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Mediators of the Effect of obesity on Stroke and Heart Disease Risk: Decomposing Direct and Indirect Effects
CONCLUSIONS: High BMI in young adults increases the risk of metabolic mediators in their middle age, and metabolic mediators explain the adverse effects of high BMI on stroke risk than IHD risk.PMID:35781427 | DOI:10.2188/jea.JE20210476
Source: Journal of Epidemiology - July 5, 2022 Category: Epidemiology Authors: Yongho Jee Mikyung Ryu In Sun Ryou Joung Hwan Back Sung-Il Cho Seung Sik Hwang Source Type: research

Incidence and Severity of Intracerebral Hemorrhage on Oral Anticoagulation and Antiplatelet Therapy
This study aimed to assess the occurrence of intracerebral hemorrhage (ICH) in patients using OA or AP registered in the JOINVASC between 2015 and 2020. Higher mortality among OA or AP patients was seen, with a statistically significant difference in mortality within 90 days (38% versus 25%, p=0.025). For patients with OA at the time of ICH, high stroke severity was observed, with a 71% mortality rate. Managing bleeding episodes on OA and AP is key in the effort to prevent cardiovascular death and disability, and improved access to DOAC and reversal agents is in need for this patient population.
Source: Neuroepidemiology - June 27, 2022 Category: Epidemiology Source Type: research

Statin Therapy for Preventing Recurrent Stroke in Patients with Ischemic Stroke: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Observational Cohort Studies
We examined the outcomes of recurrent stroke (after ischemic stroke) of any type, and separately recurrent ischemic stroke and recurrent hemorrhagic stroke. RCTs and observational cohort studies were meta-analysed separately. Odds ratios (OR) was used to assess the effect of statin therapy. Meta-analysis was conducted using RevMan 5.4 software. Results We retrieved 559 papers in searches, of which 11 RCTs and 12 observational cohort studies were included. Both RCTs and observational studies found that statins reduced the odds of stroke of any type in those with an initial ischemic stroke (11 RCTs: OR=0.87, 95% CI [0.77,0....
Source: Neuroepidemiology - June 26, 2022 Category: Epidemiology Source Type: research

Hospitalisation rate and mortality among people with and without diabetes during the COVID-19 pandemic year 2020
AbstractMost studies reported reduced health care use among people with diabetes during the COVID-19 pandemic. This may be due to restricted medical services or people avoiding health care services because they fear being infected with COVID-19 in health care facilities. The aim of our study was to analyse hospitalisation and mortality in people with and without diabetes in Germany during the COVID-19 pandemic year 2020 compared to 2017 –2019. The data were sourced from a German statutory health insurance company covering 3.2 million people. We estimated age-sex standardised rates of mortality, all-cause hospitalisation,...
Source: European Journal of Epidemiology - June 8, 2022 Category: Epidemiology Source Type: research

Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study
CONCLUSIONS: Subject to the limitations of a non-randomized comparison, women with stroke due to LVO treated with mechanical thrombectomy had a better chance to achieve complete recanalization, and 3-month functional independence than men. The results could be driven by women who underwent combined treatment.PMID:35647312 | PMC:PMC9134778 | DOI:10.1177/23969873221091648
Source: Adv Data - June 1, 2022 Category: Epidemiology Authors: Ilaria Casetta Enrico Fainardi Giovanni Pracucci Valentina Saia Fabrizio Sallustio Valerio da Ros Sergio Nappini Patrizia Nencini Guido Bigliardi Sergio Vinci Francesco Grillo Sandra Bracco Rossana Tassi Mauro Bergui Paolo Cerrato Andrea Saletti Alessandr Source Type: research

Renal impairment and the prognosis of endovascular thrombectomy: a meta-analysis and systematic review
CONCLUSION: Our results suggest that in patients with AIS who underwent EVT, RI at admission was associated with 3-month poor functional outcome and mortality.PMID:35646161 | PMC:PMC9133867 | DOI:10.1177/17562864221083620
Source: Adv Data - June 1, 2022 Category: Epidemiology Authors: Rui Wang Zechun Xie Bo Li Peng Zhang Source Type: research

XaMINA: A Real-World, Prospective, Observational Study of Treatment-Na ïve Patients Treated with Rivaroxaban for Stroke Prevention in Atrial Fibrillation in Asia
CONCLUSION: XaMINA demonstrated low incidence rates of major bleeding events and thromboembolic events in patients with NVAF newly initiating rivaroxaban in South Korea and Taiwan, consistent with previous real-world studies reconfirming the results of the ROCKET AF study.TRIAL REGISTRATION: The trial was registered on ClinicalTrials.gov (identifier NCT03284762) on 15 September 2017.PMID:35616848 | DOI:10.1007/s12325-022-02102-8
Source: Adv Data - May 26, 2022 Category: Epidemiology Authors: Ping-Yen Liu Eue-Keun Choi Tae-Seok Kim Jen-Yuan Kuo Jung Myung Lee Young Keun On Sang-Weon Park Hyung-Wook Park Dong-Gu Shin Lili Wang Hsueh-Wei Yen Moon-Hyoung Lee XaMINA Investigators Source Type: research

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