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COVID-19-Associated Acute Brain Dysfunction Related to Sepsis
J Clin Med Res. 2021 Feb;13(2):82-91. doi: 10.14740/jocmr4437. Epub 2021 Feb 25.ABSTRACTIn global term, as of November 30, 2020, over 30 million people has been infected by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10,000,000 of them died of acute organ failure. Our reviews have shown that coronavirus disease 2019 (COVID-19) patients with pneumonia and acute respiratory distress syndrome (ARDS) have life-threatening acute brain dysfunction (ABD), ranging from altered mental status/delirium to stupor/coma. Altered mental status/delirium was the most common manifestation of ABD cause...
Source: Clin Med Res - March 22, 2021 Category: Research Authors: Dao Ming Tong Ye Ting Zhou Yuan Wei Wang Source Type: research

COVID-19's Clinical-Pathological Evidence in Relation to Its Repercussion on the Central and Peripheral Nervous System
CONCLUSION: The neurological implications of COVID-19 range from initial symptoms, such as headache, to serious complications, such as ischemic stroke. Although the pathogenesis of neurological phenomena requires further studies, targeted management of the patient is feasible, considering agility in recognizing the infection. Therefore, medical precaution and clinical reasoning are emphasized when providing services to the patient.PMID:35137375 | DOI:10.1007/978-3-030-85113-2_11
Source: Advances in Experimental Medicine and Biology - February 9, 2022 Category: Research Authors: Amanda Menezes Morgado Ana Luiza Menezes Santana Bezerra Esther Barbosa Gon çalves Felix Jos é Correia Saraiva Júnior Nat ália Bitú Pinto Modesto Leite Rolim Neto Ana Lu íza de Aguiar Rocha Martin Source Type: research

Rapid improvement in severe long COVID following perispinal etanercept
CONCLUSION: Perispinal etanercept is a promising treatment for the chronic neurologic dysfunction that may persist after resolution of acute COVID-19, including chronic cognitive dysfunction, fatigue, and depression. These results suggest that long COVID brain neuroinflammation is a potentially reversible pathology and viable treatment target. In view of the increasing unmet medical need, clinical trials of perispinal etanercept for long COVID are urgently necessary. The robust results of the present case suggest that perispinal etanercept clinical trials studying long COVID populations with severe fatigue, depression and ...
Source: Current Medical Research and Opinion - July 6, 2022 Category: Research Authors: Edward Tobinick Robert N Spengler Tracey A Ignatowski Manar Wassel Samantha Laborde Source Type: research

Comparison of Clinical Outcomes in Patients with ST Elevation Myocardial Infarction with Percutaneous Coronary Intervention and the Use of a Telemedicine App Before and After the COVID-19 Pandemic at a Center in Beijing, China, from August 2019 to March 2020.
CONCLUSIONS Telemedicine reduced the delay time of STEMI patients during the COVID-19 pandemic. The difference in short-term adverse clinical outcomes was not statistically significant between patients who used the app and those who did not. PMID: 32938901 [PubMed - in process]
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far?
Adv Exp Med Biol. 2021;1321:21-31. doi: 10.1007/978-3-030-59261-5_2.ABSTRACTThe recently emerged coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, is the newest threat to human health. It has already infected more than 54.5 million people worldwide, currently leading to more than 1.3 million deaths. Although it causes a mild flu-like disease in most patients, lethality may increase to more than 20% in elderly subjects, especially in those with comorbidities, like hypertension, diabetes, or lung and cardiac disease, and the mechanisms are still elusive. Common symp...
Source: Advances in Experimental Medicine and Biology - March 3, 2021 Category: Research Authors: Isabelle Pastor Bandeira Marco Ant ônio Machado Schlindwein Leticia Caroline Breis Jean Pierre Schatzmann Peron Marcus Vin ícius Magno Gonçalves Source Type: research

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