Complex Sex and Estrous Cycle Differences in Spontaneous Transient Adenosine

AbstractAdenosine is a ubiquitous neuromodulator that plays a role in sleep, vasodilation, and immune response and manipulating the adenosine system could be therapeutic for Parkinson ’s disease or ischemic stroke. Spontaneous transient adenosine release provides rapid neuromodulation; however, little is known about the effect of sex as a biological variable on adenosine signaling and this is vital information for designing therapeutics. Here, we investigate sex differences in spontaneous, transient adenosine release using fastā€scan cyclic voltammetry to measure adenosinein vivo in the hippocampus CA1, basolateral amygdala, and prefrontal cortex. The frequency and concentration of transient adenosine release were compared by sex and brain region, and in females, stage of estrous. Females had larger concentration transients in the hippocampus (0.161 ±0.003 µM) and the amygdala (0.182±0.006 µM) than males (hippocampus: 0.134 ±0.003, amygdala: 0.115±0.002 µM), but the males had a higher frequency of events. In the prefrontal cortex, the trends were reversed. Males had higher concentrations (0.189±0.003 µM) than females (0.170±0.002 µM) , but females had higher frequencies. Examining stages of the estrous cycle, in the hippocampus, adenosine transients are higher concentration during proestrus and diestrus. In the cortex, adenosine transients were higher concentration during proestrus, but were lower ...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Source: Dimensions in Critical Care Nursing - Category: Nursing Tags: Dimens Crit Care Nurs Source Type: research
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Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Neurology - Category: Neurology Authors: Tags: All Cerebrovascular disease/Stroke, All Sleep Disorders, Cohort studies ARTICLE Source Type: research
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Source: Neurology - Category: Neurology Authors: Tags: Neuroepidemiology: Cerebrovascular Disease I Source Type: research
FIGHT AGING! NEWSLETTER June 13th 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to on...
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