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Specialty: Neurology
Education: Study
Therapy: Statin Therapy
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Total 244 results found since Jan 2013.
Cholesterol, Statins and the Risk of Dementia in the Oldest-Old: The 90+ Study (S58.003)
CONCLUSIONS: Contrary to studies reporting that high cholesterol is associated with decreased dementia in the oldest-old, we report that hypercholesterolemia was not associated with dementia while statin users were at decreased dementia risk. There are a variety of mechanisms by which statins may be neuroprotective including effects on amyloid production, neurofibrillary tangles, secondary stroke prevention, and other anti-inflammatory pleiotropic effects. Additional research is needed to explore other potential explanations for our results along with assessment of the effect of serum cholesterol levels and statin lipophil...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Evans, M., Kawas, C., Corrada, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research
Brain proteomics identifies possible simvastatin targets in acute phase of stroke in a rat embolic model
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - March 24, 2014 Category: Neurology Authors: Mireia Campos‐Martorell, Nelida Salvador, Marta Monge, Francesc Canals, Lidia García‐Bonilla, Mar Hernández‐Guillamon, María Irene Ayuso, Pilar Chacón, Anna Rosell, Alberto Alcazar, Joan Montaner Tags: Original Article Source Type: research
Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry
Conclusions:
In our region, Lombardia, adherence to guidelines in statin prescription at Stroke Unit discharge is very different from international goals. The presence of dyslipidemia remains the main factor influencing statin prescription, while the presence of well-defined atherosclerotic etiopathogenesis of stroke does not enhance statin prescription. Some uncertainties about the risk/benefit of statin therapy in stroke etiology subtypes (cardioembolism, other or undetermined causes) may partially justify the underuse of statin in ischemic stroke. The differences that exist between current international guidelines may p...
Source: BMC Neurology - March 21, 2014 Category: Neurology Authors: Canavero IsabellaCavallini AnnaPerrone PatriziaMagoni MauroSacchi LuciaQuaglini SilvanaLanzola GiordanoMicieli Giuseppe Source Type: research
Statin treatment in patients with acute ischemic stroke
ConclusionStatin treatment may improve the outcomes in patients with acute ischemic stroke. Further studies are necessary to confirm this finding.
Source: International Journal of Stroke - March 4, 2014 Category: Neurology Authors: Mohamed Al‐Khaled, Christine Matthis, Jürgen Eggers Tags: Research Source Type: research
C-Reactive Protein as a Prognostic Marker After Lacunar Stroke: Levels of Inflammatory Markers in the Treatment of Stroke Study Clinical Sciences
Conclusions—
Among recent lacunar stroke patients, hsCRP levels predict the risk of recurrent strokes and other vascular events. hsCRP did not predict the response to dual antiplatelets.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Elkind, M. S. V., Luna, J. M., McClure, L. A., Zhang, Y., Coffey, C. S., Roldan, A., Del Brutto, O. H., Pretell, E. J., Pettigrew, L. C., Meyer, B. C., Tapia, J., White, C., Benavente, O. R., on behalf of the LIMITS Investigators, The LIMITS Investigators Tags: Cerebrovascular disease/stroke, Cerebral Lacunes, Epidemiology Clinical Sciences Source Type: research
Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats
Conclusions: The present study demonstrates that rosuvastatin pretreatment ameliorates EBI after SAH through the attenuation of oxidative stress and NF-κB–mediated inflammation.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2014 Category: Neurology Authors: Ken Uekawa, Yu Hasegawa, Mingjie Ma, Takashi Nakagawa, Tetsuji Katayama, Daisuke Sueta, Kensuke Toyama, Keiichiro Kataoka, Nobutaka Koibuchi, Takayuki Kawano, Jun-ichi Kuratsu, Shokei Kim-Mitsuyama Tags: Original Articles Source Type: research
Lipoprotein-associated Phospholipase A2 during the Hyperacute Stage of Ischemic and Hemorrhagic Strokes
Conclusions: Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2014 Category: Neurology Authors: Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, Fouzi Mestari, Emeline Gillet, Sophie Crozier, Mélika Sahli-Amor, Yves Samson, Dominique Bonnefont-Rousselot, Randa Khani-Bittar Tags: Original Articles Source Type: research
Dose-Related Effects of Statins on Symptomatic Intracerebral Hemorrhage and Outcome After Thrombolysis for Ischemic Stroke Clinical Sciences
Conclusions—
We observed an association between increasing dose of statin use and risk of sICH after intravenous thrombolysis. Nevertheless, there was an overall beneficial effect of previous statin use on favorable 3-month outcome.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Scheitz, J. F., Seiffge, D. J., Tutuncu, S., Gensicke, H., Audebert, H. J., Bonati, L. H., Fiebach, J. B., Tranka, C., Lyrer, P. A., Endres, M., Engelter, S. T., Nolte, C. H. Tags: Other Treatment, Thrombolysis Clinical Sciences Source Type: research
Discharge Is a Critical Time to Influence 10-Year Use of Secondary Prevention Therapies for Stroke Clinical Sciences
Conclusions—
Prescription of medications at hospital discharge was the strongest predictor of ongoing medication use in survivors of stroke, even at 10 years after stroke. Ensuring that patients with stroke are discharged on optimal medications is likely to improve their long-term management, but further strategies might be required among those who are disadvantaged.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Thrift, A. G., Kim, J., Douzmanian, V., Gall, S. L., Arabshahi, S., Loh, M., Evans, R. G. Tags: Compliance/Adherence, Secondary prevention, Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research
Tissue kallikrein preventing the restenosis after stenting of symptomatic MCA atherosclerotic stenosis (KPRASS)
ConclusionAs our pilot study, tissue kallikrein would be expected to prevent the long‐term in‐stent restenosis after stenting of the symptomatic middle cerebral artery dramatically.
