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Total 3067 results found since Jan 2013.
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. Therefore, we used semaglutide, a novel GLP-1R agonist currently undergoing two phase 3 clinical trials in AD patients, to observe the effect of SIRT1 after semaglutide treatment in 3XTg mice and HT22 cells, and to explore the mechanism of SIRT1 in the glucose metabolism disorders of AD. The mice were injected with semaglutide on alternate days for 30 days, followed by behavioral experiments including open field test, new object recognition test, and Y-maze. The content of glucose in the brain was also measured by usi...
Source: Neuropharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Zhao-Jun Wang Xin-Ru Li Shi-Fan Chai Wei-Ran Li Shuo Li Meng Hou Jia-Lei Li Yu-Cai Ye Hong-Yan Cai Christian H ölscher Mei-Na Wu Source Type: research
PET/CT-based deep learning grading signature to optimize surgical decisions for clinical stage I invasive lung adenocarcinoma and biologic basis under its prediction: a multicenter study
CONCLUSION: The DLGS harbors the potential to predict the histologic grade and personalize the surgical treatments for clinical stage I invasive lung adenocarcinoma. Its applicability to other territories should be further validated by a larger international study.PMID:37725128 | DOI:10.1007/s00259-023-06434-7
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Yifan Zhong Chuang Cai Tao Chen Hao Gui Cheng Chen Jiajun Deng Minglei Yang Bentong Yu Yongxiang Song Tingting Wang Yangchun Chen Huazheng Shi Dong Xie Chang Chen Yunlang She Source Type: research
Point-of-care AI-assisted stepwise ultrasound pneumothorax diagnosis
Phys Med Biol. 2023 Sep 19. doi: 10.1088/1361-6560/acfb70. Online ahead of print.ABSTRACTUltrasound is extensively utilized as a convenient and costeffective method in emergency situations. Unfortunately, the limited availability of skilled clinicians in emergency hinders the wider adoption of point-of-care ultrasound. To overcome this challenge, this paper aims to aid less experienced healthcare providers in emergency lung ultrasound scans.
Approach: To assist healthcare providers, it is important to have a comprehensive model that can automatically guide the entire process of lung ultrasound based on the clinicia...
Source: Physics in Medicine and Biology - September 19, 2023 Category: Physics Authors: Kyungsang Kim Fabiola Macruz Dufan Wu Christopher Bridge Suzannah McKinney Ahad Alhassan Al Saud Elshaimaa Sharaf Adam Pely Paul Danset Tom Duffy Davin Dhatt Varun Buch Andrew Liteplo Quanzheng Li Source Type: research
Aortic Annulus Detection Based on Deep Learning for Transcatheter Aortic Valve Replacement Using Cardiac Computed Tomography
CONCLUSION: Our deep learning framework was feasible to detect the 3D complex structure of the aortic annulus plane using cardiac CT for TAVR. The performance of our algorithms was higher than other convolutional neural networks.PMID:37724499 | DOI:10.3346/jkms.2023.38.e306
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Yongwon Cho Soojung Park Sung Ho Hwang Minseok Ko Do-Sun Lim Cheol Woong Yu Seong-Mi Park Mi-Na Kim Yu-Whan Oh Guang Yang Source Type: research
Point-of-care AI-assisted stepwise ultrasound pneumothorax diagnosis
Phys Med Biol. 2023 Sep 19. doi: 10.1088/1361-6560/acfb70. Online ahead of print.ABSTRACTUltrasound is extensively utilized as a convenient and costeffective method in emergency situations. Unfortunately, the limited availability of skilled clinicians in emergency hinders the wider adoption of point-of-care ultrasound. To overcome this challenge, this paper aims to aid less experienced healthcare providers in emergency lung ultrasound scans.
Approach: To assist healthcare providers, it is important to have a comprehensive model that can automatically guide the entire process of lung ultrasound based on the clinicia...
Source: Physics in Medicine and Biology - September 19, 2023 Category: Physics Authors: Kyungsang Kim Fabiola Macruz Dufan Wu Christopher Bridge Suzannah McKinney Ahad Alhassan Al Saud Elshaimaa Sharaf Adam Pely Paul Danset Tom Duffy Davin Dhatt Varun Buch Andrew Liteplo Quanzheng Li Source Type: research
Aortic Annulus Detection Based on Deep Learning for Transcatheter Aortic Valve Replacement Using Cardiac Computed Tomography
CONCLUSION: Our deep learning framework was feasible to detect the 3D complex structure of the aortic annulus plane using cardiac CT for TAVR. The performance of our algorithms was higher than other convolutional neural networks.PMID:37724499 | PMC:PMC10506901 | DOI:10.3346/jkms.2023.38.e306
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Yongwon Cho Soojung Park Sung Ho Hwang Minseok Ko Do-Sun Lim Cheol Woong Yu Seong-Mi Park Mi-Na Kim Yu-Whan Oh Guang Yang Source Type: research
Residential overcrowding in relation to children's health, environment and schooling - a qualitative study
CONCLUSIONS: Our qualitative evidence suggest that overcrowding has a negative impact on children's health, environment and schooling.PMID:37723969 | DOI:10.1177/14034948231198285
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Johnny C Lorentzen Antonios Georgellis Maria Albin Marina Jonsson Source Type: research
Analysis and prediction of liver volume change maps derived from computational tomography scans acquired pre- and post-radiation therapy
This study leverages the use of deep learning-based segmentation and biomechanical deformable image registration (DIR) to analyze and predict this relationship. Pre- and Post-EBRT imaging data were collected for 100 patients treated for HCC, CC or CRC with IMRT with prescription doses ranging from 50 to 100 Gy delivered in 10 to 28 fractions. For each patient, DIR between the portal and venous (PV) phase of a diagnostic CT scan acquired before RT planning, and a PV phase of a diagnostic CT scan acquired after the end of RT (on average 147±36 days) was performed to calculate Jacobian maps representing volume changes in the...
Source: Physics in Medicine and Biology - September 15, 2023 Category: Physics Authors: Guillaume Cazoulat Aashish C Gupta Mais M Al Taie Eugene J Koay Kristy K Brock Source Type: research
Clinical Trainee Perspectives on the Implementation of Trauma-Focused Training
CONCLUSIONS: Effective implementation of trauma-specific psychotherapy training should be guided by ongoing dialogue between trainees and training stakeholders.PMID:37703116 | DOI:10.1176/appi.psychotherapy.20220047
Source: American Journal of Psychotherapy - September 13, 2023 Category: Psychiatry & Psychology Authors: Luciano G Dolcini-Catania Shana E DeVlieger Jill M Cyranowski Source Type: research
