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CO33 Methodological Challenges and Considerations for Decision Makers When Assessing within-Class Comparative Effectiveness and Cost-Effectiveness: The Case of Non-Vitamin K Antagonist Oral Anticoagulants
The United Kingdom National Institute of Health Care Excellence (NICE) published a draft clinical guideline for consultation on anticoagulation therapy for stroke prevention in individuals with atrial fibrillation in September 2020 that addressed which non-vitamin K antagonist oral anticoagulant (NOAC) therapy (apixaban, dabigatran, rivaroxaban, edoxaban) is most clinically and cost-effective. We aimed to elucidate methodological considerations and challenges involved in evaluating the comparative effectiveness and cost-effectiveness of within-class treatments for the  purpose of decision making by a reimbursement authority.
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: A Briggs, A Howarth, S Davies, J Schneider, G Spentzouris, F Mughal, A Fuat, M Fay Source Type: research

Embolic MCA Stroke Treated With tPA and TICI-3 Mechanical Thrombectomy Complicated by Hemiballismus: A Case Study and Literature Review
This report examines the etiology of hemiballistic movements that began 24 hours after a 63-year-old male with vascular risk factors received tissue plasminogen activator (tPa) and thrombolysis in cerebral ischemia 3 (TICI3) thrombectomy for a left middle cerebral artery (MCA) ischemic stroke. The clinical course was reviewed from an admission at a large academic institution where assessments included physical exams, head and neck computed tomography angiography (CTA), and head magnetic resonance imaging (MRI) without contrast. The patient's initial physical exam was consistent with a left MCA syndrome and included a Natio...
Source: Military Medicine - November 10, 2021 Category: International Medicine & Public Health Authors: Peter S Tatum Joshua Kornbluth Andrew Soroka Source Type: research

Brain injury lab receives additional federal funding to boost research
(University of California - Riverside) Earlier this year, Viji Santhakumar, an associate professor of molecular, cell and systems biology at UC Riverside, received funding from the National Institute of Neurological Disaster and Stroke of the National Institutes of Health, or NIH, to further pursue research on moderate concussive brain injury. Now three scientists in her lab have received federal funding -- no small achievement for a university research group.
Source: EurekAlert! - Medicine and Health - July 12, 2021 Category: International Medicine & Public Health Source Type: news

CWRU researcher secures $1.2M to develop MS diagnostic tests
(Case Western Reserve University) Case Western Reserve University researcher Farren Briggs was awarded $1.2 million over three years from the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health to identify biomarkers to improve the diagnoses of multiple sclerosis (MS), including the ability to monitor disease activity and progression.
Source: EurekAlert! - Medicine and Health - June 10, 2021 Category: International Medicine & Public Health Source Type: news

Study shows how taking short breaks may help our brains learn new skills
(NIH/National Institute of Neurological Disorders and Stroke) In a study of healthy volunteers, National Institutes of Health researchers have mapped out the brain activity that flows when we learn a new skill, such as playing a new song on the piano, and discovered why taking short breaks from practice is a key to learning.
Source: EurekAlert! - Medicine and Health - June 8, 2021 Category: International Medicine & Public Health Source Type: news

Scientists discover a new genetic form of ALS in children
(NIH/National Institute of Neurological Disorders and Stroke) In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University (USU) discovered a new and unique form of amyotrophic lateral sclerosis (ALS). Unlike most cases of ALS, the disease began attacking these patients during childhood, worsened more slowly than usual, and was linked to a gene, called SPTLC1, that is part of the body's fat production system.
Source: EurekAlert! - Medicine and Health - May 31, 2021 Category: International Medicine & Public Health Source Type: news

NIH awards $4.7m to Kennedy Krieger Institute researcher for movement learning study
(PROFILES, Inc.) The National Institutes of Health (NIH) recently awarded Amy Bastian, Ph.D., PT, chief science officer and director of the Motion Analysis Lab at Kennedy Krieger Institute, with an eight-year, $4.7 million National Institute of Neurological Disorders and Stroke (NINDS) Research Program Award (N35) to support a study examining movement learning mechanisms and how this process is affected by brain damage.
Source: EurekAlert! - Medicine and Health - May 25, 2021 Category: International Medicine & Public Health Source Type: news

Temple scientists poised to gain insight into underpinnings of Alzheimer's thanks to grant
(Temple University Health System) Thanks to a new three-year, $2.27 million grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke, Dr. John Elrod and colleagues are poised to gain novel insight into biological mechanisms that may be driving or worsening neurodegeneration. The researchers will investigate potential mechanisms using mouse models of Alzheimer's disease and a systems biology approach. The work could help identify new drug targets and therapeutic opportunities for Alzheimer's disease.
Source: EurekAlert! - Social and Behavioral Science - May 11, 2021 Category: International Medicine & Public Health Source Type: news

Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases
(NIH/National Institute of Neurological Disorders and Stroke) In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies. The results also supported the disorder's ties to Parkinson's and Alzheimer diseases.
Source: EurekAlert! - Medicine and Health - February 16, 2021 Category: International Medicine & Public Health Source Type: news

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