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Outcomes of Patients with Human Immunodeficiency Virus Infection Undergoing Cardiovascular Surgery in the United States
This study uses a large administrative database to show that HIV does not affect mortality, LOS, or cost, but does predispose patients to patients to increased number of blood transfusions. Rates of wound infection, pneumonia, and renal failure are similar between HIV+ and HIV- patients, while stroke is less common in the HIV+ group. Cardiovascular surgery can be performed safely for HIV+ patients.
Source: The Journal of Thoracic and Cardiovascular Surgery - August 4, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Michael P. Robich, Nicholas Schiltz, Douglas R. Johnston, Stephanie Mick, Wayne Tse, Colleen Koch, Edward G. Soltesz Source Type: research

Regular blood transfusions can stave off repeat strokes in children with sickle cell disease
(Johns Hopkins Medicine) Monthly blood transfusions can substantially reduce the risk of recurrent strokes in children with sickle cell disease who have already suffered a silent stroke, according to the results of an international study by investigators at the Johns Hopkins Children's Center, Vanderbilt University and 27 other medical institutions.
Source: EurekAlert! - Medicine and Health - August 20, 2014 Category: Global & Universal Source Type: news

Monthly blood transfusions reduce sickle cell anemia-related brain injury in children
(NIH/National Institute of Neurological Disorders and Stroke) Regular blood transfusions prevent recurrent blockage of brain blood vessels, a serious neurological side effect that occurs in one third of children with sickle cell anemia, according to a study funded by the National Institutes of Health. The findings appear in the Aug. 21 issue of the New England Journal of Medicine.
Source: EurekAlert! - Social and Behavioral Science - August 20, 2014 Category: Global & Universal Source Type: news

Blood Transfusions May Cut Risk of 'Silent' Stroke in Kids With Sickle Cell
Study found children who got monthly infusions were less likely to suffer another attack
Source: WebMD Health - August 20, 2014 Category: Consumer Health News Source Type: news

Blood Transfusions May Cut Risk of 'Silent' Stroke in Kids with Sickle Cell
Study found children who got monthly infusions were less likely to suffer another attack Source: HealthDay Related MedlinePlus Pages: Blood Transfusion and Donation, Children's Health, Sickle Cell Anemia
Source: MedlinePlus Health News - August 20, 2014 Category: Consumer Health News Source Type: news

232-i * endoaortic balloon clamping and transthoracic aortic clamping are both safe and effective in minimally invasive mitral valve surgery
Conclusion: Despite recent concerns arising about EAC, this large multicentre study shows equivalence in term of safety and effectiveness of this technique compared with TTC. Reduction in postoperative bleeding was observed in the EAC group despite the higher rate of complex redo cases.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Rinaldi, M., Krakor, R., Bentala, M., Casselman, F., Candolfi, P., Barbero, C., Goldstein, J. Tags: Adult cardiac rapid response 2 Source Type: research

Monthly blood transfusions reduce sickle cell anemia-related brain injury in children
Regular blood transfusions prevent recurrent blockage of brain blood vessels, a serious neurological side effect that occurs in one third of children with sickle cell anemia, according to a study funded by the National Institutes of Health. The findings appear in the Aug. 21 issue of the New England Journal of Medicine.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 20, 2014 Category: Neurology Source Type: news

Initial experience with routine less invasive implantation of HeartMate II left ventricular assist device without median sternotomy TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT
CONCLUSIONS Primary HMII implantation without median sternotomy is feasible and can be safely, effectively and routinely applied, using our less invasive approach. Further investigation is necessary to determine whether the non-invasive technique contributed to the low incidence of bleeding, blood transfusion, respiratory morbidity and right ventricular failure seen in this study.
Source: European Journal of Cardio-Thoracic Surgery - November 10, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Anyanwu, A. C., Itagaki, S., Pinney, S., Adams, D. H. Tags: Peripheral vascular, Aorto-iliac disease TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT Source Type: research

Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: a retrospective analysis of comparing haematological parameters and C reactive protein
Conclusions MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.
Source: BMJ Open - November 20, 2014 Category: Journals (General) Authors: Lee, J.-H., Kwon, K.-Y., Yoon, S.-Y., Kim, H.-S., Lim, C. S. Tags: Open access, Diagnostics, Haematology (incl blood transfusion) Research Source Type: research

Diabetes and hemoglobin a1c as risk factors for nosocomial infections in critically ill patients.
Conclusion. DM and HbA1c were not associated with increased VAP or BSI frequency. HbA1c was associated with repeated BSI episodes in the ICU. PMID: 24459586 [PubMed]
Source: Critical Care Research and Practice - December 1, 2014 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

Safety and efficacy of biocompatible perfusion strategy in a contemporary series of patients undergoing coronary artery bypass grafting ¿ a two-center study
Conclusions: In a contemporary cohort of patients undergoing CABG, the use of BPS is safe and effective. It is associated with excellent clinical outcomes and reduced allogeneic blood transfusions.
Source: Journal of Cardiothoracic Surgery - December 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Oz ShapiraAmit KorachFrederic PinaudAbeer DabahYusheng BaoJean CorbeauJean-Louis de BruxChristophe Baufreton Source Type: research

Blood Transfusions May Have Limited Effect on Muscle Oxygenation After Total Knee Arthroplasty
Conclusion We detected a statistically significant increase in SmO2 during the course of a single unit blood transfusion compared to baseline. However, there was no evidence of a correlation between longitudinal SmO2 and SpHb measurements.
Source: HSS Journal - March 6, 2015 Category: Orthopaedics Source Type: research

General Compared with Spinal Anesthesia for Total Hip Arthroplasty
Conclusions: General anesthesia was associated with an increased rate of adverse events and mildly increased operating room times. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: The Journal of Bone and Joint Surgery - March 18, 2015 Category: Orthopaedics Authors: Basques, B. A., Toy, J. O., Bohl, D. D., Golinvaux, N. S., Grauer, J. N. Tags: Hip Scientific Articles Source Type: research

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

Hospitalization after fainting can do more harm than good
One morning not long ago, my teenage daughter started to black out. After an ambulance ride to our local hospital’s emergency department, an electrocardiogram, and some bloodwork, she was sent home with a follow-up doctor appointment. We got the good news that Alexa is perfectly healthy, but should avoid getting too hungry or thirsty so she doesn’t faint again. And I’m feeling lucky that she didn’t need to be hospitalized, because a research letter in this week’s JAMA Internal Medicine points out that hospitalization for low-risk fainting can do more harm than good. Doctors use something called th...
Source: New Harvard Health Information - April 22, 2015 Category: Consumer Health News Authors: Heidi Godman Tags: Health fainting San Francisco Syncope Rule Source Type: news