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Infectious Disease: Gastroenteritis

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Total 46825 results found since Jan 2013.

Rational Design of a Chimeric Derivative of PcrV as a Subunit Vaccine Against Pseudomonas aeruginosa
In this study, the full-length PcrV was divided into four domains with the guidance of its structure, and the Nter domain (Met1-Lys127) and H12 domain (Leu251-Ile294) were found to be immunodominant. Subsequently, Nter and H12 were combined with a flexible linker to generate an artificial PcrV derivative (PcrVNH). PcrVNH was successfully produced in E. coli and behaved as a homogenous monomer. Moreover, immunization with PcrVNH elicited a multifactorial immune response and conferred broad protection in an acute PA pneumonia model and was equally effective to full-length PcrV. In addition, passive immunization with anti-Pcr...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Resistome and microbial profiling of pediatric patient's gut infected with multidrug-resistant diarrhoeagenic < em > Enterobacteriaceae < /em > using next-generation sequencing; the first study from Pakistan
Libyan J Med. 2021 Dec;16(1):1915615. doi: 10.1080/19932820.2021.1915615.ABSTRACTA high prevalence of multidrug-resistant (MDR) pathogens has been reported in adult and pediatric populations of Pakistan. However, data describing the effect of MDR microbes on the gut microbiota is scarce. We designed a cross-sectional pediatric study to investigate the effect of MDR microbes' infection on the gut microbiome and its resistome of children using high-throughput next-generation sequencing (NGS). A cross-sectional study was conducted at a tertiary health care hospital in Peshawar Pakistan, between 5 September 2019 to 15 February...
Source: Libyan Journal of Medicine - April 20, 2021 Category: General Medicine Authors: Ome Kalsoom Afridi Johar Ali Jeong Ho Chang Source Type: research

Prodromal Phase of Hemolytic Uremic Syndrome Related to Shiga Toxin–Producing Escherichia coli: The Wasted Time
Conclusions During the diarrheal phase, 57% of patients consulted; three-quarters of them consulted to the pediatric emergency department. Shiga toxin–producing E. coli detection was poor, antibiotic use remained high, and anticipatory volume expansion was underused. These findings outline the critical need to improve the early management of STEC-HUS.
Source: Pediatric Emergency Care - October 1, 2021 Category: Emergency Medicine Tags: Original Articles Source Type: research

High prevalence of multidrug-resistant gram-negative bacterial infection following pediatric liver transplantation
This study has highlighted the high prevalence rate of MDR-GNB infection after pediatric LT. Therefore, caution on the emergence of MDR-GNB infection should be paid in at-risk children. Moreover, knowledge regarding the prevalence of MDR-GNB infection and resistant patterns is essential for guideline development to prevent and minimize the risk of MDR-GNB infection in this group of patients.
Source: Medicine - November 6, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Proctoclysis for rehydration in children - A scoping review and a pilot survey among medical doctors
Complement Ther Med. 2022 Nov 15:102902. doi: 10.1016/j.ctim.2022.102902. Online ahead of print.ABSTRACTAlthough proctoclysis (enema) is a historically proven, safe and cost-effective rehydration method that needs little training for users and can effectively replace intravenous hydration in different care settings, it is an uncommon choice for hydration in children with fever and is often missing in official guidelines. To evaluate the usefulness of proctoclysis, this study provides a scoping review of the existing literature. The matched literature was labelled in 5 categories, identifying 6 indication fields that are em...
Source: Complementary Therapies in Medicine - November 18, 2022 Category: Complementary Medicine Authors: Sz őke Henrik Sz őke Janka Martin David Jan Vagedes Kiss Ágnes Kov ács Zoltán Dobrylovsky Adam Mussler Odilia Kisbenedek Andrea Verz ár Zsófia Sz őke Rebeka Source Type: research

Evaluating the Impact of Clinical Decision Tools in Pediatric Acute Gastroenteritis: A Population‐based Cohort Study
ConclusionsAdmissions in children with AGE are not associated with the presence of clinical decision tools. While ORT medical directives are associated with lower ED revisits, printed discharge instructions have the opposite effect. The simple presence/absence of decision support tools does not guarantee improved clinical outcomes.This article is protected by copyright. All rights reserved.
Source: Academic Emergency Medicine - January 29, 2016 Category: Emergency Medicine Authors: Allison Bahm, Stephen B. Freedman, Jun Guan, Astrid Guttmann Tags: Original Contribution Source Type: research