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Infectious Disease: Influenza

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Total 27336 results found since Jan 2013.

Asthma Phenotypes and COVID-19 Risk: A Population-based Observational Study
CONCLUSIONS: More severe asthma was associated with more severe COVID-19 outcomes, but type-2 inflammation was not. The risk of COVID-19 hospitalisation appeared to be similar to the risk with influenza or pneumonia. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:34669568 | DOI:10.1164/rccm.202107-1704OC
Source: American Journal of Respiratory and Critical Care Medicine - October 20, 2021 Category: Respiratory Medicine Authors: Chloe I Bloom Paul Cullinan Jadwiga A Wedzicha Source Type: research

Long-term Air Pollution Exposure and Pneumonia Related Mortality in a Large Pooled European Cohort
CONCLUSIONS: Long-term exposure to combustion-related air pollutants NO2 and BC may be associated with mortality from lower respiratory infections, but larger studies are needed to estimate these associations more precisely.PMID:35258439 | DOI:10.1164/rccm.202106-1484OC
Source: American Journal of Respiratory and Critical Care Medicine - March 8, 2022 Category: Respiratory Medicine Authors: Shuo Liu Youn-Hee Lim Jie Chen Maciek Strak Kathrin Wolf Gudrun Weinmayr Sophia Rodopolou Kees de Hoogh Tom Bellander J ørgen Brandt Hans Concin Emanuel Zitt Daniela Fecht Francesco Forastiere John Gulliver Ole Hertel Barbara Hoffmann Ulla A Hvidtfeldt W Source Type: research

Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19
CONCLUSIONS: Our data suggest that patients with severe COVID-19 harbor IgA against pulmonary surfactant proteins B and C and that these antibodies block the function of lung surfactant, potentially contributing to alveolar collapse and poor oxygenation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:35926164 | DOI:10.1164/rccm.202201-0011OC
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2022 Category: Respiratory Medicine Authors: Tobias Sinnberg Christa Lichtensteiger Omar Hasan Ali Oltin T Pop Ann-Kristin Jochum Lorenz Risch Silvio D Brugger Ana Velic David Bomze Philipp Kohler Pietro Vernazza Werner C Albrich Christian R Kahlert Maire-Therese Abdou Nina Wyss Kathrin Hofmeister H Source Type: research

Anti-Viral Responses of Tissue-Resident CD49a+ Lung NK Cells Are Dysregulated in COPD
CONCLUSIONS: Collectively, these results demonstrate that tissue-resident NK cell function is altered in cigarette smoke-induced disease and suggests that smoke exposure may aberrantly prime tissue-resident NK cell responsiveness to viral infection. This may contribute to excess inflammation during viral exacerbations of COPD.PMID:36170617 | DOI:10.1164/rccm.202205-0848OC
Source: American Journal of Respiratory and Critical Care Medicine - September 28, 2022 Category: Respiratory Medicine Authors: Grace E Cooper Jemma Mayall Chantal Donovan Tatt J Haw Kurtis F Budden Evy E Blomme Tania Maes Chia Wei Kong Jay C Horvat Salim I Khakoo Tom M A Wilkinson Philip M Hansbro Karl J Staples Source Type: research

Critical care resource allocation: trying to PREEDICCT outcomes without a crystal ball
Despite pandemic influenza's long reign atop the list of potential medical catastrophes, the first protocol designed to support critical care triage in a pandemic was published only in 2006. InFACT (the International Forum of Acute Care Trialists) was formed in 2009 and provided a platform for international critical care research collaboration during the 2009-2010 Influenza A(H1N1) pandemic. Over the past 2 years, a number of working groups have emerged from InFACT focused upon improving the investigation and care of patients with severe respiratory illness. Arising from these efforts, in June of 2012, an international gro...
Source: BioMed Central - January 23, 2013 Category: Journals (General) Authors: Michael D ChristianRobert FowlerMatthew P MullerCharles GomersallCharles L SprungNathaniel HupertDavid FismanAndrew TillyardDavid ZygunJohn C MarshalPREEDICCT Study Group Source Type: research

