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Viral vectors engineered for gene therapy
Int Rev Cell Mol Biol. 2023;379:1-41. doi: 10.1016/bs.ircmb.2023.05.005. Epub 2023 Jul 1.ABSTRACTGene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rh...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Kenneth Lundstrom Source Type: research

Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine
Mol Ther Methods Clin Dev. 2023 Jun 27;30:194-207. doi: 10.1016/j.omtm.2023.06.009. eCollection 2023 Sep 14.ABSTRACTBecause of continual generation of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to design the next generation of vaccines to combat the threat posed by SARS-CoV-2 variants. We developed human adenovirus (HAd) vector-based vaccines (HAd-Spike/C5 and HAd-Spike) that express the whole Spike (S) protein of SARS-CoV-2 with or without autophagy-inducing peptide C5 (AIP-C5), respectively. Mice or golden Syrian hamsters immunized intranasally (i.n.) with HAd-Spike/C5 in...
Source: Clinical Lung Cancer - July 28, 2023 Category: Cancer & Oncology Authors: Ekramy E Sayedahmed Marcelo Valdemir Ara újo Taiana Tain á Silva-Pereira Shubhada K Chothe Ahmed Elkashif Marwa Alhashimi Wen-Chien Wang Andrea P Santos Meera Surendran Nair Abhinay Gontu Ruth Nissly Ant ônio Francisco de Souza Filho Mariana Silva Tava Source Type: research

Protease-deleted adenovirus as an alternative for replication-competent adenovirus vector
Virology. 2023 Jul 19;586:67-75. doi: 10.1016/j.virol.2023.07.009. Online ahead of print.ABSTRACTFor cancer therapy and vaccination an amplified expression of the therapeutic gene is desired. Previously, we have developed a single-cycle adenovirus vector (SC-AdV) by deleting the adenovirus protease (PS) gene. In order to keep the E1 region intact within the PS-deleted adenoviruses, we examined the insertion of two transgenes under the control of a constitutive or inducible promoters. These were inserted between E4 and the right inverted terminal repeat in a wide variety of backbones with various combinations of PS, E3 and ...
Source: Adv Data - July 24, 2023 Category: Epidemiology Authors: S Mehdy Elahi Nazila Nazemi-Moghaddam R énald Gilbert Source Type: research

Uncovering transcriptomic landscape alterations of CAN-2409 in < em > in vitro < /em > and < em > in vivo < /em > glioma models
CONCLUSION: CAN-2409 significantly alters the transcriptome both in vitro and in vivo. Comparison of pathway enrichment revealed mutual and differential utilization of pathways under both conditions, suggesting a modulating influence on the cell cycle in tumor cells, and of the tumor microenvironment on the transcriptome in vivo. IL-12 synthesis likely depends on interactions with the tumor microenvironment, and it facilitates CAN-2409 cell killing. This dataset provides potential to understand resistance mechanisms and identify potential biomarkers for future studies.PMID:37228396 | PMC:PMC10203593 | DOI:10.3389/fmed.2023.1140352
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Marilin S Koch Mykola Zdioruk Michal O Nowicki Michael S Hoetker Zachary T Herbert Francesca Barone Paul P Tak E Antonio Chiocca Ghazaleh Tabatabai Sean E Lawler Source Type: research

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