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Genes, Vol. 12, Pages 1537: Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients
Kazuyuki Nagatsuka The genotypes of vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) can influence therapeutic warfarin doses. Conversely, nongenetic factors, especially renal function, are associated with warfarin maintenance doses; however, the optimal algorithm for considering genes and renal dysfunction has not been established. This single-center prospective cohort study aimed to evaluate the factors affecting warfarin maintenance doses and develop pharmacogenetics-guided algorithms, including the factors of renal impairment and others. To commence, 176 outpatients who were prescrib...
Source: Genes - September 28, 2021 Category: Genetics & Stem Cells Authors: Tomotaka Tanaka Masafumi Ihara Kazuki Fukuma Haruko Yamamoto Kazuo Washida Shunsuke Kimura Akiko Kada Shigeki Miyata Toshiyuki Miyata Kazuyuki Nagatsuka Tags: Article Source Type: research

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in < i > Caenorhabditis elegans < /i >
by Rachele Sangaletti, Massimo D ’Amico, Jeff Grant, David Della-Morte, Laura Bianchi Sirtuins are NAD⁺-dependent deacetylases, lipoamidases, and ADP-ribosyltransferases that link cellular metabolism to multiple intracellular pathways that influence processes as diverse as cell survival, longevity, and cancer growth. Sirtuins influence the extent of neuronal death in stroke. Howe ver, different sirtuins appear to have opposite roles in neuronal protection. InCaenorhabditis elegans, we found that knock-out of mitochondrial sirtuinsir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hypera...
Source: PLoS Genetics - August 18, 2017 Category: Genetics & Stem Cells Authors: Rachele Sangaletti Source Type: research

GSE94661 Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions
Contributors : Brittany G Durgin ; Olga A Cherepanova ; Delphine Gomez ; Themistoclis Karaoli ; Gabriel F Alencar ; Joshua T Butcher ; Yuging Zhou ; Michelle P Bendeck ; Brant E Isakson ; Gary K Owens ; Jessic J ConnelySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerotic plaque rupture with subsequent embolic events is a major cause of sudden death from myocardial infarction or stroke. Although smooth muscle cells (SMC) produce and respond to collagens in vitro, there is no direct evidence in vivo that SMC are a critical source of collagens impacting lesion development or f...
Source: GEO: Gene Expression Omnibus - September 8, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE72278 A novel lineage of adipose tissue regulatory T cells controls obesity and insulin resistance
Contributors : Emilie Stolarczyk ; Charlotte Bailey ; Natividad Garrido-Mesa ; Paul Lavender ; Richard Jenner ; Graham Lord ; Jane HowardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe epidemic of obesity and its associated systemic metabolic complications continues to increase. Adipose tissue (AT)-associated T cells have been proposed to play an important role in the regulation of bodyweight and insulin sensitivity with a link to Th1 or Th2 lineage specification. A specific subset of regulatory T cells (TREGS) plays a critical and non-redundant role in controlling s...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

This Month in The Journal
Elevated blood pressure is a well-recognized risk factor for conditions such as heart disease, heart failure, and stroke. Blood pressure, in turn, is influenced by several factors, both genetic and non-genetic. However, there is a lack of understanding regarding the potential for lifestyle (e.g., choices related to smoking, alcohol consumption, diet, and exercise) to modulate how genetic variation influences blood pressure. To gain insight into this issue, Sung et  al. incorporated smoking status into a genome-wide meta-analysis of systolic and diastolic blood pressure in over 600,000 individuals spanning multiple ancestries.
Source: The American Journal of Human Genetics - March 1, 2018 Category: Genetics & Stem Cells Authors: Sarah Ratzel, Sara B. Cullinan Tags: Editors' Corner Source Type: research

Association of rs6921438 A < G with serum vascular endothelial growth factor concentrations in patients with metabolic syndrome.
CONCLUSION: Our findings show an association between a VEGF gene polymorphism with serum VEGF concentrations and dietary fat intake, but there was no association with the presence of MetS. PMID: 29733969 [PubMed - as supplied by publisher]
Source: Gene - May 4, 2018 Category: Genetics & Stem Cells Authors: Ghazizadeh H, Avan A, Fazilati M, Azimi-Nezhad M, Tayefi M, Ghasemi F, Mehramiz M, Moohebati M, Ebrahimi M, Mirhafez SR, Ferns GA, Esmaeili H, Pasdar A, Ghayour-Mobarhan M Tags: Gene Source Type: research

Genes, Vol. 13, Pages 510: Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice
Weibin Shi Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. Apoe-null (Apoe&amp;minus;/&amp;minus;) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ Apoe&amp;minus;/&amp;minus; mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyp...
Source: Genes - March 14, 2022 Category: Genetics & Stem Cells Authors: Lisa J. Shi Bilhan Chagari Alexander An Mei-Hua Chen Yongde Bao Weibin Shi Tags: Article Source Type: research