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Specialty: Drugs & Pharmacology
Nutrition: Calcium

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Total 116 results found since Jan 2013.

Clevidipine: A Review of Its Use for Managing Blood Pressure in Perioperative and Intensive Care Settings
In conclusion, intravenous clevidipine is a valuable agent for the management of BP in perioperative and intensive care settings.
Source: Drugs - October 14, 2014 Category: Drugs & Pharmacology Source Type: research

Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo.
In this study, we investigated the neuroprotective and neurorescue effects of TBN on various in vitro and in vivo models of PD and explored its possible mechanisms of action. The results show that TBN exerted significant neuroprotection on 1-methyl-4-phenylpyridinium (MPP(+))-induced damage in SH-SY5Y cells and primary dopaminergic neurons, as well as on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neuron loss in zebrafish (TBN and MPTP were added simultaneously into the fish embryo medium and the treatment period was 48 h). In the MPTP-induced mouse and 6-hydroxydopamine (6-OHDA)-induced rat ...
Source: Biological and Pharmaceutical Bulletin - October 5, 2014 Category: Drugs & Pharmacology Authors: Guo B, Xu D, Duan H, Du J, Zhang Z, Lee SM, Wang Y Tags: Biol Pharm Bull Source Type: research

Comparative Persistence on β-Blockers Versus Calcium Channel Blockers for Ventricular Rate Control in Nonelderly Patients With Atrial Fibrillation.
CONCLUSIONS: Evidence suggests that nonelderly AF patients, when prescribed rate-control therapy, persist longer on BBs than CCBs. Because this is the first long-term study comparing the 2 drug classes in the nonelderly population, further research is suggested. PMID: 25280975 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - October 3, 2014 Category: Drugs & Pharmacology Authors: Desai VC, Kelton CM, Metzger AH, Cavanaugh TM, Guo JJ, Heaton PC Tags: Ann Pharmacother Source Type: research

1,8‐Cineole ameliorates oxygen‐glucose deprivation/reoxygenation‐induced ischaemic injury by reducing oxidative stress in rat cortical neuron/glia
ConclusionCollectively, these results suggest 1,8‐cineole as a potentially effective neuroprotective and anti‐oxidative candidate for the treatment of patients with ischaemic stroke.
Source: Journal of Pharmacy and Pharmacology - August 3, 2014 Category: Drugs & Pharmacology Authors: Sangwoo Ryu, Hyeon Park, Geun Hee Seol, In‐Young Choi Tags: Research Paper Source Type: research

Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation
Conclusion and ImplicationsC1 behaved as a promising multifunctional small molecule targeting a number of key pathways involved in AF.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason RB Dyck, Peter E Tags: RESEARCH PAPER Source Type: research

Novel Analogues of Chlormethiazole are Neuroprotective in Four Cellular Models of Neurodegeneration by a Mechanism with Variable Dependence on GABAA Receptor Potentiation
Conclusions and ImplicationsThe results support the concept that CMZ does not contain a single pharmacophore, rather that broad‐spectrum neuroprotection results from a GABAA‐dependent mechanism represented by GN‐28, combined with a mechanism represented in GN‐38 that shows the least dependence on GABAA receptors. These findings allow further refinement of the neuroprotective pharmacophore and investigation into secondary mechanisms that will assist in identifying methiazole‐based compounds of use in treating neurodegeneration.
Source: British Journal of Pharmacology - October 10, 2013 Category: Drugs & Pharmacology Authors: Lawren VandeVrede, Ehsan Tavassoli, Jia Luo, Zhihui Qin, Lan Yue, David R. Pepperberg, Gregory R. Thatcher Tags: Research Paper Source Type: research

Myogenic Tone as a Therapeutic Target for Ischemic Stroke.
Abstract Ischemic stroke causes vascular paralysis and impaired autoregulation in the brain, the degree of which is dependent on the depth and duration of ischemia and reperfusion (I/R). Ischemic stroke also impairs myogenic response of middle cerebral arteries (MCA) that may be an underlying mechanism by which autoregulation is impaired. Myogenic responses are affected by I/R through several mechanisms, including production of peroxynitrite, depolymerization of F-actin in vascular smooth muscle, and circulating vasoactive factors. The vascular endothelium is also significantly affected during focal ischemia that ...
Source: Current Vascular Pharmacology - September 25, 2013 Category: Drugs & Pharmacology Authors: Palomares SM, Cipolla MJ Tags: Curr Vasc Pharmacol Source Type: research

Characterization of a novel multi‐functional resveratrol derivative for the treatment of atrial fibrillation.
Conclusion and ImplicationsThese findings indicate that C1 is a promising multi‐functional small molecule that targets a number of key pathways involved in AF.
Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason R. Dyck, Peter E. Tags: Research Paper Source Type: research

Influence of calcium supplements on the occurrence of cardiovascular events.
CONCLUSION: The results of studies on the influence of calcium supplements on the cardiovascular system have been varied. Overall, the benefits of calcium supplementation, including the positive effects on bone health, appear to outweigh the theoretical risk of increased cardiovascular events. PMID: 23784160 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - June 21, 2013 Category: Drugs & Pharmacology Authors: Downing L, Islam MA Tags: Am J Health Syst Pharm Source Type: research

P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.
Abstract Brain-resident microglia may promote tissue repair following stroke but, like other cells, they are vulnerable to ischemia. Here we identify mechanisms involved in microglial ischemic vulnerability. Using time-lapse imaging of cultured BV2 microglia, we show that simulated ischemia (oxygen-glucose deprivation; OGD) induces BV2 microglial cell death. Removal of extracellular Ca(2+) or application of Brilliant Blue G (BBG), a potent P2X7 receptor (P2X7R) antagonist, protected BV2 microglia from death. To validate and extend these in vitro findings, we assessed parenchymal microglia in freshly isolated hipp...
Source: Neuropharmacology - June 12, 2013 Category: Drugs & Pharmacology Authors: Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME Tags: Neuropharmacology Source Type: research

Cohort study: Long term calcium intake and rates of all cause and cardiovascular mortality
Source: BMJ Area: News Supplementation with calcium has become increasingly common but recent analyses of trials have suggested a higher risk of both ischemic heart disease and stroke with calcium supplements in women. To investigate the association between long term dietary and supplemental intake of calcium with all cause mortality as well as with cardiovascular mortality, researchers conducted a prospective longitudinal cohort study in Swedish women.   The Swedish mammography cohort, established in 1987-90, provided the data for the purposes of this study. Women were born between 1914 and 1948 and followed-up ...
Source: NeLM - News - February 13, 2013 Category: Drugs & Pharmacology Source Type: news