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ASL and susceptibility-weighted imaging contribution to the management of acute ischaemic stroke
AbstractMagnetic resonance imaging (MRI) plays a central role in the early diagnosis of cerebral vascular events. Today, MRI is used not only for the detection of acute ischaemic lesions, but also to fine tune the diagnosis and improve patient selection for early therapeutic decision-making. In this perspective, new tools such as arterial spin labelling (ASL) and susceptibility-weighted imaging (SWI) sequences have been developed. These MRI sequences enable noninvasive assessment of brain damage, providing important diagnostic and prognostic information: evaluation of cerebral parenchymal perfusion; detection and aetiologi...
Source: Insights into Imaging - November 6, 2016 Category: Radiology Source Type: research

E-176 Endovascular stent retriever thrombectomy of medium and small vessel occlusion of the middle cerebral artery with acute ischemic stroke: a case series
ConclusionsOur case series demonstrated that SRMT in SVO with disabling NIHSS is feasible and safe if performed carefully. All patient achieved TICI 3 perfusion and first pass effect was better observed in trap technique and use of long solitaire STD. Good function outcomes were achieved in all cases irrespective of the types of SRD used and passes required to achieve TICI 3 perfusion. Further studies are required.Disclosures Y. Lodi: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lodi, Y. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Blood pressure and cerebral ischemia: A continuing dilemma
Classical neurologic teaching suggests that a higher cerebral systemic blood pressure (BP) be targeted for individuals with occlusive carotid disease, in order to improve cerebral perfusion through collaterals. This conflicts, however, with observational, population-based studies and clinical trials supporting better outcomes associated with lower BPs. In this issue of Neurology®, Powers et al.1 evaluate nonsurgical controls from the Carotid Occlusion Surgery Study (COSS), and report lower rates of stroke recurrence in individuals maintained at a follow-up BP of 130/85 mm Hg or lower.
Source: Neurology - March 24, 2014 Category: Neurology Authors: Gottesman, R. F., Chalmers, J. Tags: All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Symptomatic Intracranial Atherosclerosis With Impaired Distal Perfusion Illustrative Teaching Cases
Source: Stroke - December 22, 2017 Category: Neurology Authors: Katarina Dakay, Shadi Yaghi Tags: Cerebrovascular Disease/Stroke Illustrative Teaching Case Source Type: research

Comparison of Levosimendan versus Dobutamine in Patients with Moderate to Severe Left Ventricular Dysfunction Undergoing Off-pump Coronary Artery Bypass Grafting: A Randomized Prospective Study.
CONCLUSIONS: Levosimendan was associated with statistically significant increase in indices of contractility (CI, LVSWI, and RVSWI) and decrease in PCWP during and after OPCAB. Levosimendan group had lower incidence of atrial fibrillation, shorter length of ICU, and hospital stay. PMID: 28393781 [PubMed - in process]
Source: Annals of Cardiac Anaesthesia - April 1, 2017 Category: Anesthesiology Authors: Kandasamy A, Simon HA, Murthy P, Annadurai M, Ali MM, Ramanathan G Tags: Ann Card Anaesth Source Type: research

Teaching NeuroImages: Perfusion imaging of cerebral hyperperfusion syndrome following revascularization
A 69-year-old man developed acute-onset confusion and hypertension with systolic pressures in the 160s 1 day after carotid endarterectomy for right facial droop from left hemispheric lacunar infarcts. CT perfusion (figure, A–D) demonstrated findings consistent with cerebral hyperperfusion syndrome (CHS) following revascularization. CHS is caused by loss of autoregulation, hypertension, and ischemia-reperfusion injury resulting in increased regional blood flow and vascular congestion.1 CHS following revascularization may present as ipsilateral headache, focal seizure, or neurologic deficit. Nonperfusion imaging may sh...
Source: Neurology - July 22, 2013 Category: Neurology Authors: Kalra, V. B., Rao, B., Malhotra, A. Tags: CT, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Proprietary Software Enhancement of Digital Subtraction Angiography for Perfusion Mapping of Posterior Circulation (P6.022)
Conclusion: AngioViz DSA enhancement technique may reliably identify patients with intra-procedural neurovascular perfusion deficits for posterior circulation when none exists. Further larger retrospective analysis and prospective validation studies for reproducibility and reliability of this software application are needed.Disclosure: Dr. Avignon has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Korya has nothing to disclose. Dr. Arango has nothing to disclose. Dr. Brar has nothing to disclose. Dr. Moussavi has nothing to disclose. Dr. Kirmani has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Avignon, G., Mehta, S., Korya, D., Arango, A., Brar, J., Moussavi, M., Kirmani, J. Tags: Ischemic Stroke Diagnosis Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Trauma & Triage Geriatric Teaching Moments from A.J. Heightman, MPA, EMT-P – JEMS Editor-in-Chief relative to the Texas Church Mini Bus Crash that Killed 13 Senior Citizens
When 13 senior citizens were killed in a horrible head-on collision between a San Antonio church mini bus and a pickup truck in southwest Texas, the AP story noted that the elderly occupants “were more susceptible to internal injuries and damage to vulnerable organs because of their advanced ages.” (see below as presented by the Associated Press). As an educator who spends a lot of time educating crews about the unique impact trauma can have on geriatric patients, I thought I would take the opportunity to present a few important facts about geriatric trauma and assessment tips to remember when you are tasked with triag...
Source: JEMS Patient Care - April 2, 2017 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT P Tags: Major Incidents News Category Orientation Patient Care Source Type: news

Effects of Normothermic Machine Perfusion Conditions on Mesenchymal Stromal Cells
In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research