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Pharmacotherapy for SARS-CoV-2 and Seizures for drug repurposing presumed on Mechanistic Targets
CONCLUSION: These findings would hopefully provide the basis for initiating further studies on the pathogenesis and drug targeting strategies for this emerging infection accompanied with seizures or in people with epilepsy.PMID:34645381 | DOI:10.2174/1874467214666211013122528
Source: Epilepsy Curr - October 14, 2021 Category: Neurology Authors: Divya Goel Ankit Srivastava Ángel Aledo-Serrano Anuja Krishnan Divya Vohora Source Type: research

Acute Neurologic Manifestations of Respiratory Viruses
This article describes the most common respiratory viruses that have neurologic manifestations, with a focus on SARS-CoV-2 and COVID-19. RECENT FINDINGS In vitro and in vivo studies have better elucidated the neurotropism of various respiratory viruses. Understanding host cell receptors that mediate viral binding and entry not only demonstrates how viruses enter host cells but also provides possible mechanisms for therapeutic interventions. Elucidation of SARS-CoV-2 binding and fusion with host cells expressing the angiotensin-converting enzyme 2 (ACE2) receptor may also provide greater insights into its systemic an...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Changes in Stroke Patients ’ Health-Seeking Behavior by COVID-19 Epidemic Regions: Data from the Korean Stroke Registry
Conclusion: Korean stroke patients in a CO ­VID-19 epidemic region exhibited distinct changes in health-seeking behaviors. Appropriate triage system and public education regarding the importance of early treatment are needed during the COVID-19 pandemic.Cerebrovasc Dis
Source: Cerebrovascular Diseases - September 30, 2021 Category: Neurology Source Type: research

Association of COVID-19 Infection and Juvenile Stroke: a Case Series
The objective of this study is to discuss association of juvenile stroke with COVID-19 infection. We analyzed 5 COVID-19 positive and stroke patients with a mean age of 41.2 years-old. Three patients developed large vessel occlusion, one small vessel occlusion and one PRES with superimposed lobar ICH, respectively. The mean initial NIHSS of our patients was 11.6. Except the one with massive cerebellar infarct, a desirable outcome occurred with a mean mRS 2.6 at discharge. The mean ESR and CRP level was elevated to 30.4 ml and 32 mg/dl. The severity of COVID-19 infection was considered mainly as mild. COVID-19 infection has...
Source: Acta Neurologica Taiwanica - September 22, 2021 Category: Neurology Authors: Hossein Mozhdehipanah Sepideh Paybast Shirin Mavandadi Source Type: research

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