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Specialty: Genetics & Stem Cells
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Total 525 results found since Jan 2013.

Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes
CONCLUSIONS: We found inflammation-related proteins that were differentially regulated in ischemic stroke cases compared with controls only in the acute phase and others that remained elevated also at later time points. This latter group of proteins could reflect underlying pathophysiological processes of relevance. Future studies both in terms of disease risk and prognostication are warranted.PMID:35686557 | DOI:10.1161/STROKEAHA.121.038349
Source: Genomics Proteomics ... - June 10, 2022 Category: Genetics & Stem Cells Authors: Tara M Stanne Annelie Angerfors Bj örn Andersson Cecilia Br ännmark Lukas Holmegaard Christina Jern Source Type: research

Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke
Conclusions: The BRAP polymorphism may not play an important role in ischemic stroke in the studied population.
Source: BMC Medical Genetics - Latest articles - January 28, 2013 Category: Genetics & Stem Cells Authors: Yi-Chu LiaoHsiu-Fen LinYuh-Cherng GuoChung-Hung ChenZhi-Zhang HuangSuh-Hang JuoRuey-Tay Lin Source Type: research

Expression profile based gene clusters for ischemic stroke detection: Whole blood gene clusters for ischemic stroke detection.
Abstract In microarray studies alterations in gene expression in circulating leukocytes have shown utility for ischemic stroke diagnosis. We studied forty candidate markers identified in three gene expression profiles to (1) quantitate individual transcript expression, (2) identify transcript clusters and (3) assess the clinical diagnostic utility of the clusters identified for ischemic stroke detection. Using high throughput next generation qPCR 16 of the 40 transcripts were significantly up-regulated in stroke patients relative to control subjects (p<0.05). Six clusters of between 5 and 7 transcripts weredisc...
Source: Genomics - August 15, 2014 Category: Genetics & Stem Cells Authors: Adamski MG, Li Y, Wagner E, Yu H, Seales-Bailey C, Soper SA, Murphy M, Baird AE Tags: Genomics Source Type: research

Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis.
CONCLUSION: Atherosclerosis may be associated with an increased risk of post-stroke dementia. Post-stroke statin use was associated with decreased risk of cognitive impairment. To confirm whether or not statins confer advantages in the post-stroke population in terms of preventing cognitive decline over and above their known effectiveness in reducing risk of further vascular events, further stroke trials including cognitive assessment and observational analyses adjusted for key confounders, focusing on key subgroups or statin use patterns are required. PMID: 31505259 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - September 6, 2019 Category: Genetics & Stem Cells Authors: Yang Z, Wang H, Edwards D, Ding C, Yan L, Brayne C, Mant J Tags: Ageing Res Rev Source Type: research

Childhood Obesity and Risk of Stroke: A Mendelian Randomisation Analysis
Conclusion: Our study provides evidence that childhood obesity is associated with a higher risk of stroke, IS, and LAS. The prevention of stroke, especially IS and LAS, should be promoted in populations with childhood obesity.
Source: Frontiers in Genetics - November 17, 2021 Category: Genetics & Stem Cells Source Type: research

Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies
Conclusion: This study highlights biologically plausible genetic determinants for incident stroke in hypertensive AAs. Ultimately, a better understanding of genetic risk factors for stroke in AAs may give new insight into stroke burden and potential clinical tools for those among the highest at risk.
Source: Frontiers in Genetics - December 21, 2021 Category: Genetics & Stem Cells Source Type: research

GSE203399 Study of the DNA methylation in the stroke outcome: an Epigenome-Wide Association Study
Contributors : Israel Fern ández-Cadenas ; Joan Montaner ; Natalia CullellSeries Type : Methylation profiling by arrayOrganism : Homo sapiensBackground and Purpose The neurological course after stroke is highly variable and is determined by demographic, clinical, and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. Methods We performed a three-stage epigenome-wide association study (EWAS) to evaluate DNA methylation associated with the difference between the National Institutes of Health Stroke Scale (NIHSS) at baseline and at disc...
Source: GEO: Gene Expression Omnibus - May 20, 2022 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research

Polymorphisms of TRIB1 Genes for Coronary Artery Disease and Stroke Risk: A Systematic Review and Meta-analysis
CONCLUSIONS: The rs2954029 A allele was significantly associated with an increased risk of CAD and stroke, according to the present meta-analysis. However, the association of rs17321515 polymorphism with susceptibility to CAD and stroke has not been found in this study.PMID:37414350 | DOI:10.1016/j.gene.2023.147613
Source: Gene - July 6, 2023 Category: Genetics & Stem Cells Authors: Jiangang Jiang Xinmin Chen Chengwei Li Xiaoma Du Huadong Zhou Source Type: research

Association of β-fibrinogen promoter gene polymorphism (−148C/T), hyperfibrinogenemia and ischemic stroke in young adult patients
Conclusion There was a significant association between SNP −148C/T and fibrinogen levels, SNP −148C/T and ischemic stroke, and fibrinogen levels and ischemic stroke.
Source: Egyptian Journal of Medical Human Genetics - December 18, 2014 Category: Genetics & Stem Cells Source Type: research

The association between three promoter polymorphisms of IL-1 and stroke: A meta-analysis.
CONCLUSION: In conclusion, our results suggested that IL-1α-889C/T polymorphism is associated with stroke risk, especially in Asians. However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis. PMID: 25917615 [PubMed - as supplied by publisher]
Source: Gene - April 23, 2015 Category: Genetics & Stem Cells Authors: Zou L, Zhao H, Gong X, Jiang A, Guan S, Wang L, Zheng S Tags: Gene Source Type: research

Chromosome 10q25 polymorphism is associated with susceptibility to large artery atherosclerotic stroke.
CONCLUSIONS: In the southeastern Chinese population, the rs11196288A > G polymorphism is associated with decreased risk of LAA stroke. PMID: 30580071 [PubMed - as supplied by publisher]
Source: Gene - December 20, 2018 Category: Genetics & Stem Cells Authors: Gu M, Wang M, Cai B, Cheng X, Li Z, Sun B, Wang F, Shi Y, Zhang Z, Liu X Tags: Gene Source Type: research

Association between K469E polymorphism of ICAM ‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis
ConclusionK469E polymorphism of ICAM ‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.
Source: Molecular Genetics & Genomic Medicine - June 2, 2019 Category: Genetics & Stem Cells Authors: Gaurav Nepal, Jayant Kumar Yadav, YuHui Kong Tags: ORIGINAL ARTICLE Source Type: research

Dual effect of methylene-tetrahydrofolate reductase and angiotensinconverting enzyme gene polymorphisms on the risk of acute ischemic stroke
J Genet. 2023;102:29.ABSTRACTIschemic stroke, a prevalent neurological disease, is the major reason of serious disability and death worldwide. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms increase homocysteine levels which also raise the risk of vascular diseases. Angiotensin-converting enzyme (ACE) gene polymorphisms can cause vascular reorganization and disrupt arterial wall stability. The aim of this study was to explore how the MTHFR and ACE gene polymorphisms are related to acute ischemic stroke. A total of 200 individuals (102 acute ischemic stroke patients and 98 healthy controls) were included in ...
Source: Journal of Genetics - May 19, 2023 Category: Genetics & Stem Cells Authors: Nevin Karakus Serbulent Yigit Nursah Basol Onur Incealtin Source Type: research