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Interventions for treating urinary incontinence after stroke in adults.
CONCLUSIONS: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary inco...
Source: Cochrane Database of Systematic Reviews - February 1, 2019 Category: General Medicine Authors: Thomas LH, Coupe J, Cross LD, Tan AL, Watkins CL Tags: Cochrane Database Syst Rev Source Type: research

Development of rapid and effective risk prediction models for stroke in the Chinese population: a cross-sectional study
Conclusion The five machine learning models all had good predictive and discriminatory performance for stroke. The performance of RF and XGBoost was slightly better than that of LR, which was easier to interpret and less prone to overfitting. This work provides a rapid and accurate tool for stroke risk assessment, which can help to improve the efficiency of stroke screening medical services and the management of high-risk groups.
Source: BMJ Open - March 1, 2023 Category: General Medicine Authors: Qiu, Y., Cheng, S., Wu, Y., Yan, W., Hu, S., Chen, Y., Xu, Y., Chen, X., Yang, J., Chen, X., Zheng, H. Tags: Open access, Public health Source Type: research

Prevention of stroke: a global perspective
Publication date: 6–12 October 2018Source: The Lancet, Volume 392, Issue 10154Author(s): Jeyaraj D Pandian, Seana L Gall, Mahesh P Kate, Gisele S Silva, Rufus O Akinyemi, Bruce I Ovbiagele, Pablo M Lavados, Dorcas B C Gandhi, Amanda G ThriftSummaryAlong with the rising global burden of disability attributed to stroke, costs of stroke care are rising, providing the impetus to direct our research focus towards effective measures of stroke prevention. In this Series paper, we discuss strategies for reducing the risk of the emergence of disease (primordial prevention), preventing the onset of disease (primary prevention), an...
Source: The Lancet - October 5, 2018 Category: General Medicine Source Type: research

Protocol for the economic evaluation of the China Salt Substitute and Stroke Study (SSaSS)
This study protocol describes the planned within-trial economic evaluation of a low-sodium salt substitute intervention designed to reduce the risk of stroke in China. Methods and analyses The economic evaluation will be conducted alongside the Salt Substitute and Stroke Study: a 5-year large scale, cluster randomised controlled trial. The outcomes of interest are quality of life measured using the EuroQol-5-Dimensions and major adverse cardiovascular events. Costs will be estimated from a healthcare system perspective and will be sought from the routinely collected data available within the New Rural Cooperative Medical ...
Source: BMJ Open - July 20, 2021 Category: General Medicine Authors: Li, K.-C., Tian, M., Neal, B., Huang, L., Yu, J., Liu, Y., Yin, X., Zhang, X., Wu, Y., Li, N., Elliott, P., Yan, L., Labarthe, D., Hao, Z., Shi, J., Feng, X., Zhang, J., Zhang, Y., Zhang, R., Zhou, B., Li, Z., Sun, J., Zhao, Y., Yu, Y., Si, L., Lung, T. Tags: Open access, Health economics Source Type: research

Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

Salt Substitute Cut Disease and Death Rates in Large Trial
A randomized trial recently reported in the New England Journal of Medicine focused on an important question for older adults with high blood pressure or a previous stroke: Can switching from regular salt to a 75% sodium chloride and 25% potassium chloride substitute help protect against stroke, major cardiovascular events, or death?
Source: JAMA - October 26, 2021 Category: General Medicine Source Type: research

Health Tip: Eat Less Salt
-- Eating less salt could help you avoid heart disease or stroke. The U.S. Office on Women ' s Health suggests how to cut the amount of salt in your diet: Eat fewer processed foods. Check the sodium content on the product ' s nutrition facts label....
Source: Drugs.com - Daily MedNews - December 19, 2017 Category: General Medicine Source Type: news

UK ’s salt reduction deal with industry is linked to extra heart disease and stroke cases, research finds
Source: BMJ News - July 19, 2019 Category: General Medicine Source Type: research

Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial
Publication date: 24–30 August 2019Source: The Lancet, Volume 394, Issue 10199Author(s): Gholamreza Roshandel, Masoud Khoshnia, Hossein Poustchi, Karla Hemming, Farin Kamangar, Abdolsamad Gharavi, Mohammad Reza Ostovaneh, Alireza Nateghi, Masoud Majed, Behrooz Navabakhsh, Shahin Merat, Akram Pourshams, Mahdi Nalini, Fatemeh Malekzadeh, Masoumeh Sadeghi, Noushin Mohammadifard, Nizal Sarrafzadegan, Mohammad Naemi-Tabiei, Abdolreza Fazel, Paul BrennanSummaryBackgroundA fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovascular disease, especially in low-income ...
Source: The Lancet - August 23, 2019 Category: General Medicine Source Type: research

Screening strategies for hypertension.
CONCLUSIONS: There is an implicit assumption that early detection of hypertension through screening can reduce the burden of morbidity and mortality, but this assumption has not been tested in rigorous research studies. High-quality evidence from RCTs or programmatic evidence from NRCTs on the effectiveness and costs or harms of different screening strategies for hypertension (mass, targeted, or opportunistic) to reduce hypertension-related morbidity and mortality is lacking. PMID: 32378196 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - May 6, 2020 Category: General Medicine Authors: Schmidt BM, Durao S, Toews I, Bavuma CM, Hohlfeld A, Nury E, Meerpohl JJ, Kredo T Tags: Cochrane Database Syst Rev Source Type: research

AHA News: ' Angry and Depressed, ' Stroke Survivor Found Solace in Helping Others
FRIDAY, May 8, 2020 (American Heart Association News) -- Retired happily and resettled in a peaceful community near Salt Lake City, 70-year-old Doug Tapking is enjoying the good life– golfing and woodworking, singing in choirs with his wife,...
Source: Drugs.com - Daily MedNews - May 8, 2020 Category: General Medicine Source Type: news

8/10 --A Switch to Salt Substitute Could Slash Your Heart Risks
WEDNESDAY, Aug. 10, 2022 -- Swapping salt out for the salt substitute potassium chloride lowers blood pressure, and thereby the risk of heart attack, stroke and cardiovascular disease, a new analysis finds. " It ' s in processed and prepared foods...
Source: Drugs.com - Daily MedNews - August 8, 2022 Category: General Medicine Source Type: news

Multimorbidity of cardiometabolic diseases: a cross-sectional study of patterns, clusters and associated risk factors in sub-Saharan Africa
Conclusion Our findings show that cardiometabolic multimorbidity and lifestyle risk factors cluster in distinct patterns with a disproportionate burden among women, middle-aged, persons in high socioeconomic positions, and those with sedentary lifestyles and obesity. These results provide insights for health systems response in SSA to focus on these clusters as potential targets for integrated care.
Source: BMJ Open - February 9, 2023 Category: General Medicine Authors: Otieno, P., Asiki, G., Wekesah, F., Wilunda, C., Sanya, R. E., Wami, W., Agyemang, C. Tags: Open access, Cardiovascular medicine Source Type: research

WHO: Nations Must Do More to Reduce Salt Consumption by 2025
In 2013, 194 countries committed to a World Health Organization (WHO) goal of reducing global sodium intake, which in excess can increase people ’s risk of heart disease, stroke, and premature death, by 30% by 2025. A report published by the WHO, however, showed that the world is not on track to meet that target.
Source: JAMA - Journal of the American Medical Association - March 22, 2023 Category: General Medicine Source Type: research