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Of mice and men – modeling post‐stroke depression experimentally
Summary At least one third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant, because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modeled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammati...
Source: British Journal of Pharmacology - May 19, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: Review Article – Animal Models in Psychiatry Research Themed Issue Source Type: research

Of mice and men: modelling post‐stroke depression experimentally
At least one‐third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modelled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammation, an...
Source: British Journal of Pharmacology - July 2, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: REVIEW Source Type: research

Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling.
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu, Jianxin Chen, Ruocong Yang, Feipeng Duan, Shaojing Li, Xiuping Chen Tags: RESEARCH PAPER Source Type: research

A novel snake‐venom derived GPIb antagonist, anfibatide, protects mice from acute experimental ischemic stroke and reperfusion injury
CONCLUSIONS AND IMPLICATIONSOur data indicate anfibatide is a safe GPIb antagonist which exerts protective effect on cerebral ischemia and reperfusion injury. Anfibatide, as a promising candidate, could be beneficial for the treatment of ischemic stroke.
Source: British Journal of Pharmacology - April 27, 2015 Category: Drugs & Pharmacology Authors: Ting‐Ting Li, Man‐Li Fan, Shi‐Xiang Hou, Xiao‐Yi Li, Devin M Barry, Hui Jin, Sheng‐Yong Luo, Feng Kong, Lie‐Kui Liu, Xiang‐Rong Dai, Guo‐Hui Zhang, Lan‐Lan Zhou Tags: Research Paper Source Type: research

Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Drp‐1, a potential therapeutic target for brain ischaemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 increases the resistance of neurons of hippocampal CA3 affected by global ischaemia and contributes to the tolerance conferred by IPC highlight Drp‐1 as a potential therapeutic target for brain ischaemic stroke.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post ‐ischemic neuroregeneration and recovery of neurological functions in rats
Conclusion and ImplicationsTBN's ability to simultaneously provide neuroprotection and pro‐neurogenic effect may be a promising treatment for both acute phase neuroprotection and long‐term functional recovery after ischemic stroke.
Source: British Journal of Pharmacology - November 21, 2017 Category: Drugs & Pharmacology Authors: Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo ‐yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang Tags: RESEARCH PAPER Source Type: research

Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygen‐glucose deprivation via PPARγ and 5‐HT1A
CONCLUSIONS AND IMPLICATIONSThese data suggest that activity at the BBB could represent an as yet unrecognised mechanism of CBD‐induced neuroprotection in ischaemic stroke, mediated by PPARγ and 5‐HT1A. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 1, 2015 Category: Drugs & Pharmacology Authors: William H Hind, Timothy J England, Saoirse E O'Sullivan Tags: RESEARCH PAPER Source Type: research

Cannabidiol protects an in vitro model of the blood–brain barrier from oxygen‐glucose deprivation via PPARγ and 5‐HT1A receptors
Conclusions and ImplicationsThese data suggest that preventing permeability changes at the BBB could represent an as yet unrecognized mechanism of CBD‐induced neuroprotection in ischaemic stroke, a mechanism mediated by activation of PPARγ and 5‐HT1A receptors.
Source: British Journal of Pharmacology - February 3, 2016 Category: Drugs & Pharmacology Authors: William H Hind, Timothy J England, Saoirse E O'Sullivan Tags: RESEARCH PAPER Source Type: research

Bisperoxovandium (pyridin ‐2‐squaramide) Targets Both PTEN and Erk1/2 to Confer Neuroprotection
Conclusions and ImplicationsbpV(pis) confers neuroprotection in OGD‐induced injury in vitro and in cerebral ischemia in vivo through suppressing PTEN and activating Erk1/2, respectively. Thus, bpV(pis) is a bi‐target neuroprotectant that may be developed as a drug candidate for stroke treatment.
Source: British Journal of Pharmacology - January 26, 2017 Category: Drugs & Pharmacology Authors: Zhi ‐Feng Zhang, Juan Chen, Xin Han, Ya Zhang, Hua‐Bao Liao, Rui‐Xue Lei, Yang Zhuang, Ze‐Fen Wang, Zhiqiang Li, Jin‐Cao Chen, Wei‐Jing Liao, Hai‐Bing Zhou, Fang Liu, Qi Wan Tags: RESEARCH PAPER Source Type: research

VIP and PACAP: Neuropeptide modulators of CNS inflammation, injury, and repair
Summary page Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis (ALS) and aging‐related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Endogenous defense mechanisms against these pathologies include those that are directly neuroprotective, and those that modulate the expression of inflammatory mediators in microglia, astrocytes, and invading inflammatory cells. While a number of mechanisms and molecules have been identified that can directly promote neuronal survival, less is known about how the brain...
Source: British Journal of Pharmacology - March 20, 2013 Category: Drugs & Pharmacology Authors: J A Waschek Tags: Review Article Source Type: research

Effects of the Antianginal Drug, Ranolazine, on the Brain Sodium Channel NaV1.2 and Its Modulation By Extracellular Protons
Conclusions and ImplicationsOur work provides novel insights into the modulation of brain sodium channel, NaV1.2, by ranolazine. We demonstrate that ranolazine binds NaV1.2 in a state‐dependent manner, and that the effects of ranolazine are slowed but not abolished by protons. Our results suggest that further research performed on channels with epilepsy‐causing mutations may prove ranolazine to be an efficacious therapy.
Source: British Journal of Pharmacology - March 8, 2013 Category: Drugs & Pharmacology Authors: C H Peters, S Sokolov, S Rajamani, P C Ruben Tags: Research Paper Source Type: research

The TRPM4 channel inhibitor 9‐phenanthrol
Abstract The phenanthrene‐derivative 9‐phenanthrol is a recently identified inhibitor of the TRPM4 Ca2+‐activated non‐selective cation channel whose mechanism of action remains to be determined. Subsequent studies performed on other ion channels confirm the specificity of the drug for TRPM4. In addition, 9‐phenanthrol modulates a variety of physiological processes through TRPM4 current inhibition and thus exerts beneficial effects in several pathological conditions. 9‐phenanthrol modulates smooth muscle contraction in bladder and cerebral arteries, impacts spontaneous activity in neurons and heart, and reduces ...
Source: British Journal of Pharmacology - January 16, 2014 Category: Drugs & Pharmacology Authors: R Guinamard, T Hof, C A Del Negro Tags: Review Article Source Type: research

Angiotensin‐(1‐7) Induces Cerebral Ischemic Tolerance by Promoting Brain Angiogenesis in a Mas/eNOS‐Dependent Pathway
Conclusions and implicationsOur results provide the first evidence that Ang‐(1‐7) promotes brain angiogenesis via a Mas/eNOS‐dependent pathway, which enhances tolerance against subsequent cerebral ischemia. These findings highlight brain Ang‐(1‐7)/Mas signaling as a potential target in stroke prevention.
Source: British Journal of Pharmacology - May 13, 2014 Category: Drugs & Pharmacology Authors: Teng Jiang, Jin‐Tai Yu, Xi‐Chen Zhu, Qiao‐Quan Zhang, Meng‐Shan Tan, Lei Cao, Hui‐Fu Wang, Jie Lu, Qing Gao, Ying‐Dong Zhang, Lan Tan Tags: Research Paper Source Type: research

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