Source: International Journal of Stroke - December 21, 2013 Category: Neurology Authors: Wenya Lan, Fang Yang, Ling Liu, Qin Yin, Min Li, Zhuangli Li, Hongfei Sang, Gelin Xu, Minmin Ma, Zhizhong Zhang, Zhenguo Liu, Xinfeng Liu, Renliang Zhang Tags: Protocols Source Type: research
Differences in lipid profiles in two Hispanic ischemic stroke populations
ConclusionWe found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low‐density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race‐ethnic group and may lead to different secondary prevention strategies.
Source: International Journal of Stroke - December 20, 2013 Category: Neurology Authors: A. Arauz, J. G. Romano, A. Ruiz‐Franco, T. Shang, C. Dong, T. Rundek, S. Koch, B. Hernández‐Curiel, J. Pacheco, P. Rojas, F. Ruiz‐Navarro, M. Katsnelson, R. L. Sacco Tags: Research Source Type: research
Total cerebral blood flow and mortality in old age: A 12-year follow-up study
Conclusions:
Low total CBF is linked with higher risk of all-cause, noncardiovascular, and cardiovascular mortality in older people independent of clinical cardiovascular status.
Source: Neurology - November 25, 2013 Category: Neurology Authors: Sabayan, B., van der Grond, J., Westendorp, R. G., Jukema, J. W., Ford, I., Buckley, B. M., Sattar, N., van Osch, M. J. P., van Buchem, M. A., de Craen, A. J. M. Tags: MRI, All Cerebrovascular disease/Stroke, Cohort studies ARTICLE Source Type: research
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage Clinical Sciences
Conclusions—
Statin use does not seem to attenuate the association of HC with decreased risk for nonlobar ICH. Our data support a gene-by-drug effect for lobar ICH, but larger sample sizes are needed to confirm the association before any clinical change is warranted.
Clinical Trial Registration—
URL: http://clinicaltrials.gov. Unique identifier: NCT00930280.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Woo, D., Deka, R., Falcone, G. J., Flaherty, M. L., Haverbusch, M., Martini, S. R., Greenberg, S. M., Ayres, A. M., Sauerbeck, L., Kissela, B. M., Kleindorfer, D. O., Moomaw, C. J., Anderson, C. D., Broderick, J. P., Rosand, J., Langefeld, C. D., Woo, J. Tags: Embolic stroke Clinical Sciences Source Type: research
Metformin-inclusive Therapy Reduces the Risk of Stroke in Patients with Diabetes: A 4-Year Follow-up Study
Metformin is a kind of oral hypoglycemic agents commonly prescribed to patients with diabetes mellitus. Although past studies had proven its protective effect on cardiovascular risk and related mortality, the evidence of metformin on stroke prevention was still insufficient and conflicting. Our study randomly selected 14,856 patients with diabetes from the database provided by the Taiwan National Health Research Institute, and 2 cohorts were formulated according to whether metformin was in the prescription record. All cases were followed up for 4 years to track their stroke incidence. As a result, 701 (17.5%) of 3999 diabe...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Yuan-Yang Cheng, Hsin-Bang Leu, Tzeng-Ji Chen, Chen-Ling Chen, Chia-Hua Kuo, Shin-Da Lee, Chung-Lan Kao Tags: Original Articles Source Type: research
High Cholesterol Levels Are Associated with Improved Long-term Survival after Acute Ischemic Stroke
Conclusions: High admission cholesterol may be associated with increased long-term survival after IS. Future studies on the temporal profile of cholesterol levels and stroke outcome would be of interest.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Ioanna Markaki, Ulrik Nilsson, Konstantinos Kostulas, Christina Sjöstrand Tags: Original Articles Source Type: research
