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Infectious Disease: Herpes

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Total 620 results found since Jan 2013.

Thioxothiazolo3,4-aquinazoline derivatives inhibit the human cytomegalovirus alkaline nuclease
In this study, we validated the HCMV AN, encoded by the viral UL98 open reading frame, as a drug target by demonstrating that a UL98-deficient HCMV mutant is severely attenuated and shows a reduced ability to spread in cell culture. We established a fluorescence-based enzyme assay suitable for high-throughput screening and used it on a small-molecule compound library. The most promising hit, a thioxothiazolo[3,4-a]quinazoline derivative, blocked AN activity in vitro and inhibited HCMV replication in plaque reduction (PRA) and fluorescence reduction assays (FRA). Several derivatives of the hit compound were tested, some of ...
Source: Antiviral Research - August 4, 2023 Category: Virology Authors: Tianyu Zhang Theodore I Potgieter Erik Kosche Jessica R ückert Eleonore Ostermann Thomas Schulz Martin Empting Wolfram Brune Source Type: research

Viruses, Vol. 15, Pages 1651: Mechanistic Understanding of the Antiviral Properties of Pistachios and Zeaxanthin against HSV-1
a Sciortino The search for alternative clinical treatments to fight resistance and find alternative antiviral treatments for the herpes simplex virus (HSV) is of great interest. Plants are rich sources of novel antiviral, pharmacologically active agents that provide several advantages, including reduced side effects, less resistance, low toxicity, and different mechanisms of action. In the present work, the antiviral activity of Californian natural raw (NRRE) and roasted unsalted (RURE) pistachio polyphenols-rich extracts was evaluated against HSV-1 using VERO cells. Two different extraction methods, with or without n-...
Source: Viruses - July 29, 2023 Category: Virology Authors: Rosamaria Pennisi Paola Trischitta Maria Pia Tamburello Davide Barreca Giuseppina Mandalari Maria Teresa Sciortino Tags: Article Source Type: research

Rapid detection of varicella-zoster virus based on an immunochromatographic strip
In this study, VZV gE protein, expressed in CHO cells, was used to immunize BALB/c mice for the generation of monoclonal antibodies (mAbs). For the first time, we developed a colloidal gold-based immunochromatographic strip for rapid detection of VZV using a pair of mAbs against gE protein. The limit of detection (LOD) of the strip was 30 ng mL-1 of purified VZV gE antigen, and it could specifically test VZV without cross-reactivity with Enterovirus 71 (EV-71), Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2). The coincidence rate between the strip and commercial real-time PCR diagnostic kit was 100% using...
Source: Virology - July 23, 2023 Category: Virology Authors: Aiping Wang Yan Niu Jianguo Zhao Hongliang Liu Peiyang Ding Yumei Chen Jingming Zhou Xifang Zhu Ying Zhang Chao Liang Gaiping Zhang Source Type: research

Novel UL23 and UL30 substitutions in HSV1 and HSV2 viruses related to polymorphism or drug resistance
Antiviral Res. 2023 Jul 13:105672. doi: 10.1016/j.antiviral.2023.105672. Online ahead of print.ABSTRACTData on herpes simplex virus (HSV) polymorphism as well as acyclovir (ACV) and foscarnet (FOS) resistance mutations are not exhaustive and may hinder accurate diagnosis by next-generation sequencing (NGS). Here, we report novel UL23 and UL30 substitutions for HSV1 and HSV2 identified in immunocompromised patients treated for hematological malignancies during the last 6 years of HSV resistance surveillance at the University Hospital of Lyon. For HSV1, 35 novel UL23 substitutions and 52 novel UL30 substitutions were identif...
Source: Antiviral Research - July 15, 2023 Category: Virology Authors: J Giorgi B Simon G Destras Q Semanas C Ginevra T Boyer H Regue G Billaud S Ducastelle F Ader F Morfin L Josset E Frobert Source Type: research

Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection
Antiviral Res. 2023 Jul 8:105666. doi: 10.1016/j.antiviral.2023.105666. Online ahead of print.ABSTRACTZika virus (ZIKV) has garnered global attention due to its association with severe congenital defects including microcephaly. However, there are no licensed vaccines or drugs against ZIKV infection. Pregnant women have the greatest need for treatment, making drug safety crucial. Alpha-linolenic acid (ALA), a polyunsaturated ω-3 fatty acid, has been used as a health-care product and dietary supplement due to its potential medicinal properties. Here, we demonstrated that ALA inhibits ZIKV infection in cells without loss of ...
Source: Antiviral Research - July 10, 2023 Category: Virology Authors: Yifei Feng Yan Yang Shuting Zou Shuqi Qiu Hao Yang Yi Hu Guifen Lin Xingang Yao Shuwen Liu Min Zou Source Type: research

Viruses, Vol. 15, Pages 1457: ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
ai Ma The strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection of viruses in permissive cells, but its role in the HSV-1 life cycle is still unclear. Here, we demonstrated that the HSV-1 immediate early (IE) gene ICP4 inhibits protein kinase A (PKA) phosphorylation to induce Rap1b-activation-mediated viral infection. Rap1b activation and membrane enrichment begin at the early stage of HSV-1 infection and remain active during the proliferation period of the virus. Treating the cells with Ra...
Source: Viruses - June 27, 2023 Category: Virology Authors: Beibei Zhang Juntao Ding Zhenghai Ma Tags: Article Source Type: research

The antiviral potential of Phyllanthus species: a systematic review
AbstractViral infections and diseases caused by viruses are worldwide problems. According to a WHO report, three to five million people are chronically infected with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) each year globally. Since some viruses mutate very quickly, developing antiviral drugs can be a daunting task. Moreover, currently used synthetic drugs are toxic and associated with side effects. Therefore, there is a need to search for alternative natural remedies that have low toxicity, a new mechanism of action, and no major side effects.Phyllanthus plants have traditio...
Source: Archives of Virology - June 13, 2023 Category: Virology Source Type: research

Herpes simplex virus infected cell protein 8 is required for viral inhibition of the cGAS pathway
In this study, we found that the HSV-1 ICP8 protein is required for viral inhibition of the cGAS pathway by reducing cGAMP levels stimulated by double-stranded DNA transfection. ICP8 alone inhibited the cGAMP response and may inhibit cGAS action by direct interaction with DNA, cGAS, or other infected cell proteins. Our results reveal another cGAS antiviral pathway inhibitor and highlight the importance of countering IFN for efficient viral replication.PMID:37271042 | DOI:10.1016/j.virol.2023.05.002
Source: Virology - June 4, 2023 Category: Virology Authors: Nicole Broekema Max E Mertens Magdalena Angelova Megan H Orzalli Hyung S Oh David M Knipe Source Type: research

B virus
Uirusu. 2021;71(2):125-136. doi: 10.2222/jsv.71.125.ABSTRACTB virus is a herpes virus that natutaly infects macaque monkeys. It is extremely neuropathogenic when infection occurs in humans. B virus infection has been reported only in laboratory workers and breeders of macaque monkeys in North America and the United Kingdom, and it is therefore recognized as a rare infectious disease. The first cases of B virus disease were reported in Japan in 2019 and in China in 2021, although no cases had been reported since 1997. Although B virus disease has not been reported for more than 20 years, the potential threat has always exis...
Source: Uirusu. Journal of Virology - May 28, 2023 Category: Virology Source Type: research