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Infectious Disease: Gastroenteritis

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Cutaneous Burn Injury Modulates Urinary Antimicrobial Peptide Responses and the Urinary Microbiome
Conclusions: Our data reveal potential links for urinary tract infection development and several morbidities in burn patients through alterations in the urinary microbiome and antimicrobial peptides. Overall, this study supports the concept that early assessment of urinary antimicrobial peptide responses and the bacterial microbiome may be used to predict susceptibility to urinary tract infections and sepsis in burn patients.
Source: Critical Care Medicine - May 17, 2017 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Impact of Percutaneous Drainage on Outcome of Intra-abdominal Infection Associated With Pediatric Perforated Appendicitis
Conclusions: Children with perforated appendicitis and IAI often have a complicated and prolonged clinical course. Medical management consisting solely of parenteral antibiotic therapy is frequently ineffective in resolving IAI. Rapid clinical improvement commonly follows PD.
Source: The Pediatric Infectious Disease Journal - September 19, 2017 Category: Infectious Diseases Tags: Original Studies Source Type: research

Surfaceskins Excrete Alcohol on Every Push to Prevent Spread of In-Hospital Infections
Hospital acquired infections continue to be a major source of patient morbidities. Hand washing guidelines, ubiquitously available alcohol sanitizers, and keeping patients away from each other has helped reduce the spread of nosocomial infections. Ne...
Source: Medgadget - October 10, 2017 Category: Medical Devices Authors: Editors Tags: Critical Care Medicine Public Health Source Type: blogs

Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic Acute Kidney Injury
Conclusions: In septic acute kidney injury, renal medullary and urinary hypoxia developed several hours before increases in currently used biomarkers. Angiotensin II transiently improved renal function without worsening medullary hypoxia. In septic acute kidney injury, angiotensin II appears to be a safe, effective therapy, and urinary PO2 may be used to detect medullary hypoxia.
Source: Critical Care Medicine - December 19, 2017 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms
Conclusions Ondansetron does not affect the QTc of pediatric patients receiving the medication for nausea, vomiting, or inability to take fluids in the emergency department. No changes in the QTc are clinically significant. To date, there have been no studies evaluating the effect of ondansetron in this acutely ill population; therefore, a larger study should be completed to confirm these data.
Source: Pediatric Emergency Care - January 1, 2018 Category: Emergency Medicine Tags: Original Articles Source Type: research

Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome*
Conclusions: Mesenchymal stem cells from different sources led to variable responses in lungs and distal organs. Bone marrow and adipose tissue mesenchymal stem cells yielded greater beneficial effects than lung tissue mesenchymal stem cells. These findings may be regarded as promising in clinical trials.
Source: Critical Care Medicine - January 17, 2018 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms
Conclusions Ondansetron does not affect the QTc of pediatric patients receiving the medication for nausea, vomiting, or inability to take fluids in the emergency department. No changes in the QTc are clinically significant. To date, there have been no studies evaluating the effect of ondansetron in this acutely ill population; therefore, a larger study should be completed to confirm these data.
Source: Pediatric Emergency Care - January 1, 2018 Category: Emergency Medicine Tags: Original Articles Source Type: research

Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome*
Conclusions: Mesenchymal stem cells from different sources led to variable responses in lungs and distal organs. Bone marrow and adipose tissue mesenchymal stem cells yielded greater beneficial effects than lung tissue mesenchymal stem cells. These findings may be regarded as promising in clinical trials.
Source: Critical Care Medicine - January 17, 2018 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Clinical characteristics and antibiotic resistance pattern of pathogens in pediatric urinary tract infection.
CLINICAL CHARACTERISTICS AND ANTIBIOTIC RESISTANCE PATTERN OF PATHOGENS IN PEDIATRIC URINARY TRACT INFECTION. Southeast Asian J Trop Med Public Health. 2016 Sep;47(5):976-82 Authors: Amornchaicharoensuk Y Abstract Medical records of children less than 15-years of age admitted to hospital for urinary tract infection (UTI) from January 2010 to December 2014 were reviewed. Among 100 children (59% males and 41% females) with upper UTI, the most common pathogen (88%) was Escherichia coli, of which 69% were nonextended spectrum beta-lactamase (ESBL) and 19 % ESBL producers. Resistance to ampicillin and trime...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - April 8, 2018 Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research

Biological Response to Time-Controlled Adaptive Ventilation Depends on Acute Respiratory Distress Syndrome Etiology*
Conclusion: In pulmonary acute respiratory distress syndrome, time-controlled adaptive ventilation led to more pronounced beneficial effects on expression of biomarkers related to overdistension and extracellular matrix homeostasis.
Source: Critical Care Medicine - May 17, 2018 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis
Conclusions: Inhibition of E. coli binding to endothelial cell αVβ3 by cilengitide prevents endothelial dysfunction and may, therefore, present as a novel early therapeutic for the treatment of sepsis.
Source: Critical Care Medicine - July 14, 2018 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury
Objectives: To examine the effects of fluid bolus therapy on systemic hemodynamics, renal blood flow, intrarenal perfusion and oxygenation, PO2, renal function, and fluid balance in experimental early septic acute kidney injury. Design: Interventional study. Setting: Research institute. Subjects: Adult Merino ewes. Interventions: Implantation of flow probes on the pulmonary and renal arteries and laser Doppler oxygen-sensing probes in the renal cortex, medulla, and within a bladder catheter in sheep. Infusion of Escherichia coli to induce septic acute kidney injury (n = 8). After 24, 25, and 26 hours of sepsi...
Source: Critical Care Medicine - December 18, 2018 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Detecting Early Markers of Ventilator-Associated Pneumonia by Analysis of Exhaled Gas
Conclusions: This is the first in vivo study that shows the potential of gas chromatography-ion mobility spectrometry for early detection of ventilator-associated pneumonia specific volatile organic compounds and species differentiation by noninvasive analyses of exhaled gas.
Source: Critical Care Medicine - February 16, 2019 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Surveillance of multidrug-resistant bacteria in pediatric and neonatal intensive care units in Rio de Janeiro State, Brazil
CONCLUSIONS MDR Gram-negative bacteria (ESBL producers and carbapenem-resistant bacteria) were the most reported agents among MDR bacteria reported to Rio de Janeiro surveillance system. Except for CLABSI in children, they caused all device-associated infections in NICUs and PICUs.
Source: Revista da Sociedade Brasileira de Medicina Tropical - September 6, 2019 Category: Tropical Medicine Source Type: research

Is Intussusception a Middle-of-the-Night Emergency?
Objectives Intussusception is the most common abdominal emergency in pediatric patients aged 6 months to 3 years. There is often a delay in diagnosis, as the presentation can be confused for viral gastroenteritis. Given this scenario, we questioned the practice of performing emergency reductions in children during the night when minimal support staff are available. Pneumatic reduction is not a benign procedure, with the most significant risk being bowel perforation. We performed this analysis to determine whether it would be safe to delay reduction in these patients until normal working hours when more support staff are ...
Source: Pediatric Emergency Care - October 1, 2019 Category: Emergency Medicine Tags: Original Articles Source Type: research