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Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus.
CONCLUSIONS: Tight blood sugar control reduces the risk of developing microvascular diabetes complications. The evidence of benefit is mainly from studies in younger patients at early stages of the disease. Benefits need to be weighed against risks including severe hypoglycaemia, and patient training is an important aspect in practice. The effects of tight blood sugar control seem to become weaker once complications have been manifested. However, further research is needed on this issue. Furthermore, there is a lack of evidence from RCTs on the effects of tight blood sugar control in older patient populations or patients w...
Source: Cochrane Database of Systematic Reviews - February 14, 2014 Category: Journals (General) Authors: Fullerton B, Jeitler K, Seitz M, Horvath K, Berghold A, Siebenhofer A Tags: Cochrane Database Syst Rev Source Type: research

HMG CoA reductase inhibitors (statins) for kidney transplant recipients.
CONCLUSIONS: Statins may reduce cardiovascular events in kidney transplant recipients, although treatment effects are imprecise. Statin treatment has uncertain effects on overall mortality, stroke, kidney function, and toxicity outcomes in kidney transplant recipients. Additional studies would improve our confidence in the treatment benefits and harms of statins on cardiovascular events in this clinical setting. PMID: 24470059 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 3, 2014 Category: Journals (General) Authors: Palmer SC, Navaneethan SD, Craig JC, Perkovic V, Johnson DW, Nigwekar SU, Hegbrant J, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

Hormone Therapy in Women After Heart Transplantation
Conclusions: HT is not associated with poor outcome or adverse effects in female heart transplant patients after age 35 years. However, a larger cohort of patients is necessary to confirm these observations.
Source: Transplantation Proceedings - November 1, 2013 Category: Transplant Surgery Authors: L.C. Kobashigawa, M. Hamilton, M. Rafiei, L. Stern, C.N. Bairey Merz Tags: Thoracic Transplantation Source Type: research

Survival after lung transplantation in systemic sclerosis. A systematic review
Conclusion: The short-term and intermediate-term survival post-lung transplantation are similar to IPAH and ILD patients requiring lung transplantation.
Source: Respiratory Medicine CME - October 9, 2013 Category: Respiratory Medicine Authors: Irfan Y. Khan, Lianne G. Singer, Marc de Perrot, John T. Granton, Shaf Keshavjee, Cathy Chau, Amie Kron, Sindhu R. Johnson Tags: Transplantation Source Type: research

Trigeminal sensory recovery using processed nerve allografts for large continuity defects
The processed nerve allograft, Avance (AxoGen, Alachua, FL), has become a popular alternative to an autograft for the repair of nerve injuries, including the trigeminal nerve. Clinical outcome data on their safety and effectiveness in restoring sensory function of the trigeminal nerve is needed. Sensory assessments of trigeminal nerve injuries were conducted at pre-surgical, 3, 6, and 12 months post-surgical reconstruction with Avance® Nerve Graft. Subjects with at least 6 months of follow-up were included in this analysis. Assessments included brush stroke directional sensation (BSDS), static 2-point discrimination (s2PD...
Source: International Journal of Oral and Maxillofacial Surgery - October 1, 2013 Category: ENT & OMF Authors: J. Zuniga Source Type: research

Effect of Reduced Sympathetic Hyperactivity on Cardiovascular Risk Factors in Kidney Transplantation Patients
Abstract: Background: Hyperactivity of the sympathetic nervous system caused by chronic kidney disease has detrimental effects on hypertension and cardiovascular morbidity. Kidney transplantation does not ameliorate sympathetic nerve overactivity; however, bilateral nephrectomy eliminates it. The aim of the study was to evaluate the effect of bilateral nephrectomy on risk factors for cardiovascular morbidity and mortality in long-term follow-up. Material and Methods: We studied 24 kidney recipients aged 44 ± 13 years who had undergone native bilateral nephrectomy. The control group included 17 recipients with preserve...
Source: Transplantation Proceedings - May 1, 2013 Category: Transplant Surgery Authors: M. Boratyńska, A.M. Zoń, M. Obremska, K. Pocza̧tek, M. Protasiewicz, M. Magott, M. Klinger Tags: Renal Transplantation Source Type: research

Primary Extracranial Vertebral Artery Aneurysms
Conclusions: Primary extracranial vertebral artery aneurysms are rare and occur in patients with hereditary disorders. Operative intervention is warranted in symptomatic patients. Exclusion and reconstruction may be performed with open and hybrid techniques with low morbidity and mortality.
Source: Annals of Vascular Surgery - March 27, 2013 Category: Surgery Authors: Mark D. Morasch, Sachin V. Phade, Peter Naughton, Manuel Garcia-Toca, Guillermo Escobar, Ramon Berguer Tags: Clinical Research Source Type: research

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