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Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research

Prediction of herpes virus infections after solid organ transplantation: a prospective study of immune function
CONCLUSION: In conclusion, the incidence of positive herpes virus PCR tests was high, and a risk model including immune function allowed the prediction of positive herpes virus PCR and may be used to identify recipients at higher risk.PMID:37465673 | PMC:PMC10351284 | DOI:10.3389/fimmu.2023.1183703
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: Dina Leth M øller S øren Schwartz Sørensen Omid Rezahosseini Daniel Br äuner Rasmussen Nicoline Stender Arentoft Josefine Amalie Loft Michael Perch Finn Gustafsson Jens Lundgren Thomas Scheike Jenny Dahl Knudsen Sisse Rye Ostrowski Allan Rasmussen Sus Source Type: research

Investigating the relationship between the number and activity of natural killer cells with increased cytomegalovirus and CMV disease after kidney transplantation
We examined the association of the relationship between the number and activity of natural killer cells with increased cytomegalovirus and its related disease after kidney transplantation.MATERIAL AND METHODS: In this analytical study, 58 new transplant patients in the Labbafinejad Hospital, who did not have any evidence of CMV infection, were evaluated based on the number and percentage of CD56+/16+, CD56+/16-, and CD69+ Natural Killer (NK) cells.RESULTS: The results of this study showed that CD16+ and CD56+ cells in the group of CMV Ag-positive patients are less than negative patients (p = 0.003) and the difference betwe...
Source: Transplant Immunology - July 14, 2023 Category: Transplant Surgery Authors: Reza Asadzadeh Mohsen Nafar Pedram Ahmadpoor Shiva Samavat Hassan Nikoueinejad Morteza Hosseinzadeh Nahid Mamizadeh Saeideh Hatami Aliakbar Amirzargar Source Type: research

Avascular Necrosis in Renal Transplant Patients
CONCLUSIONS: We found that avascular necrosis appears most frequently in the first 2 years after kidney transplant and the most important risk factors are cumulative steroid dose and cytomegalovirus disease. In the follow-up of kidney transplant patients, it is important to use low-dose steroid doses if possible. Of note, preventing the development of cytomegalovirus disease by screening and prophylaxis for cytomegalovirus is also important in reducing the development of avascular necrosis.PMID:37074005 | DOI:10.6002/ect.2022.0345
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 19, 2023 Category: Transplant Surgery Authors: Bulent Kaya Saime Paydas Mustafa Balal Burak Mete Tolga Kuzu Source Type: research

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