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Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study
EBioMedicine. 2022 Aug 2;83:104189. doi: 10.1016/j.ebiom.2022.104189. Online ahead of print.ABSTRACTBACKGROUND: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and part of an active pool. To address the limited information about EETs and CVD in humans, we conducted a prospective study of total plasma EETs (free + esterified) and diabetes-related CVD in the Cardiovascular Health Study (CHS).METHODS: We measured 4 EET species and their metabolites, dih...
Source: Atherosclerosis - August 5, 2022 Category: Cardiology Authors: Rozenn N Lemaitre Paul N Jensen Maxwell Zeigler Amanda M Fretts Jason G Umans Barbara V Howard Colleen M Sitlani Barbara McKnight Sina A Gharib Irena B King David S Siscovick Bruce M Psaty Nona Sotoodehnia Rheem A Totah Source Type: research

Methods for stroke severity assessment by chart review in the Atherosclerosis Risk in Communities study
Sci Rep. 2022 Jul 19;12(1):12338. doi: 10.1038/s41598-022-16522-7.ABSTRACTStroke severity is the most important predictor of post-stroke outcome. Most longitudinal cohort studies do not include direct and validated measures of stroke severity, yet these indicators may provide valuable information about post-stroke outcomes, as well as risk factor associations. In the Atherosclerosis Risk in Communities (ARIC) study, stroke severity data were retrospectively collected, and this paper outlines the procedures used and shares them as a model for assessment of stroke severity in other large epidemiologic studies. Trained physic...
Source: Atherosclerosis - July 19, 2022 Category: Cardiology Authors: Silvia Koton Shalom Patole Julia M Carlson Taylor Haight Michelle Johansen Andrea L C Schneider James Russell Pike Rebecca F Gottesman Josef Coresh Source Type: research

Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke
This study aimed to explore the potential value of circRNAs for identifying acute neurological deterioration and estimating long-term survival for acute ischemic stroke (AIS). One hundred healthy controls and 200 patients with AIS within 72 h were recruited, 140 of whom were admitted within 24 h after onset. CircRNA levels in peripheral blood were measured by quantitative polymerase chain reaction (qPCR). Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembol...
Source: Atherosclerosis - June 20, 2022 Category: Cardiology Authors: Juan Zu Lei Zuo Lin Zhang Zan Wang Yachen Shi Lihua Gu Zhijun Zhang Source Type: research

Circulating Exosomal miRNAs as Novel Biomarkers Perform Superior Diagnostic Efficiency Compared With Plasma miRNAs for Large-Artery Atherosclerosis Stroke
Front Pharmacol. 2021 Nov 26;12:791644. doi: 10.3389/fphar.2021.791644. eCollection 2021.ABSTRACTRecently, exosomal miRNAs have been reported to be associated with some diseases, and these miRNAs can be used for diagnosis and treatment. However, diagnostic biomarkers of exosomal miRNAs for ischemic stroke have rarely been studied. In the present study, we aimed to identify exosomal miRNAs that are associated with large-artery atherosclerosis (LAA) stroke, the most common subtype of ischemic stroke; to further verify their diagnostic efficiency; and to obtain promising biomarkers. High-throughput sequencing was performed on...
Source: Atherosclerosis - December 13, 2021 Category: Cardiology Authors: Mengying Niu Hong Li Xu Li Xiaoqian Yan Aijun Ma Xudong Pan Xiaoyan Zhu Source Type: research

Assessing the Efficacy and Safety of Tirofiban in Combination With Dual-antiplatelet Therapy in Progressive Ischemic Stroke Patients
This study assessed the efficacy and safety of tirofiban in combination with dual-antiplatelet therapy (DAPT) in progressive ischemic stroke. One hundred and four patients equally divided into a tirofiban group or DAPT group were enrolled from June 2018 to December 2019. Efficacy outcomes included National Institutes of Health Stroke Scale score for 14 days, and modified Rankin scale (mRs) scores as excellent (mRs 0–1) or favorable (mRs 0–2) measured 90 days after stroke. At 14 days, the tirofiban group had a lower National Institutes of Health Stroke Scale score compared with the DAPT group (F = 14.959, P = 0.000). Th...
Source: Journal of Cardiovascular Pharmacology - September 1, 2021 Category: Cardiology Tags: Original Article Source Type: research

Association of High Blood Homocysteine and Risk of Increased Severity of Ischemic Stroke Events
Int J Angiol DOI: 10.1055/s-0038-1667141Stroke is the leading cause of death and disability in the world as well as in Indonesia. Initial stroke severity is an important factor that affects short- and long-term stroke outcomes. This cross-sectional study was conducted in Cipto Mangunkusumo Hospital from July 2017 to January 2018 to investigate the factors that affect stroke severity. A total of 77 acute ischemic stroke patients were divided into three groups, which include low blood homocysteine levels (< 9 μmol/L), moderate blood homocysteine levels (9–15 μmol/L), and high blood homocysteine levels (> 15 μmol/L...
Source: International Journal of Angiology - July 26, 2018 Category: Cardiology Authors: Harris, Salim Rasyid, Al Kurniawan, Mohammad Mesiano, Taufik Hidayat, Rakhmad Tags: Original Article Source Type: research

