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Appropriateness of Oral Anticoagulants for the Long-Term Treatment of Atrial Fibrillation in Older People: Results of an Evidence-Based Review and International Consensus Validation Process (OAC-FORTA 2016)
ConclusionsAll non-vitamin K antagonist oral anticoagulants and warfarin were classified as beneficial or very beneficial in older persons (FORTA-A or -B), underlining the overall positive assessment of the risk/benefit ratio for these drugs. For other vitamin-K antagonists regionally used in Europe, the lack of evidence should challenge current practice.
Source: Drugs and Aging - May 10, 2017 Category: Geriatrics Source Type: research

Low intakes of carotene, vitamin  B2, pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial
ConclusionsThese findings suggest that sufficient intakes of carotene, vitamin B2, pantothenate, calcium and vegetables could help prevent cognitive decline among elderly men with diabetes mellitus. Geriatr Gerontol Int 2016; ••: ••–••.
Source: Geriatrics and Gerontology International - July 17, 2016 Category: Geriatrics Authors: Atsushi Araki, Yukio Yoshimura, Takashi Sakurai, Hiroyuki Umegaki, Chiemi Kamada, Satoshi Iimuro, Yasuo Ohashi, Hideki Ito, Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Use of Direct-Acting Oral Anticoagulants in Nonagenarians: A Call for More Data
Abstract The prevalence and embolic risk of atrial fibrillation (AF) increase with age. Vitamin K antagonists (VKAs) or direct-acting oral anticoagulants (DOACs) reduce the risk of stroke or embolism. The aim of this review was to summarize the paucity of information regarding the safety and efficacy of DOACs in AF patients aged 90 years or older. The maximum age of included patients is not listed in any of the available DOAC investigating trials and registries, thus it is unclear if nonagenarians were included. Additionally, we could not find any subgroup analysis addressing this issue. There is an urgent need t...
Source: Drugs and Aging - March 31, 2016 Category: Geriatrics Source Type: research

New oral anticoagulants for prophylaxis of stroke : Results of an expert conference on practical use in geriatric patients.
This article highlights the outcome of an expert meeting on the practical use of NOAC in elderly patients. An interdisciplinary group of experts discussed the current situation of stroke prevention in geriatric patients and its practical management in daily clinical practice. The topic was examined through focused impulse presentations and critical analyses as the basis for the expert consensus. The key issues are summarized in this paper. The European Society of Cardiology (ESC) guidelines from 2012 for the management of patients with non-valvular AF recommend NOAC as the preferred treatment and vitamin K antagonists (VKA...
Source: Zeitschrift fur Gerontologie und Geriatrie - February 10, 2016 Category: Geriatrics Authors: Bahrmann P, Harms F, Schambeck CM, Wehling M, Flohr J Tags: Z Gerontol Geriatr Source Type: research

Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial
Conclusions: older patients with AF are at particularly high risk of stroke if given aspirin and have substantially greater relative and absolute benefits from apixaban compared with younger patients with no greater risk of haemorrhage. Clinical Trial Registration: ClinicalTrials.gov number: NCT00496769. URL: https://clinicaltrials.gov/ct2/show/NCT00496769.
Source: Age and Ageing - January 13, 2016 Category: Geriatrics Authors: Ng, K. H., Shestakovska, O., Connolly, S. J., Eikelboom, J. W., Avezum, A., Diaz, R., Lanas, F., Yusuf, S., Hart, R. G. Tags: Research Papers Source Type: research

Stroke with atrial fibrillation or atrial flutter: a descriptive population-based study from the Brest stroke registry
The objective of the present prospective study, using data from 2008, was to evaluate the prevalence of AA (atrial fibrillation/flutter) in patients with stroke and the impact of implementing AF guidelines. Methods: The prevalence of AA was studied in patients diagnosed with stroke from January 1 to December 31, 2008 in the population-based Stroke Registry of Brest, France (total population, 363,760 according to the 2008 census, with 295,553 aged 15 years or older). Guidelines implementation was assessed in terms of antithrombotic therapy (VKA, antiplatelet agent, none), and the CHADS2 (Congestive heart failure, Hypertens...
Source: BMC Geriatrics - June 11, 2015 Category: Geriatrics Authors: Virginie JannouSerge TimsitEmmanuel NowakFrançois RouhartPhilippe GoasFrançois-Mathias MerrienIrina Viakhireva-DovganyukAnne Tirel-BadetsArmelle Gentric Source Type: research

Vitamin K Antagonists and Cognitive Impairment: Results From a Cross-Sectional Pilot Study Among Geriatric Patients
Conclusions. We found more frequent cognitive impairment associated with the use of VKAs, specifically fluindione, among geriatric patients.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 24, 2014 Category: Geriatrics Authors: Annweiler, C., Ferland, G., Barberger-Gateau, P., Brangier, A., Rolland, Y., Beauchet, O. Tags: Brief Report Source Type: research

Incidence, reversibility, risk factors and the protective effect of high body mass index against sarcopenia in community‐dwelling older Chinese adults
ConclusionSarcopenia incidence increases with age, but is potentially reversible in a Chinese elderly population. High body mass index is protective against sarcopenia incidence and its reversibility. Increasing physical activity and maintaining a healthy weight could be beneficial in the prevention of sarcopenia. Geriatr Gerontol Int 2014; 14 (Suppl. 1): 15–28.
Source: Geriatrics and Gerontology International - January 23, 2014 Category: Geriatrics Authors: Ruby Yu, Moses Wong, Jason Leung, Jenny Lee, Tung Wai Auyeung, Jean Woo Tags: ORIGINAL ARTICLE Source Type: research

Association Between Higher Plasma Lutein, Zeaxanthin, and Vitamin C Concentrations and Longer Telomere Length: Results of the Austrian Stroke Prevention Study
ConclusionThis study provides first evidence that higher lutein, zeaxanthin, and vitamin C concentrations in plasma are associated with longer LTL in normal elderly persons and suggest a protective role of these vitamins in telomere maintenance.
Source: Journal of the American Geriatrics Society - January 15, 2014 Category: Geriatrics Authors: Abhijit Sen, Gunther Marsche, Paul Freudenberger, Michael Schallert, Anna M. Toeglhofer, Christoph Nagl, Reinhold Schmidt, Lenore J. Launer, Helena Schmidt Tags: Clinical Investigations Source Type: research

The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial
Background: Homocysteine has been postulated as a novel, potentially reversible risk factor for osteoporosis and related fractures. We evaluated whether homocysteine-lowering therapy with B-vitamins in patients with symptomatic cerebrovascular disease reduced the incidence of osteoporotic fractures. Methods: VITAmins To Prevent Stroke (VITATOPS) was a prospective randomised double-blind placebo-controlled trial in which 8,164 patients with recent (within 7 months) stroke or transient ischemic attack were randomly allocated to double-blind treatment with one tablet daily of either placebo (n = 4,075) or B-vitamins (folic ac...
Source: BMC Geriatrics - September 3, 2013 Category: Geriatrics Authors: John GommansQilong YiJohn EikelboomGraeme HankeyChristopher ChenHelen Rodgers Source Type: research

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