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Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3
CONCLUSIONS: This study is the first to indicate that inhibition of BRD4 delays fibrous scarring after ischemic stroke through mechanisms involving the phosphorylation of Smad2/3.PMID:36244457 | DOI:10.1016/j.brainres.2022.148126
Source: Brain Research - October 16, 2022 Category: Neurology Authors: Xuemei Li Huimin Zhu Jun Wen Jiagui Huang Yue Chen Mingfen Tian Jiangxia Ren Li Zhou Qin Yang Source Type: research

Peripherally delivered Adeno-associated viral vectors for spinal cord injury repair
In conclusion, in the future, minimally invasive administration of AAVs may improve recovery after SCI with minimal side effects.PMID:34896114 | DOI:10.1016/j.expneurol.2021.113945
Source: Experimental Neurology - December 13, 2021 Category: Neurology Authors: Jared D Sydney-Smith Aline B Spejo Philippa M Warren Lawrence D F Moon Source Type: research

Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke
We recently reported that upregulation of the constitutively active ras homolog enriched in brain [Rheb(S16H)], which induces the activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, can protect adult neurons, mediated by the induction of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in animal models of neurodegenerative diseases. Here we show that neuronal transduction of Rheb(S16H) using adeno-associated virus serotype 1 provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Rheb(S16H)-expressing neurons exhibited neurotrophic effec...
Source: NeuroReport - August 13, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research