Heartfelt sepsis: microvascular injury due to genomic storm.
Abstract Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulnerable patients, with these groups suffering from the highest sepsis mortality. In both groups, many survivors respectively display serious developmental disabilities and cognitive decline. The National Institute of Health National Heart Lung and Blood Institute Panel redefined sepsis as a "severe endothelial dysfunction syndrome in response to intravascular and...
Source: Polish Heart Journal - July 5, 2018 Category: Cardiology Authors: Hawiger J Tags: Kardiol Pol Source Type: research

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association AHA Scientific Statement
The completion of the Human Genome Project has unleashed a wealth of human genomics information, but it remains unclear how best to implement this information for the benefit of patients. The standard approach of biomedical research, with researchers pursuing advances in knowledge in the laboratory and, separately, clinicians translating research findings into the clinic as much as decades later, will need to give way to new interdisciplinary models for research in genomic medicine. These models should include scientists and clinicians actively working as teams to study patients and populations recruited in clinical settin...
Source: Circulation: Cardiovascular Genetics - May 29, 2018 Category: Cardiology Authors: Musunuru, K., Arora, P., Cooke, J. P., Ferguson, J. F., Hershberger, R. E., Hickey, K. T., Lee, J.-M., Lima, J. A. C., Loscalzo, J., Pereira, N. L., Russell, M. W., Shah, S. H., Sheikh, F., Wang, T. J., MacRae, C. A., On behalf of the American Heart Assoc Tags: Statements and Guidelines AHA Scientific Statement Source Type: research

The dispersion of myocardial repolarization in ischemic stroke and intracranial hemorrhage
Markers of dispersion of myocardial repolarization have been proposed to identify the patients at higher risk of malignant arrhythmic events. The aim of the present study is to assess a possible association of the electrocardiografic (ECG) markers of the dispersion of repolarization with the type of stroke, involvement of insula, neurological severity (National Institutes of Health Stroke Scale, NIHSS score), and disability (modified Rankin Scale, mRS score) in patients with a cerebrovascular event.
Source: Journal of Electrocardiology - May 17, 2018 Category: Cardiology Authors: Alessandra Danese, Manuel Cappellari, Elia Pancheri, Giacomo Mugnai, Nicola Micheletti, Giampaolo Tomelleri, Monica Carletti, Giulia Turri, Vincenzo Marafioti, Salvatore Monaco, Bruno Bonetti, Paolo Bovi Source Type: research

The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: The SOS-Stroke Study
Oxidized low-density lipoprotein (oxLDL) has a defined role in the genesis and development of atherosclerosis, however, whether it is related to severity of neurological deficits is rarely reported. The aim of our study was to investigate the potential association between oxLDL and the National Institutes of Health Stroke Scale (NIHSS) score among patients with acute ischemic stroke.
Source: Atherosclerosis - January 21, 2018 Category: Cardiology Authors: Anxin Wang, Ying Cui, Xia Meng, Zhaoping Su, Yibin Cao, Yuling Yang, Changcheng Liu, Liye Dai, Youxin Wang, Yilong Wang Source Type: research

115 Anticoagulation in atrial fibrillation – a single-centre audit on patient education, stroke and bleeding risk assessments and use of direct oral anticoagulants (DOACs)
Objective: To assess adherence to the National Institute of Health and Care Excellence (NICE) guidelines on management of atrial fibrillation in adults, specifically the provision of a personalised package of care and information to patients, and stroke and bleeding risk assessments. To assess the frequency of use of DOACs as the anticoagulant of choice.
Source: Europace - October 5, 2017 Category: Cardiology Source Type: research

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
Sex differences between women and men are often overlooked and underappreciated when studying the cardiovascular system. It has been long assumed that men and women are physiologically similar, and this notion has resulted in women being clinically evaluated and treated for cardiovascular pathophysiological complications as men. Currently, there is increased recognition of fundamental sex differences in cardiovascular function, anatomy, cell signaling, and pathophysiology. The National Institutes of Health have enacted guidelines expressly to gain knowledge about ways the sexes differ in both normal function and diseases a...
Source: AJP: Heart and Circulatory Physiology - September 5, 2017 Category: Cardiology Authors: Boese, A. C., Kim, S. C., Yin, K.-J., Lee, J.-P., Hamblin, M. H. Tags: REVIEW Source Type: research

Assessment of clinical severity in patients with infective endocarditis with cardio-embolic strokes
We sincerely thank Biteker et al. for their interest in our study to suggest a possible association of stroke severity with clinical outcomes in patients with infective endocarditis (IE) with cerebral complications regardless of whether early surgery or conventional treatment. They recommended us to use National Institutes of Health Stroke Scale (NIHSS) score to evaluate this issue as recently reported by Murai et al. [1], while a necessity of patient's answer to several inquiries for a measurement of NIHSS score had imposed major limitations on analyzing our data retrospectively.
Source: International Journal of Cardiology - March 10, 2017 Category: Cardiology Authors: Makoto Suzuki, Shuichiro Takanashi Tags: Correspondence Source Type: research

Prestroke treatment with beta-blockers for hypertension is not associated with severity and poor outcome in patients with ischemic stroke: data from a national stroke registry
Background: Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypertensive patients hospitalized with acute ischemic stroke. Methods: All 3915 patients with ischemic stroke, treated prestroke for hypertension and registered in the National Acute Stroke ISraeli, were included. Treatment for hypertension was classified by medication type (beta-blockers, diuretics, calcium ant...
Source: Journal of Hypertension - March 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

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