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Total 1369 results found since Jan 2013.

Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U-ACHIEVE Maintenance): overall results from the randomised, placebo-controlled, double-blind, phase 3 maintenance study
Lancet Gastroenterol Hepatol. 2023 Sep 5:S2468-1253(23)00208-X. doi: 10.1016/S2468-1253(23)00208-X. Online ahead of print.ABSTRACTBACKGROUND: Upadacitinib is an oral, selective, and reversible JAK inhibitor with demonstrated efficacy in patients with moderately to severely active ulcerative colitis in a phase 2b induction trial, two phase 3 induction trials (U-ACHIEVE Induction and U-ACCOMPLISH), and a primary analysis of the first 451 patients entering a subsequent maintenance trial (U-ACHIEVE Maintenance). Here, we present overall results from the entire U-ACHIEVE Maintenance population.METHODS: In this randomised, place...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: S éverine Vermeire Silvio Danese Wen Zhou Dapo Ilo Justin Klaff Gweneth Levy Xuan Yao Su Chen Yuri Sanchez Gonzalez Xavier H ébuterne James O Lindsay Peter D R Higgins Qian Cao Hiroshi Nakase Jean-Fr édéric Colombel Edward V Loftus Remo Panaccione Source Type: research

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research

Greater executive dysfunction in patients post-COVID-19 compared to those not infected
Brain Behav Immun. 2023 Aug 14:S0889-1591(23)00237-4. doi: 10.1016/j.bbi.2023.08.014. Online ahead of print.ABSTRACTBACKGROUND: A number of patients post-coronavirus disease-19 (COVID-19) report cognitive impairment (CI), even months after acute infection. We aimed to assess if COVID-19 is associated with increased incidence of CI in comparison to controls.METHODS: We analyzed data from the Mount Sinai Health System Post-COVID-19 Registry in New York City, a prospective cohort of patients post-COVID-19 ≥18 years of age and non-infected controls. CI was defined by scores ≥1.0 standard deviation below population norms, a...
Source: Brain, Behavior, and Immunity - August 16, 2023 Category: Neurology Authors: Jacqueline H Becker Jenny J Lin Akosua Twumasi Ruchir Goswami Fernando Carnavali Kimberly Stone Monica Rivera-Mindt Minal S Kale Georges Naasan Joanne R Festa Juan P Wisnivesky Source Type: research

Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis
We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.METHODS: Seven Study Contributors in Europe collected data on individuals aged ≥18 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed ≥14 days prior to symptom onset; no booster doses) or unvaccinated (...
Source: Herpes - August 7, 2023 Category: Infectious Diseases Authors: Wilhelmine Meeraus Leonie de Munter Christen M Gray Akshat Dwivedi Chlo é Wyndham-Thomas Mario Ouwens Wendy Hartig-Merkel Laura Drikite Griet Rebry Antonio Carmona Anke L Stuurman Thi Yen Chi Nguyen Guillermo Mena Ainara Mira-Iglesias Giancarlo Icardi Su Source Type: research

Long-running ProMED email service for alerting world to disease outbreaks is in trouble
The first news about the COVID-19 pandemic came not from a government or a scientific publication, but in an email from a disease-alert system called ProMED . This fateful missive in December 2019 about a few cases of a mysterious pneumonia in Wuhan, China, is just one example of how physicians and public health experts around the world have used the 30-year-old, free service to share real-time information about local disease outbreaks with tens of thousands of subscribers. But ProMED is now on life support. Much of its work came to a screeching halt yesterday when 21 of its 38 paid editors and moderators went o...
Source: Science of Aging Knowledge Environment - August 4, 2023 Category: Geriatrics Source Type: research

Preparing for Future Pandemics and Public Health Emergencies: An American College of Physicians Policy Position Paper
Ann Intern Med. 2023 Jul 25. doi: 10.7326/M23-0768. Online ahead of print.ABSTRACTThe onset of the COVID-19 pandemic revealed significant gaps in the United States' pandemic and public health emergency response system. At the federal level, government responses were undercut by a lack of centralized coordination, inadequately defined responsibilities, and an under-resourced national stockpile. Contradictory and unclear guidance throughout the early months of the pandemic, along with inconsistent funding to public health agencies, also created notable variance in state and local responses. The lack of a coordinated response...
Source: Annals of Internal Medicine - July 24, 2023 Category: Internal Medicine Authors: Josh Serchen Katelan Cline Suja Mathew David Hilden Health and Public Policy Committee of the American College of Physicians* Source Type: research

Development of CRISPR/Cas13a-based assays for the diagnosis of Schistosomiasis
EBioMedicine. 2023 Jul 22;94:104730. doi: 10.1016/j.ebiom.2023.104730. Online ahead of print.ABSTRACTBACKGROUND: Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated the development of a revolutionary and powerful diagnostics platform, resulting in the advancement of a class of ultrasensitive, specific, cost-effective and portable diagnostics, typified by applications in COVID-19/cancer diagnosis.METHODS: We developed CRISPR-based diagnostic platform SHERLO...
Source: Cancer Control - July 24, 2023 Category: Cancer & Oncology Authors: Skye R MacGregor Donald P McManus Haran Sivakumaran Thomas G Egwang Moses Adriko Pengfei Cai Catherine A Gordon Mary G Duke Juliet D French Natasha Collinson Remigio M Olveda Gunter Hartel Carlos Graeff-Teixeira Malcolm K Jones Hong You Source Type: research