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Infectious Disease: Hepatitis
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Hepatocyte steatosis inhibits hepatitis B virus secretion via induction of endoplasmic reticulum stress
Mol Cell Biochem. 2021 May 13. doi: 10.1007/s11010-021-04143-z. Online ahead of print.ABSTRACTThe effects of hepatocyte steatosis on hepatitis B virus (HBV) DNA replication and HBV-related antigen secretion are incompletely understood. The aims of this study are to explore the effects and mechanism of hepatocyte steatosis on HBV replication and secretion. Stearic acid (SA) and oleic acid (OA) were used to induce HepG2.2.15 cell steatosis in this study. The expressions of glucose-regulated protein 78 (GRP78), phosphorylation of protein kinase R-like endoplasmic reticulum (ER) kinase (p-PERK), and eukaryotic translation init...
Source: Molecular and Cellular Biochemistry - May 13, 2021 Category: Biochemistry Authors: Qichuang Liu Maoyuan Mu Huan Chen Guoyuan Zhang Yanqing Yang Jun Chu Ying Li Fangwan Yang Shide Lin Source Type: research
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation
In conclusion, CCDC88A/GIV enhanced HBV replication by increasing endosomal trafficking and reducing autophagic degradation of HBV antigens, suggesting that CCDC88A/GIV-mediated endosomal trafficking plays an important role in HBV replication and progeny secretion.AbbreviationsACTB: actin beta; AO: acridine orange; ATF6: activating transcription factor 6; CCDC88A/GIV: coiled-coil domain containing 88A; CLTC: clathrin heavy chain; CQ: chloroquine; DAPI: 4',6-diamidino-2-phenylindole; DNM2: dynamin 2; ER: endoplasmic reticulum; ERN1: endoplasmic reticulum to nucleus signaling 1; EIF2A: eukaryotic translation initiation facto...
Source: Autophagy - June 30, 2021 Category: Cytology Authors: Xueyu Wang Zhiqiang Wei Tingyu Lan Yulin He Bin Cheng Ruimin Li Hongxia Chen Fahong Li Guohua Liu Bin Jiang Yong Lin Mengji Lu Zhongji Meng Source Type: research
Blocking neddylation elicits antiviral effect against hepatitis B virus replication
CONCLUSION: The manipulation of the neddylation pathway can thus provide new tools interfering with HBV persistence as well as novel therapeutic strategies against chronic hepatitis B.PMID:34716866 | DOI:10.1007/s11033-021-06886-w
Source: Molecular Biology Reports - October 30, 2021 Category: Molecular Biology Authors: Karima Abounouh Mohammad Enamul Hoque Kayesh Haya Altawalah Bouchra Kitab Shuko Murakami Shintaro Ogawa Yasuhito Tanaka Hind Dehbi Pascal Pineau Michinori Kohara Soumaya Benjelloun Kyoko Tsukiyama-Kohara Sayeh Ezzikouri Source Type: research
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3
Toxicol Appl Pharmacol. 2021 Nov 12:115795. doi: 10.1016/j.taap.2021.115795. Online ahead of print.ABSTRACTA chronic liver disease named autoimmune hepatitis (AIH) will carry elevated levels of inflammatory cytokines, but there is currently no effective treatment to cure it. Histone deacetylase 3 (HDAC3) takes an important position in regulating the expression of inflammatory genes. Nimbolide (NIB) is a limonoid extracted from the neem tree (Azadirachta indica) that has been found to be effective against many diseases, including cancer, scleroderma, and acute respiratory distress syndrome. Here, we investigated the protect...
Source: Toxicology and Applied Pharmacology - November 15, 2021 Category: Toxicology Authors: Dingchao Xia Dazhi Chen Tingchen Cai Lujian Zhu Yanhan Lin Sijie Yu Kailu Zhu Xiaodong Wang Lanman Xu Yongping Chen Source Type: research
Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
Biomed Pharmacother. 2021 Dec;144:112372. doi: 10.1016/j.biopha.2021.112372. Epub 2021 Oct 28.ABSTRACTSmall- and intermediate-conductance Ca2+-activated K+ channels, KCa2.3 and KCa3.1, are involved in cellular signaling processes associated with inflammation and fibrosis. KCa2.3 and KCa3.1 are upregulated by proinflammatory cytokines and profibrotic growth factors. Cyclic AMP, which downregulates KCa2.3 and KCa3.1, is elevated by modafinil in cells; accordingly, we investigated whether modafinil exerts anti-inflammatory and anti-fibrotic responses via KCa2.3- and KCa3.1-mediated pathways in high-fat diet (HFD)- or thioacet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2021 Category: Drugs & Pharmacology Authors: Shinkyu Choi Ji Aee Kim Haiyan Li Seong-Eun Jo Huisu Lee Tae Hun Kim Minje Kim Seong-Jin Kim Suk Hyo Suh Source Type: research
