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Infectious Disease: Influenza

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Total 27336 results found since Jan 2013.

Severe viral respiratory infections in the pre-COVID era: A 5-year experience in two pediatric intensive care units in Italy
CONCLUSIONS: Early identification of patients who could have a sudden respiratory deterioration and need of mechanical ventilation is crucial to reduce complications due to orotracheal intubation and prolonged hospitalization in PICU. Further studies are needed to define high-risk group of patients and to design targeted interventions.PMID:36193621 | DOI:10.1111/irv.13038
Source: Respiratory Care - October 4, 2022 Category: Respiratory Medicine Authors: Maia De Luca Carmen D'Amore Lorenza Romani Costanza Tripiciano Vitangelo Clemente Stefania Mercadante Daniela Perrotta Joseph Nunziata Corrado Cecchetti Emanuele Rossetti Roberto Bianchi Carlo Federico Perno Paola Bernaschi Cristina Russo Laura Lancella M Source Type: research

Delirium Upon Presentation to the Pediatric Emergency Department: A Case Series
The following cases describe children who presented to the emergency department (ED) with a constellation of symptoms consistent with delirium. In each case, there was no identified inciting cause (eg, fever, medications) other than the presence of influenza. All children had variable workups, with 2 children undergoing extensive neurologic evaluation and testing. Clinical recognition of delirium in the pediatric acute care setting can be challenging, but heightened awareness by ED and primary care physicians may lead to earlier diagnosis, prevent unwarranted investigations, and decrease hospitalization. Children with infl...
Source: Pediatric Emergency Care - August 1, 2018 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Critical care management of adults with community-acquired severe respiratory viral infection
AbstractWith the expanding use of molecular assays, viral pathogens are increasingly recognized among critically ill adult patients with community-acquired severe respiratory illness; studies have detected respiratory viral infections (RVIs) in 17 –53% of such patients. In addition, novel pathogens including zoonotic coronaviruses like the agents causing Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the 2019 novel coronavirus (2019 nCoV) are still being identified. Patients with severe RVIs requiring ICU care present typically with hypoxemic respiratory failure. Oseltamivir is the ...
Source: Intensive Care Medicine - February 9, 2020 Category: Intensive Care Source Type: research

SCCM Pod-422 Procalcitonin in COVID-19 and Influenza-Related Secondary Bacterial Infections
Procalcitonin testing on admission seems to be a valuable piece of information for early risk assessment and ruling out bacterial co-infection in COVID-19 patients.
Source: SCCM PodCast - iCritical Care - September 24, 2020 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

Deadly H7N9 Influenza Virus: A Pandemic in the Making or a Warning Lesson?
PMID: 23815712 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2013 Category: Respiratory Medicine Authors: Lamb RA Tags: Am J Respir Crit Care Med Source Type: research

Population-Based Incidence Estimates of Influenza-Associated Respiratory Failure Hospitalizations, 2003 - 2009.
Conclusion: Our data indicate that influenza was an important contributor to respiratory failure hospitalizations during 2003-2009. Physicians should consider influenza testing and empiric antiviral therapy for hospitalized patients with severe acute respiratory disease during periods of influenza activity. Influenza has a greater effect on respiratory failure in the elderly, for whom better prevention measures are needed. PMID: 23855650 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2013 Category: Respiratory Medicine Authors: Ortiz JR, Neuzil KM, Rue TC, Zhou H, Shay DK, Cheng PY, Cooke CR, Goss CH Tags: Am J Respir Crit Care Med Source Type: research

Mucosal Immune Responses Predict Clinical Outcomes during Influenza Infection Independently of Age and Viral Load.
Conclusions: An innate profile was identified that correlated with disease progression independent of viral dynamics and age. The airways and blood displayed dramatically different immune profiles emphasizing the importance of cellular migration and localized immune phenotypes. PMID: 24308446 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 5, 2013 Category: Respiratory Medicine Authors: Oshansky CM, Gartland AJ, Wong SS, Jeevan T, Wang D, Roddam PL, Caniza MA, Hertz T, Devincenzo JP, Webby RJ, Thomas PG Tags: Am J Respir Crit Care Med Source Type: research

Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation.
Conclusion: MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung. PMID: 24417465 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 13, 2014 Category: Respiratory Medicine Authors: Kim WK, Jain D, Sánchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA, Frieman MB, López CB Tags: Am J Respir Crit Care Med Source Type: research

High ICU admission rate for 2013-2014 Influenza is associated with a low rate of vaccination.
PMID: 24512430 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 10, 2014 Category: Respiratory Medicine Authors: Catania J, Que LG, Govert JA, Hollingsworth JW, Wolfe CR Tags: Am J Respir Crit Care Med Source Type: research

It Is Time for a Comprehensive Analytical Approach in Clinical Studies. Virus-versus-Host Interaction and Influenza Disease Severity.
PMID: 24528315 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2014 Category: Respiratory Medicine Authors: Ramilo O, Mejias A Tags: Am J Respir Crit Care Med Source Type: research

Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection.
Conclusions: Early negative A(H1N1) 2009 HI serology can predict death from influenza. This negative serology in fatal cases in young adults reflects the trapping of anti-H1N1 antibodies in immune complexes in the lungs, associated with poor specific helper T-cell response. PMID: 24646009 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 19, 2014 Category: Respiratory Medicine Authors: Guihot A, Luyt CE, Parrot A, Rousset D, Cavaillon JM, Boutolleau D, Fitting C, Pajanirassa P, Mallet A, Fartoukh M, Agut H, Musset L, Zoorob R, Kirilovsky A, Combadière B, Van der Werf S, Autran B, Carcelain G, the FluBAL study group Tags: Am J Respir Crit Care Med Source Type: research

Loss of TLR4 Does Not Prevent Influenza A-induced Mortality.
PMID: 24832747 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2014 Category: Respiratory Medicine Authors: Morales-Nebreda L, Mutlu GM, Scott Budinger GR, Radigan KA Tags: Am J Respir Crit Care Med Source Type: research

Markers of prognosis specific to influenza infection: are we there yet?
PMID: 24832741 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2014 Category: Respiratory Medicine Authors: Radigan KA, Mutlu GM Tags: Am J Respir Crit Care Med Source Type: research

Extracorporeal Life Support in Critically Ill Adults.
Abstract Extracorporeal life support (ECLS) has become increasingly popular as a salvage strategy for critically ill adults. Major advances in technology and the severe acute respiratory distress syndrome (ARDS) that characterized the 2009 influenza A (H1N1) pandemic have stimulated renewed interest in the use of veno-venous extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) to support the respiratory system. Theoretical advantages of ECLS for respiratory failure include the ability to rest the lungs by avoiding injurious mechanical ventilator settings and the potential t...
Source: American Journal of Respiratory and Critical Care Medicine - July 21, 2014 Category: Respiratory Medicine Authors: Ventetuolo CE, Muratore CS Tags: Am J Respir Crit Care Med Source Type: research

Asymptomatic HIV-infected Individuals on Antiretroviral Therapy Exhibit Impaired Lung CD4(+) T Cell Responses to Mycobacteria.
Conclusion. AM and mycobacteria-specific alveolar CD4+ T cell responses in HIV-infected adults on ART for <4 years are impaired and may partly explain the high risk of TB in HIV-infected individuals on ART. Strategies to augment ART to improve lung immune cell function and reduce the high incidence of TB in HIV-infected adults who initiate ART should be investigated. PMID: 25225948 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 16, 2014 Category: Respiratory Medicine Authors: Jambo KC, Banda DH, Afran L, Kankwatira AM, Malamba RD, Allain TJ, Gordon SB, Heyderman RS, Russell DG, Mwandumba HC Tags: Am J Respir Crit Care Med Source Type: research