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Total 3622 results found since Jan 2013.

Disruption of the Blood-Ocular Barriers in Stroke Patients (S8.008)
Conclusions:GLOS is common in stroke patients regardless of whether they receive treatment. BBB disruption appears to associate with blood-ocular barrier disruption. Whether these findings are due to the acute stroke, or merely due to a common underlying chronic process, remains to be determined.Disclosure: Dr. Hitomi has nothing to disclose. Dr. Latour has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hitomi, E., Latour, L. L., Leigh, R. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Treatment Source Type: research

Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke
Abstract18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence in patients with atherothrombotic stroke. The aim of the study was to identify plasma inflammatory biomarkers associated with plaque inflammation according to18F-FDG uptake. We conducted a prospective study of consecutive adult patients with a recent (<  7 days) anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. We included 64 patients, 57.8% of whom showed a carotid stenosis ≥ 50%. All patients under...
Source: Translational Stroke Research - March 2, 2022 Category: Neurology Source Type: research

Prehospital thrombolysis in acute stroke: Results of the PHANTOM-S pilot study
Conclusions: The data suggest that prehospital stroke care in STEMO is feasible. No safety concerns have been raised so far. This new approach using prehospital tPA may be effective in reducing call-to-needle times, but this is currently being scrutinized in a prospective controlled study.
Source: Neurology - January 7, 2013 Category: Neurology Authors: Weber, J. E., Ebinger, M., Rozanski, M., Waldschmidt, C., Wendt, M., Winter, B., Kellner, P., Baumann, A., Fiebach, J. B., Villringer, K., Kaczmarek, S., Endres, M., Audebert, H. J., for the STEMO-Consortium Tags: CT, All Cerebrovascular disease/Stroke, Critical care, Patient safety ARTICLE Source Type: research

Stroke Patients Develop Antibodies That React With Components of N-Methyl-D-Aspartate Receptor Subunit 1 in Proportion to Lesion Size Clinical Sciences
Conclusions— Antibodies that bind recombinant GluN1-S2 peptides (but not the intact GluN1 protein) develop transiently in patients after stroke in proportion to infarct size, suggesting that these antibodies are raised secondarily to neuronal damage. The anti–GluN1-S2 antibodies may provide useful information about the presence and severity of cerebral infarction. This will require confirmation in larger studies.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Kalev-Zylinska, M. L., Symes, W., Little, K. C. E., Sun, P., Wen, D., Qiao, L., Young, D., During, M. J., Barber, P. A. Tags: Ischemic biology - basic studies, Other diagnostic testing Clinical Sciences Source Type: research

Prehospital stroke care: New prospects for treatment and clinical research
Brain cells die rapidly after stroke and any effective treatment must start as early as possible. In clinical routine, the tight time–outcome relationship continues to be the major limitation of therapeutic approaches: thrombolysis rates remain low across many countries, with most patients being treated at the late end of the therapeutic window. In addition, there is no neuroprotective therapy available, but some maintain that this concept may be valid if administered very early after stroke. Recent innovations have opened new perspectives for stroke diagnosis and treatment before the patient arrives at the hospital....
Source: Neurology - July 29, 2013 Category: Neurology Authors: Audebert, H. J., Saver, J. L., Starkman, S., Lees, K. R., Endres, M. Tags: All Clinical trials, All Cerebrovascular disease/Stroke VIEWS & amp;amp; REVIEWS Source Type: research

Ct perfusion in acute ischaemic stroke: do we cover the lesion and what does it mean?
Conclusions Even with limited z–directional coverage CTP is more sensitive than NCCT ASPECTS scoring to detect evidence of acute stroke. In this cohort CTP acquisition at the basal ganglia was more often too inferior than it was too superior to maximise lesion coverage. Patients without perfusion deficits have better functional outcomes than those with perfusion deficits.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Collins, P., Dani, K., Moreton, F., McVerry, F., MacDougall, N., Macleod, M. J., Wardlaw, J., Muir, K. Tags: Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

White Matter Changes on Magnetic Resonance Imaging: A Risk Factor for Stroke in an African Population?
Background: White matter changes are frequently observed incidental findings in elderly individuals. Many studies in Europe and the United States have assessed the association of white matter changes with stroke and other diseases. No similar study has been conducted in sub-Saharan Africa, where risk factors for stroke differ. Our objective was to explore the association between severity of white matter changes (based on visual rating scales) and stroke in a Nigerian population.Methods: Magnetic resonance imaging (MRI) scans of 50 patients were retrospectively assessed and scored using 3 different visual rating scales (by ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Godwin I. Ogbole, Mayowa O. Owolabi, Bolutife P. Yusuf Tags: Original Articles Source Type: research

Establishment of an effective acute stroke telemedicine program for Australia: protocol for the Victorian Stroke Telemedicine project
RationaleUrgent treatment of acute stroke in rural Australia is problematic partly because of limited access to medical specialists. Utilization of telemedicine could improve delivery of acute stroke treatments in rural communities. AimThe study aims to demonstrate enhanced clinical decision making for use of thrombolysis within 4·5 h of ischemic stroke symptom onset in a rural setting using a telemedicine specialist support model. DesignA formative program evaluation research design was used. The Victorian Stroke Telemedicine program was developed and will be evaluated over five stages to ensure successful implementati...
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Dominique A. Cadilhac, Natasha Moloczij, Sonia Denisenko, Helen Dewey, Peter Disler, Bruce Winzar, Ian Mosley, Geoffrey A. Donnan, Christopher Bladin Tags: Protocols Source Type: research

