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Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
Euro Surveill. 2023 Sep;28(38). doi: 10.2807/1560-7917.ES.2023.28.38.2300171.ABSTRACTOn 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts an...
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Berta Grau-Pujol Jo ão Vieira Martins Isabel Goncalves Fernanda Rodrigues Rita de Sousa Dina Oliveira Joana Bettencourt Diana Mendes In ês Mateus de Cunha Sara Pocinho Ana Firme Benvinda Estela Dos Santos Andr é Peralta Santos Maria Jo ão Albuquerque Source Type: research

Adeno-Associated Virus 2 and Human Adenovirus F41 in Wastewater during Outbreak of Severe Acute Hepatitis in Children, Ireland
Emerg Infect Dis. 2023 Apr;29(4):751-760. doi: 10.3201/eid2904.221878.ABSTRACTDuring April-July 2022, outbreaks of severe acute hepatitis of unknown etiology (SAHUE) were reported in 35 countries. Five percent of cases required liver transplantation, and 22 patients died. Viral metagenomic studies of clinical samples from SAHUE cases showed a correlation with human adenovirus F type 41 (HAdV-F41) and adeno-associated virus type 2 (AAV2). To explore the association between those DNA viruses and SAHUE in children in Ireland, we quantified HAdV-F41 and AAV2 in samples collected from a wastewater treatment plant serving 40% of...
Source: Emerging Infectious Diseases - March 23, 2023 Category: Infectious Diseases Authors: Niamh A Martin Gabriel Gonzalez Liam J Reynolds Charlene Bennett Christine Campbell Tristan M Nolan Alannah Byrne Sanne Fennema Niamh Holohan Sailusha Ratnam Kuntamukkula Natasha Sarwar Laura Sala-Comorera Jonathan Dean Jose Maria Urtasun-Elizari Daniel H Source Type: research

Dengue Transmission From Donor to Recipient After Deceased Donor Liver Transplant; Report of a Case and Review of Literature: Is Liver a Privileged Organ?
We report a probable case of dengue virus transmission via deceased donorlivertransplant. The donor was asymptomatic for dengue infection, and the liver recipient developed fever and thrombocytopenia 8 days after transplant. The recipient's testresults were positive forthe antigen for nonstructural protein 1 and for immunoglobulin M; however, donor serum samples were not available. Other transplant recipients (renal allograft) also showed dengue-positive test results during the same period, and these patients eventually died. Dengue illness in the liver recipient was severe and associated with shock and cardiomyopathy that...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 21, 2022 Category: Transplant Surgery Authors: Divij Jayant Arunanshu Behera Lileswar Kaman Ajay Savlania Cherring Tandup Krishna Naik Source Type: research

Hepatitis of unknown etiology in children in Brazil: A new challenge or the usual scenario ?
CONCLUSIONS: A non-negligible number of hospitalizations due to hepatitis with unknown etiology in children/adolescents was observed in the last years in Brazil. Up to 15% of those cases needed liver transplantation or died.PMID:36356642 | DOI:10.1016/j.bjid.2022.102715
Source: Braz J Infect Dis - November 10, 2022 Category: Infectious Diseases Authors: Rodolfo Castro Marcelo Ribeiro-Alves Valdilea G Veloso Hugo Perazzo Source Type: research

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