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Total 177 results found since Jan 2013.
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders
Curr Drug Targets. 2022 Jan 17. doi: 10.2174/1389450123666220117104038. Online ahead of print.ABSTRACTNeurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any kind of structural, electrical, biochemical and functional abnormalities in neurons can lead to various types of disorders like Alzheimer's disease (AD), depression, Parkinson's disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential of complete treatment of an illness are highly desired. A range of small or...
Source: Epilepsy Curr - March 21, 2022 Category: Neurology Authors: Bhupinder Kumar Naveen Kumar Amandeep Thakur Vijay Kumar Rakesh Kumar Vinod Kumar Source Type: research
Associations of long-term exposure to fine particulate matter and its constituents with cardiovascular mortality: A prospective cohort study in China
CONCLUSIONS: This nationwide cohort study demonstrated associations of long-term exposure to PM2.5 and its constituents with increased risks of cardiovascular mortality in the general population of China. Our study highlighted the importance of PM2.5 constituents from fossil fuel combustion in the long-term cardiovascular effects of PM2.5 in China.PMID:35248978 | DOI:10.1016/j.envint.2022.107156
Source: Environment International - March 6, 2022 Category: Environmental Health Authors: Ruiming Liang Renjie Chen Peng Yin Aaron van Donkelaar Randall V Martin Richard Burnett Aaron J Cohen Michael Brauer Cong Liu Weidong Wang Jian Lei Lijun Wang Limin Wang Mei Zhang Haidong Kan Maigeng Zhou Source Type: research
New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Differential associations of particle size ranges and constituents with stroke emergency-room visits in Shanghai, China
CONCLUSION: Ultra-fine particles and some PM2.5 constituents (i.e., carbonaceous fractions, inorganic ions and some elements) may be mainly responsible for the excess risk of stroke induced by PM2.5.PMID:35104777 | DOI:10.1016/j.ecoenv.2022.113237
Source: Ecotoxicology and Environmental Safety - February 1, 2022 Category: Environmental Health Authors: Yuhao Zhang Qinglin He Yaping Zhang Xiaowei Xue Haidong Kan Xin Wang Source Type: research
Analysis of psychiatric consultations in the department of neurology and stroke unit: diagnosis and therapy
CONCLUSIONS: Patients in the department of neurology and stroke unit underwent a psychiatric consultation most frequently. Optimizing the care of aneurological patient is related to close cooperation of a neurologist and a psychiatrist, as well as developing and updating common positions for the management of selected disease entities.PMID:34997738 | DOI:10.12740/PP/OnlineFirst/116320
Source: Psychiatria Polska - January 8, 2022 Category: Psychiatry Authors: Tomasz Chmiela Pawe ł Piekarz Beata Łabuz-Roszak Anna Warchala Ewa Krzystanek Agnieszka Gorzkowska Source Type: research
