors: Debette, S., Goeggel Simonetti, B., Schilling, S., Martin, J. J., Kloss, M., Sarikaya, H., Hausser, I., Engelter, S., Metso, T. M., Pezzini, A., Thijs, V., Touze, E., Paolucci, S., Costa, P., Sessa, M., Samson, Y., Bejot, Y., Altintas, A., Metso, A. J., H Tags: Stroke in young adults, All Cerebrovascular disease/Stroke, Carotid artery dissection, Risk factors in epidemiology, All Genetics ARTICLE Source Type: research

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