Filtered By:
Source: Journal of Neurochemistry
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 123 results found since Jan 2013.
Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke
In conclusion, ML351 and tPA combination therapy is beneficial in ameliorating HT afte r ischemic stroke. This protective effect is probably because of 12/15‐LOX inhibition and suppression of JNK‐mediated microglia/macrophage activation.
Source: Journal of Neurochemistry - February 5, 2021 Category: Neuroscience Authors: Guangsen Cheng,
Wei Zhao,
Yongjie Xin,
Guomin Huang,
Yongkang Liu,
Zhongliang Li,
Meixiao Zhan,
Yong Li,
Ligong Lu,
Klaus Leyen,
Yu Liu Tags: ORIGINAL ARTICLE Source Type: research
Hyaluronidase inhibition accelerates functional recovery from stroke in the mouse brain
Hyaluronic acid (HA) is the main component of the brain extracellular matrix (ECM). During stroke, a massive breakdown of HA occurs (including perineuronal net ‐associated HA), however, the mechanism of this phenomenon remains unclear. We hypothesized that stroke up‐regulates the expression of HA metabolism‐associated enzymes and increases HA synthesis/degradation. We observed increased expression of HA‐degrading hyaluronidases and hexosaminidases, as well as HA synthases. Immunofluorescence studies revealed predominating astrocytic origin of the enzymes. Moreover, we found that inhibiting hyaluronidases with Vcpal...
Source: Journal of Neurochemistry - January 5, 2021 Category: Neuroscience Authors: Anna Katarzyna Greda,
Dorota Nowicka Tags: ORIGINAL ARTICLE Source Type: research
Activation of Neuronal Ras ‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
AbstractLong ‐term disability after stroke is common but the mechanisms of post‐stroke recovery is unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent roles in individual cell types after central neural system injury, we herein examined the specific role of neuronal Rac1 in post‐stroke recovery and axonal regeneration. Young male mice were subjected to 60‐minutes middle cerebral artery occlusion (MCAO). Inducible deletion of neuronal Rac1 by daily intraperitoneal injection of tamoxifen (2 mg/4 0 g) into Thy1...
Source: Journal of Neurochemistry - September 21, 2020 Category: Neuroscience Authors: Fan Bu,
Yashasvee Munshi,
J Weldon Furr,
Jia ‐wei Min,
Li Qi,
Anthony Patrizz,
Zachary R. Spahr,
Akihiko Urayama,
Julia K. Kofler,
Louise D. McCullough,
Jun Li Tags: ORIGINAL ARTICLE Source Type: research
Metabolic determinants of leukocyte pathogenicity in neurological diseases
AbstractNeuroinflammatory and neurodegenerative diseases are characterised by the recruitment of circulating blood ‐borne innate and adaptive immune cells into the central nervous system (CNS). These leukocytes sustain the detrimental response in the CNS by releasing pro‐inflammatory mediators that induce activation of local glial cells, blood‐brain barrier (BBB) dysfunction and neural cell death. However, infiltrating peripheral immune cells could also dampen CNS inflammation and support tissue repair. Recent advances in the field of immunometabolism demonstrate the importance of metabolic reprogramming for the acti...
Source: Journal of Neurochemistry - September 2, 2020 Category: Neuroscience Authors: Marah C. Runtsch,
Giovanni Ferrara,
Stefano Angiari Tags: REVIEW Source Type: research
Acute motor deficit and subsequent remyelination ‐associated recovery following internal capsule demyelination in mice
ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by accumulated motor disability. However, whether remyelination promotes motor recovery following demyelinating injury remains unclear. Damage to the internal capsule (IC) is known to result in motor impairment in MS and stroke. Here, we induced focal IC demyelination in mice by lysophosphatidylcholine (LPC) injection, and examined its effect on motor behavior. We also compared the effect of LPC induced IC damage to that produced by endothelin ‐1 (ET1), a potent vasoconstrictor used in experi...
Source: Journal of Neurochemistry - August 3, 2020 Category: Neuroscience Authors: Reiji Yamazaki,
Nobuhiko Ohno,
Jeffrey K. Huang Tags: ORIGINAL ARTICLE Source Type: research
Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
AbstractIntracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for ischemic stroke, which occurs as a consequence of endothelial cell death at the blood brain barrier (BBB) during thrombolytic reperfusion. We have previously shown that cerebral ischemia induced rapid occludin degradation and BBB disruption. Here we demonstrated an important role of occludin degradation in facilitating the evolution of ischemic endothelial cells towards death. Cultured brain microvascular endothelial cells (bEnd.3 cells) were exposed to oxygen ‐glucose deprivation (OGD) or incubated with occludin siRNA or ...
Source: Journal of Neurochemistry - June 11, 2020 Category: Neuroscience Authors: Yuan Zhang,
Xiaofeng Li,
Shanshan Qiao,
Dexin Yang,
Zongyang Li,
Ji Xu,
Weiping Li,
Li Su,
Wenlan Liu Tags: ORIGINAL ARTICLE Source Type: research
Differential mechanisms of tolerance induced by NMDA and 3,5 ‐dihydroxyphenylglycine (DHPG) preconditioning
In conclusion, preconditioning with NMDA or DHPG promotes differential neuroprotective mechanisms: NMDA by internalization of GluA1‐AMPA receptors, DHPG by producing the endocannabinoid 2‐AG.