Optimizing pediatric clinical care and advocacy in an online era: Report of the Canadian Paediatric Society Infectious Diseases and Immunization Committee.
CONCLUSION: Learn where to find this new and continuously changing information and how to stay evergreen in your knowledge. PMID: 25022634 [PubMed - as supplied by publisher]
Source: Canadian Family Physician Medecin de Famille Canadien - July 1, 2014 Category: Primary Care Authors: Dollin J Tags: Can Fam Physician Source Type: research

Impact of Viral Seasonal Outbreaks on Crowding and Health Care Quality in Pediatric Emergency Departments
In conclusion, seasonal viral outbreaks have a strong impact on crowding and quality of care. The evolution of “patients left without being seen” between the first and fourth quartiles of DEL could be used as an indicator reflecting the capacity of adaptation of an emergency department to outbreaks.
Source: Pediatric Emergency Care - December 1, 2021 Category: Emergency Medicine Tags: Original Articles Source Type: research

Management of Severe Influenza
Semin Respir Crit Care Med 2021; 42: 771-787 DOI: 10.1055/s-0041-1735491Influenza infection causes severe illness in 3 to 5 million people annually, with up to an estimated 650,000 deaths per annum. As such, it represents an ongoing burden to health care systems and human health. Severe acute respiratory infection can occur, resulting in respiratory failure requiring intensive care support. Herein we discuss diagnostic approaches, including development of CLIA-waived point of care tests that allow rapid diagnosis and treatment of influenza. Bacterial and fungal coinfections in severe influenza pneumonia are associated with...
Source: Seminars in Respiratory and Critical Care Medicine - December 16, 2021 Category: Respiratory Medicine Authors: O'Driscoll, Liam S. Martin-Loeches, Ignacio Tags: Review Article Source Type: research

The Occurrence and Impact of Bacterial Organisms Complicating Critical Care Illness Associated with Influenza A(H1N1) infection.
CONCLUSION: Culture-based evidence of secondary infections commonly complicates Influenza A(H1N1)-related critical illness and is associated with worse clinical outcomes despite nearly ubiquitous antibiotic administration. PMID: 23392627 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Muscedere J, Ofner M, Kumar A, Long J, Lamontagne F, Cook D, McGeer A, Chant C, Marshall J, Jouvet P, Fowler R Tags: Chest Source Type: research

Influenza-Associated Critical Illness: Estimating the Burden and the Burden of Estimation*
No abstract available
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Editorials Source Type: research

Novel Avian-Origin Influenza A (H7N9) in Critically Ill Patients in China*
Conclusions: Infection with novel avian-origin reassortment influenza A (H7N9) virus is characterized by high fever, cough, and severe respiratory failure and is associated with a high mortality. These data provide some general understandings for the early identification, ICU treatment, and short-term prognosis of hospitalized critical patients with H7N9.
Source: Critical Care Medicine - January 17, 2015 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Identifying Prioritization Criteria to Supplement Critical Care Triage Protocols for the Allocation of Ventilators during a Pandemic Influenza
The purpose of this study was to identify supplementary criteria to provide direction when the Ontario Health Plan for an Influenza Pandemic (OHPIP) critical care triage protocol is rendered insufficient by its inability to discriminate among patients assessed as urgent, and there are insufficient critical care resources available to treat those in that category. To accomplish this task, a Supplementary Criteria Task Force for Critical Care Triage was struck at the University of Toronto Joint Centre for Bioethics. The task force reviewed publically available protocols and policies on pandemic flu planning, identified 13 po...
Source: Healthcare Quarterly - April 30, 2014 Category: Global & Universal Source Type: research

Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain–Containing Protein-2 Critically Regulates Influenza A Virus–Induced Pneumonia
Conclusions: These data support an important function of sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain–containing protein-2 in controlling influenza virus–induced pneumonia and viral replication. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain–containing protein-2 may be a novel therapeutic target for controlling the immune response against influenza influenza A virus infection.
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research