Outcome and Risk Factors Presented in Old Patients Above 80 Years of Age Versus Younger Patients After Ischemic Stroke
Background: Older patients are associated with increased stroke prevalence, worse outcome, and risk of undertreatment in comparison with younger patients. The aim of the present study was to compare risk factor distribution and functional outcome in stroke survivors older and younger than 80 years.Methods: The analysis was based on consecutive patients admitted within 6 hours after stroke onset and discharged with ischemic stroke, surviving at least 3 months after ictus. To prevent bias, the analysis was based on a registry from before implementation of tissue plasminogen activator treatment; all patients received strok...
Source: Journal of Stroke and Cerebrovascular Diseases - May 2, 2014 Category: Neurology Authors: Line Bentsen, Louisa Christensen, Anders Christensen, Hanne Christensen Tags: Original Articles Source Type: research

Does Emergency department length of stay affect the 90-day functional outcome after acute ischemic stroke? (P3.073)
Conclusion: In our cohort, there was no association between the ED-LOS and 90-day functional outcome. Further study is ongoing to assess whether ED-LOS adversely affects outcome measures not captured by the mRS.Disclosure: Dr. Patel has nothing to disclose. Dr. Minaeian has nothing to disclose. Dr. Tunguturi has nothing to disclose. Dr. Goddeau has nothing to disclose. Dr. Henninger has received personal compensation in an editorial capacity for Stroke.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Patel, A., Minaeian, A., Tunguturi, A., Goddeau, R., Henninger, N. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Outcome Source Type: research

Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment Brief Reports
Conclusions— The prevalence of amyloid-pathology in patients with PS-MCI is not increased when compared with cognitively healthy stroke survivors and to recent estimates for cognitively healthy elderly subjects. Factors other than amyloid-pathology likely contribute to the development of PS-MCI. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01334749.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Wollenweber, F. A., Darr, S., Muller, C., Duering, M., Buerger, K., Zietemann, V., Malik, R., Brendel, M., Ertl-Wagner, B., Bartenstein, P., Rominger, A., Dichgans, M. Tags: Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET, Cerebrovascular Disease/Stroke, Cognitive Impairment Brief Reports Source Type: research

Pre-existing Small Vessel Disease in Patients with Acute Stroke from the Middle East, Southeast Asia, and Philippines
AbstractAsymptomatic small vessel disease (SVD), including white matter hyperintensities (WMHIs), periventricular hyperintensities (PVHIs), silent stroke (SS), and cerebral microbleeds (CMBs), increases the risk of stroke. There are limited studies of SVD in subjects from the Middle East and Southeast Asia (SA). All patients admitted to stroke service between 2014 and 2015 were reviewed for presence of “pre-existing” SVD. Stroke mimics with no previous history of stroke were used as controls. There were 1727 patients admitted with stroke. Analysis was done on 988 subjects (914 strokes and 74 controls) who had MRI scan ...
Source: Translational Stroke Research - November 3, 2017 Category: Neurology Source Type: research

Processes of early stroke care and hospital costs
ConclusionsEarly care in agreement with key guidelines recommendations for the management of patients with stroke may be associated with hospital savings.
Source: International Journal of Stroke - December 19, 2013 Category: Neurology Authors: Marie Louise Svendsen, Lars H. Ehlers, Heidi H. Hundborg, Annette Ingeman, Søren P. Johnsen Tags: Research Source Type: research

Significance of Periclot MMP-9 in Ischemic Stroke Patients Undergoing Intra-arterial Interventions (P4.303)
CONCLUSIONS: Decreased periclot MMP-9 may be predictive of HT after ischemic stroke, contrasting with previous work demonstrating elevated peripheral MMP-9 as predictive of HT. Increased periclot MCP-4 and angiogenin expression, as well as decreased numbers of circulating monocytes, may serve as additional predictive markers of HT. Future work should measure the activity of periclot MMP-9. Study Supported by: Shimojani, LLC and NIH (DJ).Disclosure: Dr. Song has nothing to disclose. Dr. Prager has nothing to disclose. Dr. Brennan has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Hussain has nothing to disclos...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Song, A., Prager, B., Brennan, C., Uchino, K., Hussain, M., Rasmussen, P., Janigro, D. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Interventional Treatment for Ischemic Stroke Source Type: research

The role of hippocampal pathology in post-stroke cognitive impairment
Background Cognitive impairment is common following cerebrovascular disease. Recently it has been associated with hippocampal ultra-structural damage in stroke survivors. We aim to study the long-term cognitive profile of patients after ischaemic stroke and characterise the cognitive behaviours associated with any dynamic changes in the structure, function and metabolism of the hippocampi, using multimodal MRI at 3Tesla. Methods We are conducting a dual-centre study to investigate the predictive value of diagnostic MRI and resting-state fMRI based on observing natural history of cognitive function following stroke (at bas...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Hosseini, A. A., Ispoglou, S., Hayton, T., Evans, R., Wilson, M., Sawlani, V., Rotshtein, P., Auer, D. P. Tags: Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research