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Therapy: Neoadjuvant Therapy
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Total 159 results found since Jan 2013.
Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial)
BMJ Open. 2023 Sep 12;13(9):e069499. doi: 10.1136/bmjopen-2022-069499.ABSTRACTINTRODUCTION: Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant survival benefit in lung cancer. In locally advanced rectal cancer (LARC), neoadjuvant radiotherapy plus immune checkpoint inhibitors have also achieved surprisingly high pathological complete response (pCR) rates even in proficient mismatch-repair patients. As existing researches are all phase 2, single-cohort trials, we aim to conduct a randomised, controlled trial to further clar...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Kai Pang Yun Yang Dan Tian Na Zeng Shun Cao Shen Ling Jiale Gao Pengfei Zhao Hao Wang Yuanyuan Kong Jie Zhang Guangyong Chen Wei Deng Zhigang Bai Lan Jin Guoju Wu Danyang Zhu Yue Wang Jiaolin Zhou Bin Wu Guole Lin Yi Xiao Zhidong Gao Yingjiang Ye Xin Wang Source Type: research
Axillary lymph node dissection versus radiotherapy in breast cancer with positive sentinel nodes after neoadjuvant therapy (ADARNAT trial)
This study will assess whether ART is non-inferior to ALND in terms of recurrence and overall survival in patients with positive SLN after NST, including whether it reduces surgery-related adverse effects.METHODS AND ANALYSES: This multicenter, randomized, open-label, phase 3 trial will enroll 1660 patients with breast cancer and positive SLNs following NST in approximately 50 Spanish centers over 3 years. Patients will be stratified by NST regimen and nodal involvement (isolated tumoral cells or micrometastasis versus macrometastasis) and randomly assigned 1:1 to ART without ALND (study arm) or ALND alone (control arm). L...
Source: Cancer Control - August 25, 2023 Category: Cancer & Oncology Authors: Amparo Garcia-Tejedor Carlos Ortega-Exposito Sira Salinas Ana Luzardo-Gonz ález Catalina Falo Evelyn Martinez-P érez H éctor Pérez-Montero M Teresa Soler-Mons ó Maria-Teresa Bajen Ana Benitez Raul Ortega Anna Petit Anna Guma Miriam Campos Maria J Pl Source Type: research
Clinical significance of regulatory T cells and T lymphocyte subsets in peripheral blood in neoadjuvant chemotherapy for breast cancer
Am J Cancer Res. 2023 Jul 15;13(7):3091-3099. eCollection 2023.ABSTRACTThe impact of the immune response on the therapeutical efficacy of neoadjuvant chemotherapy for breast cancer remains largely unknown. To characterize the role of regulatory T cells (CD4+CD25+CD127lowTreg), T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) and NK cells in neoadjuvant chemotherapy, we investigated the correlation patterns of these immune cell subsets with the progression of breast cancer. A total of 120 breast cancer patients receiving neoadjuvant chemotherapy in Nanjing Maternal and Child Health Hospital from May 2019 to November 2021 were r...
Source: Cell Research - August 10, 2023 Category: Cytology Authors: Xiao-Dong Mao Su-Zhu Chen Su-Qing Shen Kang-Sheng Liu Source Type: research
Local Excision Versus Total Mesorectal Excision After Favourable Response to Neoadjuvant Therapy in Low Rectal Cancer: a Multi-centre Experience
This study is a prospective comparative phase III study, where 46 rectal cancer patients were recruited from patients attending Oncology Centre of Mansoura University and Queen Alexandra Hospital Portsmouth University Hospital NHS with a median follow-up 36 months. The two recruited groups were as follows: group (A), 18 patients who underwent conventional radical surgery by TME; and group (B), 28 patients who underwent trans-anal endoscopic local excision. Patients of resectable low rectal cancer (below 10 cms from anal verge) with sphincter saving procedures were included: cT1-T3N0. The median operative time for LE was 12...
Source: Cancer Control - June 16, 2023 Category: Cancer & Oncology Authors: Ahmed M Fareed Osama Eldamshety Fayz Shahatto Ashraf Khater Sherif Z Kotb Islam A Elzahaby Jim S Khan Source Type: research
A Prehabilitation Program in Patients with Breast Cancer Receiving Neoadjuvant Therapy to Minimize Musculoskeletal Postoperative Complications and Enhance Recovery (PREOPtimize): A Protocol for a Randomized Controlled Trial
Phys Ther. 2023 Jun 15:pzad062. doi: 10.1093/ptj/pzad062. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study is to assess the effects of a prehabilitation program (PREOPtimize), consisting of Nordic Walking and resistance training exercises plus health education in patients with breast cancer who are receiving neoadjuvant therapy to enhance postoperative functionality of the affected arm. A secondary aim will be to compare the short-term effects of the intervention on other patient-reported outcome measures.METHODS: This will be an assessor-blind, randomized controlled trial with a parallel group design conduct...
Source: Health Physics - June 15, 2023 Category: Physics Authors: Anabel Casanovas- Álvarez Raquel Sebio-Garc ía Magda Ciendones Jordi Cuartero Blanca Estanyol Josep Padr ós B árbara García-Valdecasas Agust í Barnadas Jaume Masi à Source Type: research
Comprehensive diagnosis and treatment of ductal carcinoma of the submandibular gland: case report and literature review
We report a rare case of SDC of the submandibular gland. A 62-year-old man presented to our hospital with complaints of swelling in the right submaxillary area for 4 months, rapidly growing, with pain for 10 days. After admission, fine needle aspiration (FNA) revealed right submandibular gland ductal carcinoma. Considering its aggressiveness, large size, and invasion of parapharyngeal and oral floor soft tissues, the patient received two cycles of neoadjuvant chemotherapy followed by extended surgical resection. Postoperatively, the patient received four cycles of concurrent chemoradiotherapy, followed by afatinib targeted...
Source: International Journal of Clinical and Experimental Pathology - April 10, 2023 Category: Pathology Authors: Feng Liu Li Fan Lifang Lu Hongyi Guo Jie Nan Fei Han Source Type: research