Source: Journal of Neurochemistry - May 17, 2020 Category: Neuroscience Authors: Elisabetta Gerace,
Elisa Zianni,
Elisa Landucci,
Tania Scartabelli,
Rolando Berlinguer Palmini,
Daniela Iezzi,
Flavio Moroni,
Monica Di Luca,
Guido Mannaioni,
Fabrizio Gardoni,
Domenico E. Pellegrini ‐Giampietro Tags: ORIGINAL ARTICLE Source Type: research
HDAC2 (Histone deacetylase 2): a critical factor in environmental enrichment ‐mediated stroke recovery
In this study, focal stroke was induced by photothrombosis in male mice exposing to EE or standard housing (SH) conditions. Recombinant virus vectors, including Ad‐HDAC2‐Flag, AAV‐CAG‐EGFP‐Cre, LV‐shHDAC2 or their controls were microinjected into the motor co rtex at 3 d before stroke. Grid‐walking and cylinder tasks were conducted to assess motor function. Western blot and immunostaining were used to uncover the mechanisms underlying EE‐mediated stroke recovery. We found that EE exposure reversed stroke‐induced HDAC2 upregulation, implicating HDAC 2 in EE‐mediated functional recovery. Importantly, EE...
Source: Journal of Neurochemistry - May 15, 2020 Category: Neuroscience Authors: Yu ‐Hui Lin,
Meng‐Cheng Yao,
Hai‐Yin Wu,
Jian Dong,
Huan‐Yu Ni,
Xiao‐Lin Kou,
Lei Chang,
Chun‐Xia Luo,
Dong‐Ya Zhu Tags: ORIGINAL ARTICLE Source Type: research
Pannexin ‐1 in the CNS: emerging concepts in health and disease
AbstractPannexin ‐1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non‐selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well‐characterized with implications in purine signalling across a v ariety of biological contexts. Panx1 activity is also important in inflammasome formation and the secretion of pro‐inflammatory molecules such as interleukin‐1β. Within the central nervous system (CNS), Panx1 is expressed on both neurons and glia, and is thought to mediate crosstalk between the se cells. A...
Source: Journal of Neurochemistry - March 14, 2020 Category: Neuroscience Authors: Albert K. Yeung,
Chetan S. Patil,
Michael F. Jackson Tags: REVIEW ARTICLE Source Type: research
Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
AbstractMitochondrial dysfunction has a recognised role in the progression of Alzheimer's disease (AD) pathophysiology. Cerebral perfusion becomes increasingly inefficient throughout ageing, leading to unbalanced mitochondrial dynamics. This effect is exaggerated by amyloid β (Aβ) and phosphorylated tau, two hallmark proteins of AD pathology. A neuroprotective role for the adipose‐derived hormone, leptin, has been demonstrated in neuronal cells. However, its effects with relation to mitochondrial function in AD remain largely unknown. To address this question, we h ave used both a glucose‐serum deprived (CGSD) model ...
Source: Journal of Neurochemistry - March 13, 2020 Category: Neuroscience Authors: Ying Cheng,
Matthew Buchan,
Karina Vitanova,
Laura Aitken,
Frank J Gunn ‐Moore,
Rona R. Ramsay,
Gayle Doherty Tags: ORIGINAL ARTICLE Source Type: research
Complex Sex and Estrous Cycle Differences in Spontaneous Transient Adenosine
AbstractAdenosine is a ubiquitous neuromodulator that plays a role in sleep, vasodilation, and immune response and manipulating the adenosine system could be therapeutic for Parkinson ’s disease or ischemic stroke. Spontaneous transient adenosine release provides rapid neuromodulation; however, little is known about the effect of sex as a biological variable on adenosine signaling and this is vital information for designing therapeutics. Here, we investigate sex differences in spontaneous, transient adenosine release using fast‐scan cyclic voltammetry to measure adenosinein vivo in the hippocampus CA1, basolateral amyg...
Source: Journal of Neurochemistry - February 10, 2020 Category: Neuroscience Authors: Jason R. Borgus,
Pumidech Puthongkham,
B. Jill Venton Tags: ORIGINAL ARTICLE Source Type: research
Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation
AbstractBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor ‐independent mechanism by reversing the reaction catalysed by S‐adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S‐adenosylmethionine (SAM)‐dependent methyltransferases. Astrocytes are essential in maintaining brain homeostasis but their pathological activa tion and uncontrolled proliferation plays a role in neurodegeneration and glioma. Adenosine can affect cell proliferatio...
Source: Journal of Neurochemistry - December 6, 2019 Category: Neuroscience Authors: Helena Marcelino,
Vanda C. Nogueira,
Cec ília R.A. Santos,
Patrícia Quelhas,
Tiago M.A. Carvalho,
João Fonseca‐Gomes,
Joana Tomás,
Maria J. Diógenes,
Ana M. Sebastião,
José F. Cascalheira Tags: ORIGINAL ARTICLE Source Type: research
Down ‐regulation of miR‐3068‐3p enhances kcnip4‐regulated A‐type potassium current to protect against glutamate‐induced excitotoxicity
AbstractThe main cause of excitotoxic neuronal death in ischemic stroke is the massive release of glutamate. Recently, microRNAs (miRNAs) have been found to play an essential role in stroke pathology, although the molecular mechanisms remain to be investigated. Here, to identify potential candidate miRNAs involved in excitotoxicity, we treated rat primary cortical neurons with glutamate and found that miR ‐3068‐3p, a novel miRNA, was upregulated. We hypothesized that restoring miR‐3068‐3p expression might influence the neuronal injury outcomes. The inhibition of miR‐3068‐3p, using tough decoy lentiviruses, sign...
Source: Journal of Neurochemistry - December 1, 2019 Category: Neuroscience Authors: Zi ‐Jun Su,
Xu‐Yi Wang,
Chen Zhou,
Zhen Chai Tags: ORIGINAL ARTICLE Source Type: research
