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A systematic review and meta-regression analysis to examine the ‘timing hypothesis’ of hormone replacement therapy on mortality, coronary heart disease, and stroke
ConclusionYounger initiation of HRT may be effective in reducing death and cardiac events. However, younger HRT initiators remained at an increased risk of stroke, TIA and systemic embolism and this risk increased as average age increased. Younger menopausal women using HRT to treat vasomotor symptoms do not appear to be at an increased risk of dying or experiencing CHD events.
Source: IJC Heart and Vasculature - January 18, 2019 Category: Cardiology Source Type: research

Abstract 226: Strokes Worse in Women at 24 hours but Severity Reduced in Younger Women With Hormone Therapy Session Title: Poster Session II
Conclusion: Women in this study had more severe 24 hour AIS outcomes than men but this improved with HRT use in women younger than 80 years. This cannot be fully explained by age differences as there could be other underlying factors. Improving 24 hour NIHSS may correctly predict later outcomes following AIS. Further study of HRT use in AIS outcomes is justified.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Brown, A., Onteddu, S., Joiner, R., Benton, T., Culp, W., Lowery, C. Tags: Session Title: Poster Session II Source Type: research

Plasma Levels of the Proinflammatory Chitin-Binding Glycoprotein YKL-40, Variation in the Chitinase 3-Like 1 Gene (CHI3L1), and Incident Cardiovascular Events Epidemiology
Conclusions Among initially healthy U.S. women, plasma levels of the proinflammatory chitenase-like protein, YKL-40, were influenced by environmental as well as genetic factors and predicted incident thromboembolic stroke, but not MI, a differential effect consistent with limited previous data.
Source: JAHA:Journal of the American Heart Association - June 23, 2014 Category: Cardiology Authors: Ridker, P. M., Chasman, D. I., Rose, L., Loscalzo, J., Elias, J. A. Tags: Epidemiology Source Type: research

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life
Objectives:We assessed whether hypertension in pregnancy is associated with elevated C-reactive protein (CRP) levels in later life, possibly reflecting an increased risk of cardiovascular disease (CVD). Background:Elevated CRP levels have been associated with hypertension in pregnancy and with CVD. Methods:We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Participants were categorized as nulliparous women (n = 219), women with a history of normotensive pregnancies (n = 1839), or women with a history of a hypertensive pregnancy (n = 405). Using multiple linear regression ...
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Pregnancy Source Type: research

Mediterranean Diet Tied to Lowered Stroke Risk for Women (CME/CE)
(MedPage Today) -- Drop in risk occurred regardless of menopausal status or hormone replacement therapy
Source: MedPage Today Cardiovascular - September 20, 2018 Category: Cardiology Source Type: news

Sex differences of lipoprotein(a) levels and associated risk of morbidity and mortality by age: The Copenhagen General Population Study
CONCLUSIONS: Lipoprotein(a) levels increased modestly around age 50 selectively in women; however, risk of morbidity and mortality for high lipoprotein(a) was similar in women and men above age 50. This implies that elevated lipoprotein(a) above age 50 is a relatively more common cardiovascular risk factor in women, pointing toward repeat measurements in women above age 50.PMID:35803767 | DOI:10.1016/j.atherosclerosis.2022.06.1023
Source: Atherosclerosis - July 8, 2022 Category: Cardiology Authors: Sofie Bay Simony Martin B ødtker Mortensen Anne Langsted Shoaib Afzal Pia R ørbæk Kamstrup B ørge Grønne Nordestgaard Source Type: research