• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke.
We examined risk factors for unfavorable outcome following stroke occurrence including serum antibody titers to periodontal pathogens. The enrolled cohort included 534 patients who had experienced an acute stroke, who were divided into favorable (n=337) and unfavorable (n=197) outcome groups according to modified ranking scale (mRS) score determined at 3 months after onset (favorable: score 0 or 1, unfavorable: score 2 to 6. The associations of risk factors with unfavorable outcome, including serum titers of IgG antibodies to 16 periodontal pathogens, were examined. Logistic regression analysis showed that the initial Nati...
Source: Clinical and Developmental Immunology - March 9, 2020 Category: Allergy & Immunology Authors: Nishi H, Hosomi N, Ohta K, Aoki S, Nakamori M, Nezu T, Shigeishi H, Shintani T, Obayashi T, Ishikawa K, Kinoshita N, Shiga Y, Sugiyama M, Ohge H, Maruyama H, Kawaguchi H, Kurihara H Tags: Clin Exp Immunol Source Type: research

Lemierre's syndrome with stroke and stenosis of the internal carotid artery suggesting focal vasculitis
Here we present a patient with oropharynx infection by Fusobacterium necrophorum (F. necrophorum) who developed arterial wall inflammation and longitudinal stenosis of the right internal carotid artery and right hemispheric ischemic stroke. To our knowledge, longitudinal stenosis caused by F. necrophorum in Lemierre's syndrome has not previously been described.
Source: Journal of the Neurological Sciences - December 10, 2019 Category: Neurology Authors: Dewah Rahimi, Annika Reynberg Langkilde, Helle Klingenberg Iversen, Thomas Clement Truelsen Tags: Letter to the Editor Source Type: research

A case of Lemierre's syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism
We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre's syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated ...
Source: Journal of the Royal College of Physicians of Edinburgh - September 7, 2023 Category: General Medicine Authors: Charlotte J Dewdney Joseph J Anderson Simon Dewar Fergus Doubal Frederick R Burgess Deepak Subedi Marcus J Lyall Source Type: research

Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
We report the case of an adolescent who presented with febrile meningism and stupor. Clinical, biological, and radiological features favored the diagnosis of Lemierre syndrome (LS), with Fusobacterium necrophorum infection (sphenoid sinusitis and meningitis) and intracranial vasculitis. The patient had concurrent SARS-CoV-2 infection. Despite medical and surgical antimicrobial treatment, stroke prevention, and venous thrombosis prevention, he presented with severe cerebrovascular complications. Venous thrombosis and stroke were observed, with an extension of intracranial vasculitis, and lead to death. As both F. necrophoru...
Source: Frontiers in Neurology - April 8, 2021 Category: Neurology Source Type: research

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Pages: 1  2